Results 281 to 290 of about 86,566 (299)

Styrylquinazoline Derivatives as HIV-1 Integrase Inhibitors

Archiv der Pharmazie, 2002
Styrylquinazoline derivatives were prepared by Perkin condensation and evaluated for inhibitory activity against HIV-1 integrase. Among them, compound 5c containing a free catechol ring was the most potent (IC(50)=0.8 +/- 1.9 microM)and showed 6-fold more potency than the corresponding styrylquinoline compound (IC(50) = 130.7 +/- 8.6 microM).
Jae Yeol, Lee, Jang Hyun, Park, Sook Ja, Lee, Hokoon, Park, Yong Sup, Lee   +4 more
openaire   +2 more sources

HIV‐1 Integrase Inhibitors: Update and Perspectives

2008
Publisher Summary The chapter focuses on the recent advances in understanding the cellular mechanisms of human immunodeficiency virus (HIV) integration and the sites of actions of inhibitors. The chapter presents list of the known mutations that have been characterized for HIV‐1 integrase (IN) with their impact on IN activity, viral replication, and ...
Elena A, Semenova, Christophe, Marchand, Yves, Pommier   +2 more
openaire   +2 more sources

Patented HIV-1 Integrase Inhibitors (1998-2005)

Recent Patents on Anti-Infective Drug Discovery, 2006
Combination therapy, comprising at least three anti-human immunodeficiency virus (anti-HIV) drugs, has become the standard treatment of AIDS. Since 1996, highly active antiretroviral therapy (HAART) was designed to rapidly control HIV replication. It has had a significant impact on patient health and progression of AIDS in developed countries but its ...
openaire   +2 more sources

HIV Integrase Inhibitors

2014
Rajni Garg, Gene M. Ko
openaire   +2 more sources

Investigational HIV integrase inhibitors in phase I and phase II clinical trials

Expert Opinion on Investigational Drugs, 2017
Yingshan Han, T. Mesplède, M. Wainberg
semanticscholar   +1 more source

HIV integrase inhibitors: a new era in the treatment of HIV

Expert Opinion on Pharmacotherapy, 2015
J. Blanco, G. Whitlock, A. Milinkovic, G. Moyle   +3 more
semanticscholar   +1 more source

HIV-1 integrase strand transfer inhibitors: A review of current drugs, recent advances and drug resistance.

International Journal of Antimicrobial Agents, 2021
N. Mbhele, B. Chimukangara, M. Gordon
semanticscholar   +1 more source

HIV Integrase Inhibitors and Entry Inhibitors

2021
Daniel Bradshaw, Ranjababu Kulasegaram
openaire   +1 more source

Modeling, analysis, and validation of a novel HIV integrase structure provide insights into the binding modes of potent integrase inhibitors.

Journal of Molecular Biology, 2008
Xiaowu Chen, M. Tsiang, F. Yu, Magdeleine Hung, G. S. Jones, A. Zeynalzadegan, X. Qi, H. Jin, C. U. Kim, S. Swaminathan, James M. Chen   +10 more
semanticscholar   +1 more source

HIV-1 integrase inhibitor

Drug Discovery Today, 1996
openaire   +1 more source