Results 141 to 150 of about 2,320,248 (308)

A White Paper on Advancing Long‐Acting Therapeutics for Maternal and Pediatric Health by Bridging Gaps in Clinical Research, Access and Regulation

Clinical Pharmacology &Therapeutics, EarlyView.
As use cases for long‐acting therapeutics expand across clinical indications, there is a critical need to ensure the inclusion of women who are pregnant or breastfeeding, infants and children—populations with a historical gap in the availability of interventions already approved for use in adults.
Moherndran Archary, Robert Bies, Osei Boateng, Rachel Daley, Pierre Gashema, Mili Karina, Emily Njuguna, Sharon Nachman, Nathaniel Nkrumah, Carolyne Odula, Andrew Owen, Ethel D. Weld, Prajith Venkatasubramanian, Adeniyi Olagunju, on behalf of the Community of Practice for Long‐acting Therapeutics for Maternal and Paediatric Health, Rana Abutaima, Dorothy Akongo, Abdulnaser Alsharaa, Moherndran Archary, Shakir Atoyebi, Benoit Bestgen, Robert Bies, Osei Boateng, Andrew Butler, Edmund Capparelli, Rachel Daley, Layla Davies, Joelle Dountio, Henry Enzama, Pierre Gashema, Katila George, Dan Hawcutt, Rene Holm, Patrick Gad Iradukunda, Elodie Jambert, Mili Karina, Linda Lewis, Grace Miheso, Sebastien Morin, Andrew Morrison, Sharon Nachman, Shadia Nakalema, Emily Njunga, Nathaniel Nkrumah, Carolyne Odula‐Obonyo, Brenda Okware, Adeniyi Olagunju, Andrew Owen, Martina Penazzato, Natella Rakhmanina, Mphako Brighton Ratlabyana, Rachel Scott, Kimberly Struble, Andre‐Marie Tchouatieu, Catherine Unsworth, Prajith Venkatasubramanian, Catriona Waitt, Ethel Weld, Janine Winterbottom, Leena Zino   +59 more
wiley   +1 more source

Delivery of HIV partner services in the United States and dependent areas 2021 [PDF]

In 2020, there were 30,692 persons with newly diagnosed HIV infection in the United States.1 Most infections occur following exposure to HIV from persons who are infected but not receiving medical care.2 Some of these persons have HIV that has not been ...

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Long‐Acting Therapeutics in Pediatric Health: Bridging Innovation and Access

Clinical Pharmacology &Therapeutics, EarlyView.
Children have distinct therapeutic needs arising from age‐dependent physiology, disease epidemiology, formulation requirements, dosing considerations, and safety vulnerabilities. Despite substantial reductions in childhood mortality over the past three decades, nearly 5 million children under five died in 2023, with infectious diseases continuing to ...
Prajith Venkatasubramanian, Moherndran Archary, Daniel B. Hawcutt, Rachel Daley, Edmund Capparelli, Adeniyi Olagunju   +5 more
wiley   +1 more source

Pharmacokinetics of Rifapentine and Desacetyl Rifapentine in Maternal Plasma and Breast Milk & Infant Cord Blood and Plasma: A Model‐Based Analysis of Mother–Infant Pairs for Tuberculosis Prevention

Clinical Pharmacology &Therapeutics, EarlyView.
IMPAACT 2001 (NCT02651259) evaluated the safety and pharmacokinetics (PK) of once‐weekly isoniazid and rifapentine in pregnant and postpartum women for tuberculosis prevention. Rifapentine (RPT) and desacetyl rifapentine (desRPT) PK data were collected in maternal plasma, breast milk, infant cord blood, and infant plasma.
Priya Jayachandran, Jyoti S. Mathad, Nan Zhang, Paula Britto, Lubbe Wiesner, Grace Montepiedra, Jennifer Norman, Ellen Townley, Sarah Bradford, Sandesh Patil, Stephanie Popson, Tsungai Chipato, Vanessa Rouzier, Deborah Langat, Amphan Chalermchockcharoentkit, Amita Gupta, Kelly E. Dooley, Radojka Savic, on behalf of the IMPAACT 2001 Study Team   +18 more
wiley   +1 more source

HIV/AIDS and STD Semiannual Report Incident, Prevalent, and Cumulative AIDS Cases in Kansas as of ... by Date of Report HIV/AIDS in Kansas Biannual Report ... HIV/AIDS in Kansas Annual Report ...

