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Optimising HIV drug resistance testing laboratory networks in Kenya: insights from systems engineering modelling. [PDF]
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2023
Abstract According to the Centers for Disease Control and Prevention (2022), approximately 35% of persons with diagnosed HIV infection in the United States do not have a suppressed viral load, underscoring ongoing gaps in HIV care—many of which were exacerbated with the COVID-19 pandemic.
Carolyn Chu +2 more
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Abstract According to the Centers for Disease Control and Prevention (2022), approximately 35% of persons with diagnosed HIV infection in the United States do not have a suppressed viral load, underscoring ongoing gaps in HIV care—many of which were exacerbated with the COVID-19 pandemic.
Carolyn Chu +2 more
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Annual Review of Pharmacology and Toxicology, 1992
Infection with human immunodeficiency virus (HIV) is a chronic process with persistent, high rates of replication. The virus exhibits high rates of mutation over time within the same individual. It is thus not surprising that drug-resis tant mutants of HIV emerge under the selective pressure of prolonged chemotherapy, especially with the knowledge of ...
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Infection with human immunodeficiency virus (HIV) is a chronic process with persistent, high rates of replication. The virus exhibits high rates of mutation over time within the same individual. It is thus not surprising that drug-resis tant mutants of HIV emerge under the selective pressure of prolonged chemotherapy, especially with the knowledge of ...
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Selection of drug-resistant HIV
Trends in Microbiology, 1999Resistance to antiretroviral drugs by HIV develops from competition among several different virus variants within an individual. Recent studies have measured the changing proportions of HIV populations, which differ by single nucleic acids, under the selective pressures exerted by the addition or removal of antiretroviral drugs.
P R, Harrigan, C S, Alexander
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Understanding HIV-1 Drug Resistance
Therapeutic Drug Monitoring, 2004Infection with drug-resistant HIV-1 may result from the acquisition of mutant strains or from their selection within the individual; either can compromise the efficacy of antiretroviral therapy (ART). Drug-resistance testing is recommended to assist in the choice of ART.
Lisa M, Frenkel, Nicole H, Tobin
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Testing for HIV-1 drug resistance
Molecular Diagnosis, 2001Viral resistance to antiretroviral agents may limit the efficacy of current treatment regimens for HIV-1 infection. The mutational patterns underlying resistance to each antiretroviral agent are often quite diverse, and cross-resistance patterns in each of the currently available classes are complex.
G J, Hanna, A M, Caliendo
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2010
HIV genotypic resistance testing has become a routine test informing the management of HIV-positive patients. This chapter describes the background of this testing and provides a protocol for undertaking the assay by a home-brew method. Methods for interpretation of the data are also outlined.
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HIV genotypic resistance testing has become a routine test informing the management of HIV-positive patients. This chapter describes the background of this testing and provides a protocol for undertaking the assay by a home-brew method. Methods for interpretation of the data are also outlined.
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Adherence and HIV Drug Resistance
HIV Clinical Trials, 2004(2004). Adherence and HIV Drug Resistance. HIV Clinical Trials: Vol. 5, No. 2, pp. 112-115.
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Global HIV drug resistance surveillance
Scandinavian Journal of Infectious Diseases, 2003The transmission of drug-resistant strains of human immunodeficiency virus (HIV) is of increasing concern in countries where antiretroviral therapy is widely used and does not spare countries where highly effective antiretroviral therapy has been recently introduced.
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