Results 201 to 210 of about 26,857 (227)
Some of the next articles are maybe not open access.
Thiazolothiazepine Inhibitors of HIV-1 Integrase
Journal of Medicinal Chemistry, 1999A series of thiazolothiazepines were prepared and tested against purified human immunodeficiency virus type-1 integrase (HIV-1 IN) and viral replication. Structure-activity studies reveal that the compounds possessing the pentatomic moiety SC(O)CNC(O) with two carbonyl groups are in general more potent against purified IN than those containing only one
NEAMATI N. +12 more
openaire +4 more sources
Quinoline-based HIV Integrase Inhibitors
Current Pharmaceutical Design, 2013HIV integrase became an important target for drug development more than twenty years ago. However, progress has been hampered by the lack of assays suitable for high throughput screening, a reliable crystal structure or pharmacophore. Thus, a real breakthrough was only observed in 2007 with the introduction of the first integrase inhibitor, raltegravir,
openaire +2 more sources
The future of integrase inhibitors of HIV-1
Current Opinion in Virology, 2012Integration of the HIV-1 DNA is required and essential to maintain the viral DNA in the infected cell. Integration process occurs in several events, mainly endonucleolytic processing of the 3' ends of the viral DNA and strand transfer or joining of the viral and cellular DNA.
Isabelle, Malet +2 more
openaire +2 more sources
2022
HIV infection is incredibly detrimental and fatal to people. Unfortunately, despite recent advancements and medications, it has not yet been completely eradicated. Opportunistic infections are added to the list of disorders in AIDS (Acquired Immune Deficiency Syndrome), an infectious disease that develops as a result of an impaired immune system.
openaire +1 more source
HIV infection is incredibly detrimental and fatal to people. Unfortunately, despite recent advancements and medications, it has not yet been completely eradicated. Opportunistic infections are added to the list of disorders in AIDS (Acquired Immune Deficiency Syndrome), an infectious disease that develops as a result of an impaired immune system.
openaire +1 more source
HIV integrase as a target for antiretroviral therapy
Current Opinion in HIV and AIDS, 2012Integrase strand transfer inhibitors are the most recent class of antiretroviral agents to be introduced into clinical practice. This review describes the discovery of the first inhibitors and insights into their distinct mechanism of action with potential translational implications.HIV replication depends on the successful integration of the viral ...
openaire +2 more sources
Recent Advances in Small-Molecule HIV-1 Integrase Inhibitors
Current Medicinal Chemistry, 2021Chao Zhang, Qian Xie, Zhe Jin
exaly
Resistance to HIV-1 integrase inhibitors: A structural perspective
Drug Resistance Updates, 2010Jean-François Mouscadet +2 more
exaly