Results 251 to 260 of about 86,566 (299)

Quinoline-based HIV Integrase Inhibitors

Current Pharmaceutical Design, 2013
HIV integrase became an important target for drug development more than twenty years ago. However, progress has been hampered by the lack of assays suitable for high throughput screening, a reliable crystal structure or pharmacophore. Thus, a real breakthrough was only observed in 2007 with the introduction of the first integrase inhibitor, raltegravir,
R. Musioł
openaire   +3 more sources

Incidence of dyslipidemia in people with HIV who are treated with integrase inhibitors versus other antiretroviral agents

AIDS (London), 2021
Supplemental Digital Content is available in the text Objective: To compare the incidence of dyslipidemia in people with HIV receiving integrase inhibitors (INSTI) versus boosted protease inhibitors (PI/b) and nonnucleoside reverse transcriptase ...
D. Byonanebye
semanticscholar   +1 more source

Impact of Integrase inhibitors and tenofovir alafenamide on weight gain in people with HIV

Current Opinion in HIV and AIDS, 2021
Purpose of review Obesity is increasing in people with HIV (PWH). This review aims to summarise the recent evidence investigating the associations between the use of integrase inhibitors and tenofovir alafenamide (TAF) with weight gain and the mechanisms
J. Lake, J. Trevillyan
semanticscholar   +1 more source

Novel integrase inhibitors for HIV

Expert Opinion on Investigational Drugs, 2010
Integrase inhibitors are the newest class of antiretroviral agents developed to treat HIV-1 infection. Raltegravir (RAL), the only integrase inhibitor (INI) currently approved for the treatment of HIV-infected patients, has proven to be a potent and well-tolerated antiretroviral (ARV) agent.
Nicole, Prada, Martin, Markowitz
openaire   +2 more sources

Potential Inhibitors of HIV Integrase

Nucleosides and Nucleotides, 1999
In the search for inhibitors of HIV integrase, the enzyme involved in the integration of viral DNA into host DNA, we have synthesized and studied a number of analogs of the heterocyclic molecule, chloroquine.
C, Mathé, V, Nair
openaire   +2 more sources