Results 161 to 170 of about 1,751,474 (312)

Do drugs approved via expedited approval pathways have therapeutic advantages? A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Regulators use expedited approval pathways to speed market approval and patient access to promising new drugs. However, there is uncertainty about whether these pathways are successful in approving drugs with significant therapeutic advantages. This systematic review aims to examine the safety, effectiveness and cost‐effectiveness of drugs approved via
Ashleigh Hooimeyer, Eliza J. McEwin, Zhicheng Wang, Joel Lexchin, Barbara Mintzes   +4 more
wiley   +1 more source

Cost-Effectiveness of Reducing HIV Infections Through Screening and Treating Alcohol Use and Depression in KwaZulu-Natal, South Africa: A Mathematical Modeling Study. [PDF]

J Acquir Immune Defic Syndr
Jeetoo M, Yeo YR, Charles DL, Moll AP, Shenoi SV, Morojele NK, Mbaya JK, Zama P, Gasa S, Francis JM, Braithwaite RS.   +10 more
europepmc   +1 more source

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source

HIV and and transgender people

HIV Diagnoses in the US, 2009-20142,351 TRANSGENDER PEOPLE RECEIVED AN HIV DIAGNOSIS. OF THESE:\u2022 84% WERE TRANSGENDER WOMEN\u2022 15% WERE TRANSGENDER MEN*\u2022 ABOUT HALF LIVED IN THE SOUTHcdc-hiv-transgender-factsheet ...

core   +1 more source

Bloodborne HIV infections in sub-Saharan Africa: evidence of clusters and response options. [PDF]

Front Public Health
Gisselquist D.
europepmc   +1 more source

National HIV Prevention progress report, 2015 [PDF]

Reaching our nation\ue2\u20ac\u2122s HIV prevention goals is essential for protecting and improving the health of all people who are at risk for or living with HIV infection.

core  

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Regulatory harmonization: Evolution, globalization and future directions

British Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm, Elaine Y. L. Blair, Christine Y. Lu   +2 more
wiley   +1 more source

Rising HIV infections and shifting transmission patterns in Bangladesh: Emerging risks among key populations. [PDF]

Prev Med Rep
Hawk A, Akter M, Adebayo UO, Jamil S.
europepmc   +1 more source

Pharmacogenomics of dolutegravir: A scoping review of evidence, gaps and clinical implications

British Journal of Clinical Pharmacology, EarlyView.
Dolutegravir underpins modern first‐ and second‐line HIV treatment regimens; however, interindividual variability in its disposition and tolerability presents challenges for optimal use. This scoping review mapped current evidence on the pharmacogenomics of dolutegravir, focusing on pharmacokinetics and pharmacodynamics, and methodological limitations ...
Ronald Kiguba, Mishael Ssesanga, Munir Pirmohamed   +2 more
wiley   +1 more source