Results 151 to 160 of about 651,532 (328)

Erratum to: HIV Prevention Among Transgender Populations: Knowledge Gaps and Evidence for Action [PDF]

, 2017
Tonia Poteat, Mannat Malik, Ayden I. Scheim, Ayana Elliott   +3 more
openalex   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

Health disparities in chronic liver disease

Hepatology, EarlyView., 2022
Abstract The syndemic of hazardous alcohol consumption, opioid use, and obesity has led to important changes in liver disease epidemiology that have exacerbated health disparities. Health disparities occur when plausibly avoidable health differences are experienced by socially disadvantaged populations.
Ani Kardashian, Marina Serper, Norah Terrault, Lauren D. Nephew   +3 more
wiley   +1 more source

Transforming RNA Degradation into Accurate RNA Detection: RNase I–Assisted Rolling Circle Amplification for Clinical Samples

Angewandte Chemie, EarlyView.
Here, we transform this otherwise destructive enzymatic activity into a powerful diagnostic advantage through an RNase I–assisted rolling circle amplification (RI‐RCA) strategy. By integrating controlled RNase I–mediated RNA digestion with circular DNA templates, this approach enables direct and highly sensitive detection of target RNA sequences. Using
Amal Mathai, Cheng‐Yu Lee, Zijie Zhang, Jimmy Gu, John D. Brennan, Yingfu Li   +5 more
wiley   +2 more sources

Machine Learning‐Enhanced Random Matrix Theory Design for Human Immunodeficiency Virus Vaccine Development

Advanced Intelligent Discovery, EarlyView.
This study integrates random matrix theory (RMT) and principal component analysis (PCA) to improve the identification of correlated regions in HIV protein sequences for vaccine design. PCA validation enhances the reliability of RMT‐derived correlations, particularly in small‐sample, high‐dimensional datasets, enabling more accurate detection of ...
Mariyam Siddiqah, Muhammad Zulqarnain Zeb, Muhammad Husnain Zeb, Babar Shabbir   +3 more
wiley   +1 more source

Identification of novel neutralizing determinants for protection against HCV

Hepatology, EarlyView., 2022
Identification of novel neutralizing determinants for protection against hepatitis C virus. Abstract Background and Aims HCV evasion of neutralizing antibodies (nAb) results in viral persistence and poses challenges to the development of an urgently needed vaccine.
Garazi P. Alzua, Anne F. Pihl, Anna Offersgaard, Rodrigo Velázquez‐Moctezuma, Carlos R. Duarte Hernandez, Elias H. Augestad, Ulrik Fahnøe, Christian K. Mathiesen, Henrik Krarup, Mansun Law, Jannick Prentoe, Jens Bukh, Judith M. Gottwein   +12 more
wiley   +1 more source

Navigating an STI diagnosis: The role of social support, intergenerational learning, and transformative growth among Black women

American Journal of Community Psychology, EarlyView.
Abstract Black women face a myriad of challenges that heighten their susceptibility to sexually transmitted infections (STIs), resulting in a disproportionate impact of STIs among this population. Yet, there is a lack of research that explores how women navigate these diagnoses with resilience.
Jaleah D. Rutledge, Jasmine Abrams, Ijeoma Opara, Robin Lin Miller   +3 more
wiley   +1 more source

Nicotinamide riboside and pterostilbene reduces markers of hepatic inflammation in NAFLD: A double‐blind, placebo‐controlled clinical trial

Hepatology, EarlyView., 2022
NRPT 1X reduces ALT and ceramide 14:0 in 65% of subjects as compared to only 28% in the placebo group. Abstract Background and Aims The prevalence of NAFLD is increasing globally and on a path to becoming the most frequent cause of chronic liver disease. Strategies for the prevention and treatment of NAFLD are urgently needed.
Ryan W. Dellinger, Holly E. Holmes, Tina Hu‐Seliger, Rodney W. Butt, Stephen A. Harrison, Dariush Mozaffarian, Oliver Chen, Leonard Guarente   +7 more
wiley   +1 more source

Meeting Men Where they are: Motivators and Barriers to Accessing Health Services through a Men’s Mobile Wellness Clinic, October 2019 to March 2020, Blantyre, Malawi

Journal of Epidemiology and Global Health
Background In Malawi approximately, 88.3% people living with HIV are aware of their HIV status. Significant gaps are among men aged 15–34 years; only 72% know their HIV status.
Mtemwa Nyangulu, Tiffiany Aholou, Viva Thorsen, Shahul Ebrahim, Ernest Nkhoma, Chipiliro Payesa, Getrude Chipungu, Masozie Kalua, Jeroen van ’t Pad Bosch, Hannah Gibson, Verita Buie, Fidelis Sindani, Helen Dale, Stephanie Behel, Rashida Hassan, Alice Maida, Kristina Grabbe   +16 more
doaj   +1 more source

The epidemiological impact of an HIV vaccine on the HIV/AIDS epidemic in Southern India [PDF]

The potential epidemiological impact of preventive HIV vaccines on the HIV epidemic in Southern India is examined using a mathematical deterministic dynamic compartmental model. Various assumptions about the degree of protection offered by such a vaccine,
De Vlas, Sake J., Nagelkerke, Nico J.D.
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