Results 291 to 300 of about 766,604 (355)

Saliva MicroAge: A salivary microbiome based machine learning model for noninvasive aging assessment and health state prediction

iMetaOmics, EarlyView.
Saliva MicroAge is a machine learning‐based model designed to estimate biological age and assess health status using globally sourced salivary microbiome data. Trained on 4532 healthy samples, the model achieves high accuracy in predicting chronological age and captures health‐related deviations (MicroAgeGap) in various diseases.
Tiansong Xu, Yuting Niu, Chenyu Deng, Yoo Cheung, Yuman Li, Zhewen Hu, Shiyu Sun, Yiming Chen, Fan He, Gai Yang, Feng Chen, Chenggang Duan, Ying Huang, Xuliang Deng   +13 more
wiley   +1 more source

Nationwide profiling of vaginal microbiota in Chinese women reveals age‐dependent shifts and predictive biomarkers for reproductive health

iMeta, EarlyView.
The vaginal microbiome is central to reproductive health, yet large‐scale studies in East Asian populations remain scarce. Here, we characterized the vaginal microbiota of 6423 Chinese women of reproductive age across 18 provinces and assessed associations with 33 host factors.
Cancan Qi, Yingxuan Zhang, Wei Qing, Rongdan Chen, Zuyi Zhou, Yumei Liu, Enzhong Chen, Wenyi Chen, CALM2004 Consortium Investigators, Hongwei Zhou, Muxuan Chen   +10 more
wiley   +1 more source

New HIV Infections Among Key Populations and Their Partners in 2010 and 2022, by World Region: A Multisources Estimation. [PDF]

J Acquir Immune Defic Syndr
Korenromp EL, Sabin K, Stover J, Brown T, Johnson LF, Martin-Hughes R, Ten Brink D, Teng Y, Stevens O, Silhol R, Arias-Garcia S, Kimani J, Glaubius R, Vickerman P, Mahy M.   +14 more
europepmc   +1 more source

Comprehensive Framework for Oncology Pharmacist‐Led Parenteral Anticancer Therapy Patient Education: The Opinion of the American College of Clinical Pharmacy Hematology/Oncology Practice and Research Network

JACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY, EarlyView.
This narrative review summarizes evidence for effective patient education on parenteral anticancer therapies. The authors propose a structured framework for oncology pharmacist‐led patient education on parenteral anticancer therapies that combines pharmacotherapy knowledge and the application of patient‐centered care.
Erin Hickey Zacholski, Jack Dierckes, David Hartnett‐Quach, Cady Noda, Amanda Sharps, Olivia White, Kyle Zacholski, Shawn P. Griffin   +7 more
wiley   +1 more source

Antifungal Resistance of Candida spp. Isolates From HIV/AIDS Patients in Iran 1999–2024: A Systematic Review and Meta‐Analysis

Journal of Clinical Laboratory Analysis, EarlyView.
Antimicrobial resistance in Candida spp. is significant in individuals with HIV/AIDS infections, particularly in Iran. In this systematic review, a comprehensive systematic search was conducted to identify all the eligible studies between 1999 and 2024; the pooled resistance rates of Candida spp. against antimicrobial agents were estimated. The risk of
Aliasghar Fakhri‐Demeshghieh, Ali Yousefipour, Yousef Bolouki, Mohammad Sadegh Bigdeli, Erfan Zamani, Amirreza Farajkhoda, Alireza Salmani, Farzad Katiraee, Saied Bokaie   +8 more
wiley   +1 more source

Nanomaterial‐Enhanced Electrochemical Sensors for Clinical Monitoring of Acyclovir: Integration Into Molecular Diagnostics

Journal of Clinical Laboratory Analysis, EarlyView.
Schematic illustration of biosensor technology for detection of ACV. ABSTRACT Objective This study investigates the innovative application of nanomaterial‐based micro‐devices aimed at enhancing the diagnosis and management of acyclovir (ACV) for herpes virus infections, specifically those caused by HSV‐1, HSV‐2, CMV, and VZV.
Mohammad Darvishi, Mohammad Mahdi Heidari, Reza Kheradmand, Nava Moghadasian Niaki, Mahsa Tabean, Ahmad Mobed   +5 more
wiley   +1 more source

Advances in Isothermal Amplification for the Diagnosis of Tuberculosis

Journal of Clinical Laboratory Analysis, EarlyView.
The emergence of isothermal amplification techniques presents a promising solution for tuberculosis (TB) diagnosis. These methods are attractive due to their simplicity, speed, and ability to perform without specialised equipment, which could make them suitable for low‐resource settings.
Nuttapon Jirakittiwut, Panan Ratthawongjirakul   +1 more
wiley   +1 more source

Clinical Evaluation of Drug–Drug Interactions Between Bictegravir and Strong Inhibitors/Inducers of the CYP3A4, UGT1A1, or P‐gp Pathways

The Journal of Clinical Pharmacology, EarlyView.
Abstract In addition to antiretroviral therapy (ART), people with HIV often take medications to treat comorbidities. It is therefore important to assess these medications for potential drug‐drug interactions, which may affect the safety and efficacy of ART. Three phase I studies were conducted in adult participants without HIV. The pharmacokinetics (PK)
Priyanka Arora, Hui Liu, John Ling, Jason T. Hindman, Dhananjay D. Marathe   +4 more
wiley   +1 more source

Recent Utilization of Pediatric Extrapolation and Modeling and Simulation Approaches in Pediatric Drug Development in Japan

The Journal of Clinical Pharmacology, EarlyView.
Abstract In Japan, the percentage of approved drugs with pediatric indications increased to 30% in 2010‐2015, but no further increase was observed through 2020. The Ministry of Health, Labor, and Welfare in Japan presented draft future directions to promote pediatric drug development, where the modeling and simulation (M&S) approach was introduced as a
Akinori Nakashima, Akihide Tsujimoto, Masako Saito, Jun Takeda, Makiko Natori, Satoshi Shoji   +5 more
wiley   +1 more source

Is It an Intrapericardial Mass or a Localized Pericardial Effusion? A Case Report of Tuberculous Pericarditis Evaluated by Multimodal Imaging

Journal of Clinical Ultrasound, EarlyView.
Tuberculous pericarditis is a common type of pericarditis, but it is difficult to be diagnosed. The application of combined transesophageal echocardiography, contrast echocardiography, and CT multimodal imaging provides sufficient clinical diagnosis basis and guidance for distinguishing encapsulated pericardial effusion or mass.
Yang Han, Bingbing Liu, Yonghuai Wang, Fei Xia, Jun Yang, Chunyan Ma   +5 more
wiley   +1 more source