Results 251 to 260 of about 314,387 (344)

HIV drug resistance in sub-Saharan Africa: public health questions and the potential role of real-world data and mathematical modelling

, 2018
Reneé de Waal, Richard Lessells, Anthony Hauser, Roger D. Kouyos, Mary‐Ann Davies, Matthias Egger, Gilles Wandeler   +6 more
openalex   +1 more source

The Role of SAMHD1 in Viral Resistance and Transduction Efficiency Challenges in Pediatric Hematological Malignancies: Mechanistic Insights and Clinical Perspectives

European Journal of Haematology, EarlyView.
SAMHD1 regulates intracellular dNTP pools, influencing lentiviral transduction, gene therapy efficiency, and disease progression in pediatric hematological malignancies. Integrated bioinformatics and targeted strategies, including CRISPR and pharmacological inhibition, highlight its therapeutic potential.
Waseem Alzamzami
wiley   +1 more source

Epidemiological dynamics and molecular characterization of HIV drug resistance in eastern China from 2020 to 2023. [PDF]

Front Microbiol
Zhu M, Sun Z, Zhang X, Luo W, Wu S, Ye L, Xu K, Chen J.   +7 more
europepmc   +1 more source

Frontline Therapy in Diffuse Large B‐Cell Lymphoma: Evolving Standards, Biological Insights, and Future Directions

European Journal of Haematology, EarlyView.
ABSTRACT Diffuse large B‐cell lymphoma (DLBCL) remains the most common aggressive lymphoma, representing a biologically heterogeneous disease with diverse clinical behaviors. For more than two decades, R‐CHOP has been the cornerstone of frontline treatment, curing approximately two‐thirds of patients.
Mamdouh Skafi, Santino Caserta, Ernesto Vigna, Antonella Bruzzese, Nicola Amodio, Eugenio Lucia, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Maria Eugenia Alvaro, Fortunato Morabito, Enrica Antonia Martino, Massimo Gentile   +12 more
wiley   +1 more source

Cost-effectiveness of pretreatment HIV drug resistance testing in people living with HIV in Iran. [PDF]

PLoS One
Mirzaei H, Iranpour A, Esmaeilzadeh F, Barouni M, Mehrabi F, Ranjbar E, Sharifi H.   +6 more
europepmc   +1 more source

A global perspective on transitioning from pediatric to adult care in epilepsy

Epilepsia, EarlyView.
Abstract Objective Transition planning in epilepsy is crucial to ensure continuity of care, particularly for adolescents with complex needs, yet global practices remain undefined. The International League Against Epilepsy Transition Task Force (ILAE TTF) aimed to evaluate worldwide practices, barriers, and provider perspectives on transitioning ...
Danielle M. Andrade, Nathalie Jetté, Ilakkiah Chandran, Puja Patel, Guido Rubboli, J. Helen Cross, Dana Craiu, Chong Tin Tan, Edward Kija, Eva Fung, Tiziana Granata, Hassan Hosny, Marco Mula, Kate Riney, Renée A. Shellhaas, Maria Siddiqui, Quratulain Zulfiqar Ali, Julien Hébert, Paula Marques, Bronte Kerrigan, Caihong Ji, Kette Valente, Jaime Carrizosa, Rima Nabbout   +23 more
wiley   +1 more source

HIV-DRIVES: HIV drug resistance identification, variant evaluation, and surveillance pipeline. [PDF]

Access Microbiol
Kanyerezi S, Sserwadda I, Ssemaganda A, Seruyange J, Ayitewala A, Oundo HR, Tenywa W, Kagurusi BA, Tusabe G, Were S, Ssewanyana I, Nabadda S, Namaganda MM, Mboowa G.   +13 more
europepmc   +1 more source

Lung organoids as a human system for Mycobacteria infection modeling and drug testing

The FEBS Journal, EarlyView.
Mycobacterial infections, including tuberculosis (TB) and infections by nontuberculous mycobacteria (NTM), are still public health issues. In 2023, TB caused 1.25 million deaths, while NTM remain a clinical challenge for patients with cystic fibrosis (CF).
Stephen Adonai Leon‐Icaza, Romain Vergé, Raoul Mazars, Laurence Berry, Céline Cougoule   +4 more
wiley   +1 more source

Full-Spectrum Surveillance of Pre-Treatment HIV Drug Resistance in Southeastern China. [PDF]

Pharmaceuticals (Basel)
Zhang J, Sun B, Sheng Z, Ding X, Fan Q, Huang G, Guo Z, Zhong P, Liao L, Xing H, Xia Y, Chai C, Jiang J.   +12 more
europepmc   +1 more source

Leishmania donovani's protein tyrosine phosphatases interact with DUF21 and respond to environmental magnesium

The FEBS Journal, EarlyView.
The Leishmania phosphatase PTP1, and possibly the genetically similar PTP2, interacts with the Leishmania transmembrane protein DUF21. When both ptp1 and ptp2 are knocked out of Leishmania (LdΔPTP1/2), the parasite can no longer survive without magnesium in vitro and has reduced viability in the host macrophage. Conversely, in duf21 knockout (LdΔDUF21),
Kayla Paulini, Hira Khursheed, Wen Wei Zhang, Isabelle Aubry, Greg Matlashewski, Michel L. Tremblay, Patrick Lypaczewski   +6 more
wiley   +1 more source