Results 131 to 140 of about 4,520,848 (313)

The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome

Biological Reviews, EarlyView.
ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke, Søren B. Hansen, Morten T. Limborg   +2 more
wiley   +1 more source

Spread of HIV-DNA in CD4+ T-cells subsets depends on ART initiation timing

Journal of Virus Eradication, 2017
P. Gantner, C. Barnig, M. Partisani Marialuisa, G. Beck-Wirth, J.-P. Faller, M. Martinot, M. Mosheni-Zadeh, C. Cheneau, M.-L. Batard, P. Fischer, B. Uring-Lambert, S. Bahram, D. Rey, S. Fafi-Kremer   +13 more
doaj   +1 more source

Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand.

New England Journal of Medicine, 2009
S. Rerks-Ngarm, P. Pitisuttithum, S. Nitayaphan, J. Kaewkungwal, J. Chiu, R. Paris, Nakorn Premsri, C. Namwat, M. de Souza, Elizabeth Adams, M. Benenson, S. Gurunathan, Jim Tartaglia, J. McNeil, D. Francis, D. Stablein, D. Birx, S. Chunsuttiwat, C. Khamboonruang, P. Thongcharoen, M. Robb, Nelson L. Michael, P. Kunasol, Jerome H. Kim   +23 more
semanticscholar   +1 more source

Synthetic Cathepsin B Sensitive Adjuvant‐Peptide Conjugates to Target Intracellular Toll‐Like Receptors 7 and 8

ChemistryEurope, EarlyView.
Cathepsin B‐sensitive peptide–adjuvant conjugates are designed, synthesized, and evaluated to deliver an antigenic peptid and an adjuvant targeting Toll‐like receptors 7 and 8 (TLR7/8) to antigen presenting cells. The adjuvant is released by cathepsin B resulting in antigen presentation and TLR mediated T cell activation.
Marjolein M. E. Isendoorn, Giulia Castello, Nico J. Meeuwenoord, Martijn Verdoes, Jeroen D. C. Codée, Ferry Ossendorp, Dmitri V. Filippov   +6 more
wiley   +1 more source

Recent Advances in Chemical Probing Strategies for RNA Structure Determination in Vivo

Chemistry – A European Journal, EarlyView.
This Review illustrates how structural probes combined with advanced sequencing technologies are revolutionizing our ability to map RNA structures and interactions within living cells. It highlights the development of innovative strategies tailored to probe RNA structures in particular biological contexts.
Maryana Yarshova, Jieyu Zhao, Chun Kit Kwok   +2 more
wiley   +1 more source

CLINICAL FEATURES CYTOMEGALOVIRUS INFECTION IN PREGNANT HIV-INFECTED WOMEN

Кубанский научный медицинский вестник, 2016
Conducted comprehensive monitoring of pregnancy in 254 HIV-infected women of Krasnodar region with an average age at the time of taking the registration of pregnancy - 26,9 ± 0,3 years and gestational age 19,2 ± 0,5 weeks.
Y. G. Shakhverdyan
doaj  

Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection.

Cell, 1996
Rong Liu, W. Paxton, Sunny S. Choe, Daniel Ceradini, S. R. Martin, R. Horuk, M. MacDonald, H. Stuhlmann, R. Koup, N. Landau   +9 more
semanticscholar   +1 more source

Maternal‐to‐Infant Transfer of Medications for Type 2 Diabetes Mellitus Via Breastmilk: A Systematic Review of Available Evidence and Clinical Guidelines

Clinical Pharmacology &Therapeutics, EarlyView.
This review evaluates the available pharmacokinetic data on the plasma‐to‐breastmilk transfer of first‐ and second‐line T2DM drugs against available clinical guideline recommendations. A list of drug therapies for treating T2DM was generated from national and international clinical guidelines.
Katherine Richardson, Joshua Kiptoo, Beatrice Mpora Odongkara, Francis Williams Ojara, Catriona Waitt   +4 more
wiley   +1 more source

Advancing Maternal Health with Long‐Acting Therapeutics: Priorities, Efficacy and Safety Considerations, and Emerging Technologies

Clinical Pharmacology &Therapeutics, EarlyView.
Maternal health remains a critical global concern, particularly in underserved populations and in low‐ and middle‐income countries where access to safe and effective therapeutics is limited. Despite the use of medications by most women during pregnancy, the exclusion of pregnant and lactating women from clinical trials has resulted in significant data ...
Rachel K. Scott, Sharon Nachman, Ethel D. Weld, Rachel Daley, Shakir Atoyebi, Robert Bies, Catriona Waitt, Adeniyi Olagunju   +7 more
wiley   +1 more source

HIV infection and coronary heart disease: mechanisms and management

Nature Reviews Cardiology, 2019
P. Hsue, D. Waters
semanticscholar   +1 more source