, 2009
Contains Incident, Prevalent, and Cumulative AIDS Cases in Kansas as of ... by Date of Report "HIV/AIDS and STD Semiannual Report is a publication of the Kansas Department of Health and Environment with funding assistance from the Centers for Disease ...
HIV/AIDS Surveillance Program
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Pharmacist's role in managing drug–drug interactions in people with HIV receiving antiretroviral therapy or HIV pre‐exposure prophylaxis: A focus on polypharmacy and transitions of care in the United States

British Journal of Clinical Pharmacology, EarlyView.
Shawnalyn W. Sunagawa, Elizabeth M. Sherman, Melissa Badowski, David B. Cluck, Spencer H. Durham, Joshua P. Havens, Emily Huesgen, Justin K. Ma, Roxane Rohani, Eric G. Sahloff, Kristy M. Shaeer, Radhika S. Polisetty   +11 more
wiley   +1 more source

Evaluating Vaginal Microbiome Effects on Antiretroviral Exposure in the Female Genital Tract Using Pharmacometric and Machine Learning Approaches

Clinical Pharmacology &Therapeutics, EarlyView.
Antiretroviral pre‐exposure prophylaxis (PrEP) is less effective in women than expected, partly because drug exposure within the female genital tract is variable and may be influenced by the vaginal microbiome. We developed an integrated pharmacometrics and machine learning framework to evaluate associations between vaginal microbiome composition and ...
Diqin Yan, Lindsey B. Collins, Christopher Staley, Flavia Kiweewa Matovu, Pamala Jacobson, Melanie Nicol, Shen Cheng   +6 more
wiley   +1 more source

HIV/AIDS and STD Semiannual Report Incident, Prevalent, and Cumulative AIDS Cases in Kansas as of ... by Date of Report HIV/AIDS in Kansas Biannual Report ... HIV/AIDS in Kansas Annual Report ...

, 2008
Contains Incident, Prevalent, and Cumulative AIDS Cases in Kansas as of ... by Date of Report "HIV/AIDS and STD Semiannual Report is a publication of the Kansas Department of Health and Environment with funding assistance from the Centers for Disease ...
[HIV/AIDS Surveillance Program]
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Impact of Food and Beverage on Enlicitide Pharmacokinetics and LDL‐C Lowering

Clinical Pharmacology &Therapeutics, EarlyView.
Enlicitide decanoate is a macrocyclic peptide first‐in‐class oral PCSK9 inhibitor that lowers LDL‐C, with maximal efficacy achieved when administered on an empty stomach. This work characterizes the effects of food, pre‐dose fasting duration (2–8 hours), water volume, common beverages (black coffee and plain tea), and other real‐world scenarios on ...
Douglas G. Johns, Maja Skataric, Susan Zhou, Ferdous Gheyas, Ednan Bajwa, Puja Banka, Filippos Kesisoglou, Allen Hunt, David Bruce, Corey Anderson, Helen Manthos, Jonathan Pollock, Paul J. Donabella, Campbell Thompson, Daniel Freire, Kiet Giang, Frank Pietrantonio, Dennis Wolford, Piyali Basak, Maxwell Pistilli, Bhavna Kantesaria, Prajakti Kothare, Islam R. Younis   +22 more
wiley   +1 more source

Disability and Biomedical HIV Prevention: The Missing Equity Dimension. [PDF]

Viruses
De Maria F, Fusco P, Russo A.
europepmc   +1 more source