Results 161 to 170 of about 476,743 (314)

A descriptive case series of hepatotoxicity associated with CFTR modulators and possible relevance of pharmacogenetic polymorphisms in cystic fibrosis patients

British Journal of Clinical Pharmacology, EarlyView.
Cystic fibrosis transmembrane conductance regulator (CFTR) modulators are widely used in patients with cystic fibrosis and significantly improve respiratory function and quality of life. However, their effectiveness may be limited by liver damage, which sometimes leads to treatment discontinuation, and the mechanisms underlying this remain poorly ...
Clara Laffitte Redondo, Venceslas Bourdin, Abd El Kader Ait Tayeb, Sihem Benaboud, Inès Martins, Caroline Joyau, Myriam Benhamida, Isabelle Sermet‐Gaudelus, Clémence Martin, Pierre Régis Burgel, Céline Verstuyft, Laurent Chouchana, Estelle Ayme‐Dietrich   +12 more
wiley   +1 more source

HIV and and transgender people

HIV Diagnoses in the US, 2009-20142,351 TRANSGENDER PEOPLE RECEIVED AN HIV DIAGNOSIS. OF THESE:\u2022 84% WERE TRANSGENDER WOMEN\u2022 15% WERE TRANSGENDER MEN\u2022 ABOUT HALF LIVED IN THE SOUTHcdc-hiv-transgender-factsheet ...

core   +1 more source

Bloodborne HIV infections in sub-Saharan Africa: evidence of clusters and response options. [PDF]

Front Public Health
Gisselquist D.
europepmc   +1 more source

Pharmacokinetic Assessment of Atazanavir and Favipiravir Following Echinacea Supplementation: A Controlled Herb–Drug Interaction Investigation

Biopharmaceutics &Drug Disposition, EarlyView.
Pharmacokinetic interactions between Echinacea and two antiviral drugs, favipiravir and atazanavir, were assessed in rats. The findings suggest that Echinacea does not significantly affect the pharmacokinetics of favipiravir and atazanavir. These results provide preliminary evidence that concurrent use of Echinacea with these antiviral drugs may be ...
Siva Nageswara Rao Gajula, Jeevan Sai Kallam, Aarika Kanukolanu, Ganesh Korada, Lakshmi Vineela Nalla   +4 more
wiley   +1 more source

Trends in U.S. HIV diagnoses, 2005-2014 [PDF]

More than three decades after the first cases of AIDS were diagnosed in the United States, HIV continues to pose a substantial threat to the health and well-being of Americans.

core  

Rising HIV infections and shifting transmission patterns in Bangladesh: Emerging risks among key populations. [PDF]

Prev Med Rep
Hawk A, Akter M, Adebayo UO, Jamil S.
europepmc   +1 more source

Vasculitis-Like Hemorrhagic Herpes Zoster and HIV Infections: An Intricate Association. [PDF]

Cureus, 2023
Cozma EC, Banciu LM, Soare C, Găman MA, Voiculescu VM.   +4 more
europepmc   +1 more source

Fouling‐Free Inertial Microfluidic Cell Clarification for Lentivirus Manufacturing

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Lentiviral vectors (LVVs) are widely used as gene‐delivery vehicles in cell and gene therapy, enabling stable integration of transgenes into target cells. However, efficient clarification of LVV harvest remains a major bottleneck in large‐scale manufacturing, as conventional depth filtration often results in significant product loss.
Dohyun Park, Alexander Bevacqua, Mingyang Cui, Marina Nichols, Jianzhu Chen, Jongyoon Han   +5 more
wiley   +1 more source

Geospatial and phylogenetic clustering of acute and recent HIV infections in Lilongwe, Malawi. [PDF]

PLOS Glob Public Health
Bell GJ, Powers KA, Ratmann O, Dennis AM, Mmodzi P, Matoga M, Jere E, Chen JS, Maierhofer CN, Rutstein SE, Lancaster KE, Chagomerana MB, Bonongwe N, Mathiya E, Ndalama B, Bonsall D, Weir SS, Hosseinipour MC, Emch M, Cohen MS, Hoffman IF, Miller WC.   +21 more
europepmc   +1 more source

The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome

Biological Reviews, EarlyView.
ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke, Søren B. Hansen, Morten T. Limborg   +2 more
wiley   +1 more source