Results 71 to 80 of about 2,617,462 (305)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Implementation of tuberculosis intensive case finding, isoniazid preventive therapy, and infection control ("Three I's") and HIV-tuberculosis service integration in lower income countries [PDF]

, 2016
World Health Organization advocates for integration of HIV-tuberculosis (TB) services and recommends intensive case finding (ICF), isoniazid preventive therapy (IPT), and infection control ("Three I's") for TB prevention and control among persons living ...
M Katherine Charles, Barbara Castelnuovo (10700), Nguyen Thi Dung, Divine Avit-Edi, Cortés Moncada, Claudia, IeDEA, Ballif, Marie, Nakigozi, Gertrude, Marie Ballif, Durier, Nicolas, Dusingize, Jean Claude, Charles, M Katherine, Nguyen, Thi Dung, Wester, C William, ,, Meridith Blevins, Dung, Nguyen Thi, Cortes, Claudia P, Cortes, Claudia P., Fenner, Lukas, C William Wester, Wester, C. William, Jean Claude Dusingize (473718), Divine Avit-Edi (2609464), Claudia P. Cortes (473719), Mary Lou Lindegren (2609461), Lindegren, Mary Lou, Gertrude Nakigozi, Charles, M. Katherine, Gertrude Nakigozi (247948), C. William Wester (250717), Timothy R. Sterling (148936), Lukas Fenner, Marie Ballif (368655), Blevins, Meridith, Nicolas Durier (326615), Jean Claude Dusingize, Claudia P Cortes, Avit-Edi, Divine, Sterling, Timothy R., Nguyen Thi Dung (245054), Nicolas Durier, Castelnuovo, Barbara, Timothy R Sterling, International epidemiology Databases to Evaluate AIDS (IeDEA) Collaboration, Mary Lou Lindegren, Barbara Castelnuovo, Lukas Fenner (149822), Sterling, Timothy R, Meridith Blevins (291088), M. Katherine Charles (2609458), Sterling TR, Ballif M, Castelnuovo B, Fenner L, Blevins M, Charles MK, Avit-Edi D, Durier N, Cortes CP, Nakigozi G, Wester CW, Lindegren ML, Dung NT, Dusingize JC   +64 more
core   +3 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

The Human Penis Is a Genuine Immunological Effector Site

Frontiers in Immunology, 2017
The human penis is a main portal of entry for numerous pathogens, and vaccines able to control resulting infections locally are highly desirable. However, in contrast to the gastrointestinal or vaginal mucosa, the penile immune system and mechanisms ...
Alexis Sennepin, Alexis Sennepin, Alexis Sennepin, Fernando Real, Fernando Real, Fernando Real, Marine Duvivier, Marine Duvivier, Marine Duvivier, Yonatan Ganor, Yonatan Ganor, Yonatan Ganor, Sonia Henry, Sonia Henry, Sonia Henry, Diane Damotte, Marc Revol, Sonia Cristofari, Morgane Bomsel, Morgane Bomsel, Morgane Bomsel   +20 more
doaj   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Is the HCV-HIV co-infection prevalence amongst injecting drug users a marker for the level of sexual and injection related HIV transmission?

, 2013
BACKGROUND: Amongst injecting drug users (IDUs), HIV is transmitted sexually and parenterally, but HCV is transmitted primarily parenterally. We assess and model the antibody prevalence of HCV amongst HIV-infected IDUs (denoted as HCV-HIV co-infection ...
?, ?, Martin, Natasha K, Strathdee, Steffanie, Beattie, Tara, Vickerman, Peter, EMCDDA Collaborative Group, Jarlais, Don Des, Wiessing, Lucas, Roy, Anuradha, Hickman, Matthew   +9 more
core   +1 more source

Candidate polyanion microbicides inhibit HIV-1 infection and dissemination pathways in human cervical explants. [PDF]

, 2006
BACKGROUND: Heterosexual intercourse remains the major route of HIV-1 transmission worldwide, with almost 5 million new infections occurring each year.
Wallace, GS, Mesquita Pedro MM, Fletcher, PS, Fletcher Patricia S, Patricia S Fletcher, Wallace Gregory S, Mesquita, PM, Pedro MM Mesquita, Robin J Shattock, Shattock Robin J, Gregory S Wallace, Shattock, RJ   +11 more
core   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

The epidemiology of gonorrhoea, chlamydial infection and syphilis in four African cities.

, 2001
OBJECTIVES: To compare the epidemiology of gonorrhoea, chlamydial infection and syphilis in four cities in sub-Saharan Africa; two with a high prevalence of HIV infection (Kisumu, Kenya and Ndola, Zambia), and two with a relatively low HIV prevalence ...
Laga, M., Morison, L., Robinson, NJ, Weiss, HA, Anagonou, S, Hayes, R. J., Kahindo, M., Buvé, A, Van Dyck, E, Musonda, R, Van Dyck, E., Zekeng, L, Buvé, A., Zekeng, L., Weiss, H. A., Musonda, R., Study Group on Heterogeneity of HIV Epidemics in African Cities, Kahindo, M, Morison, L, Anagonou, S., Laga, M, Robinson, N. J., Hayes, RJ   +22 more
core   +1 more source