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Reversibility of HIV Drug Resistance
Science, 2000Using a mathematical model, Blower et al . ([1][1]) predicted the impact of antiretroviral therapy (ART) on future trends in the sexual spread of human immunodeficiency virus (HIV). The model employed Latin hypercube sampling to allow for the high degree of uncertainty in the estimation of ...
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Structural Mechanisms of HIV Drug Resistance
Annual Review of Pharmacology and Toxicology, 1996Antiviral therapy for AIDS has focused on the discovery and design of inhibitors for two main enzyme targets of the human immunodeficiency virus type 1 (HIV)--reverse transcriptase (RT) and protease (PR). Despite several classes of promising new anti-HIV agents, the clinical emergence of drug-resistant variants of HIV has severely limited the long-term
J W, Erickson, S K, Burt
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Transmission of HIV-1 drug resistance
Journal of Clinical Virology, 2004The use of highly-active anti-retroviral therapy (HAART) for treating HIV infections is increasing. Recent studies have demonstrated that HAART is improving both the length and quality of life in HIV-infected patients. Resistant strains of HIV arise when drug adherence is poor.
Julian W, Tang, Deenan, Pillay
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Understanding HIV-1 Drug Resistance
Therapeutic Drug Monitoring, 2004Infection with drug-resistant HIV-1 may result from the acquisition of mutant strains or from their selection within the individual; either can compromise the efficacy of antiretroviral therapy (ART). Drug-resistance testing is recommended to assist in the choice of ART.
Lisa M, Frenkel, Nicole H, Tobin
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2010
HIV genotypic resistance testing has become a routine test informing the management of HIV-positive patients. This chapter describes the background of this testing and provides a protocol for undertaking the assay by a home-brew method. Methods for interpretation of the data are also outlined.
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HIV genotypic resistance testing has become a routine test informing the management of HIV-positive patients. This chapter describes the background of this testing and provides a protocol for undertaking the assay by a home-brew method. Methods for interpretation of the data are also outlined.
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La Revue du praticien, 2006
HIV drug resistance can be defined as any change (in protease, reverse transcriptase gene or envelope protein) that improves viral replication in the presence of an inhibitor. One of the most important causes of treatment failure is the development of resistance to antiretrovirals by HIV.
Anne-Geneviève, Marcelin +1 more
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HIV drug resistance can be defined as any change (in protease, reverse transcriptase gene or envelope protein) that improves viral replication in the presence of an inhibitor. One of the most important causes of treatment failure is the development of resistance to antiretrovirals by HIV.
Anne-Geneviève, Marcelin +1 more
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Surveillance of HIV and tuberculosis drug resistance
The Lancet, 2005Knowing the proportion of tuberculosis patients living with HIV is useful for health planning and for epidemiological tracking of HIV. Theoretically this statistic can be obtained without much effort because diagnostic HIV testing is part of the routine medical management of tuberculosis.
Josef, Decosas, Francois, Boillot
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HIV-1 chemotherapy and drug resistance
Clinical and Diagnostic Virology, 1995Therapy with inhibitors of human immunodeficiency virus type 1 (HIV-1) replication has had only transient clinical benefit to date. It has been speculated that drug-resistant virus mutants may contribute to therapeutic failure.To extrapolate from the biology of drug-resistant HIV-1 to improve antiretroviral chemotherapeutic strategies.The literature ...
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Global HIV drug resistance surveillance
Scandinavian Journal of Infectious Diseases, 2003The transmission of drug-resistant strains of human immunodeficiency virus (HIV) is of increasing concern in countries where antiretroviral therapy is widely used and does not spare countries where highly effective antiretroviral therapy has been recently introduced.
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HIV drug resistance and viral fitness
2000Publisher Summary The first documented cases of HIV drug resistance concerned AZT (zidovudine), a nucleoside analog that inhibits HIV replication by virtue of its activity, as a DNA chain terminator. Several mutations in the viral reverse transcriptase (RT), the enzyme that transcribes virion RNA into DNA in the newly infected cell, were identified ...
F, Clavel, E, Race, F, Mammano
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