Results 121 to 130 of about 636,107 (305)

Nonviral Gold Nanoparticle‐Mediated Delivery of CRISPR‐Cas9 Ribonucleoprotein and Long DNA Transgenes Into Primary Blood Cells

Advanced NanoBiomed Research, EarlyView.
CRISPR/Cas9 has revolutionized the field of gene therapy, but delivery remains an outstanding issue. We propose a nonviral gold‐nanoparticle platform for co‐delivery of CRISPR/Cas9 ribonucleoprotein and long 2.1 kilobase dsDNA transgene constructs. This CRISPR‐AuNP is inexpensive to produce and mediate gene editing and DNA delivery in T cells and CD34+
Rachel A. Cunningham, Karthikeya S. V. Gottimukkala, Daniel D. Lane, Katrina Poljakov, Patricia Lipson, Mark R. Enstrom, Alessandro Rizzi, Aude G. Chapuis, Jennifer E. Adair   +8 more
wiley   +1 more source

The effects of HIV self-testing on HIV incidence and awareness of status among men who have sex with men in the United States: Insights from a novel compartmental model

Epidemics
Background: The OraQuick In-Home HIV self-test represents a fast, inexpensive, and convenient method for users to assess their HIV status. If integrated thoughtfully into existing testing practices, accompanied by efficient pathways to formal diagnosis ...
Alex Viguerie, Chaitra Gopalappa, Cynthia M. Lyles, Paul G. Farnham   +3 more
doaj   +1 more source

Immunoinformatics‐Based Design of a Multi‐Epitope Vaccine Targeting a Conserved Copper–Associated Protein in Neisseria gonorrhoeae

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Neisseria gonorrhoeae poses an urgent public health challenge due to rapidly increasing antimicrobial resistance and the absence of an effective vaccine. Targeting conserved bacterial pathways involved in essential physiological processes may provide new opportunities for vaccine antigen discovery.
Sinethemba H. Yakobi, Uchechukwu U. Nwodo   +1 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Analysis of Factors Influencing the Acceptance of Voluntary Counseling and Testing Among Sexually Active College Students in Zhejiang Province, China

HIV/AIDS: Research and Palliative Care
Jiajin He,1,* Xin Zhou,2,* Lingjuan Chen,3 Qiaoqin Ma,2 Liebo Zhu,1 Junfang Lou,1 Lianqi Zha,1 Jieyun Lou,1 Nan Zheng,1 Weiyong Chen2,4 1Yiwu Center for Disease Control and Prevention, Yiwu, Zhejiang, People’s Republic of China ...
He J, Zhou X, Chen L, Ma Q, Zhu L, Lou J, Zha L, Lou J, Zheng N, Chen W   +9 more
doaj  

Testing trends and co-testing patterns for HIV, hepatitis C and sexually transmitted infections (STIs) in Emergency departments

Preventive Medicine Reports
Background: Many underserved populations use Emergency Department (EDs) as primary sources of care, representing an important opportunity to provide infectious disease testing and linkage to care.
Hasan Symum, Michelle Van Handel, Amy Sandul, Angela Hutchinson, Clarisse A. Tsang, William S. Pearson, Kevin P. Delaney, Laura A. Cooley, Thomas L. Gift, Karen W. Hoover, William W. Thompson   +10 more
doaj   +1 more source

Population pharmacokinetics of levofloxacin in breastmilk in patients with rifampicin‐resistant tuberculosis

British Journal of Clinical Pharmacology, EarlyView.
Levofloxacin is a widely used antibiotic included in rifampicin‐resistant tuberculosis (RR‐TB) treatment. Data describing levofloxacin concentrations in breastmilk and infant exposure are limited. We analysed data from two South African studies of breastfeeding women receiving levofloxacin (750–1000 mg daily) for RR‐TB.
Sharon Sawe, Lufina Tsirizani, Buyisile Mkhize, Lubbe Wiesner, Gary Maartens, Francesca Conradie, Richard Court, Marian Loveday, Catriona Waitt, Paolo Denti   +9 more
wiley   +1 more source

The determinants of HIV infection and related sexual behaviors : evidence from Lesotho [PDF]

This paper analyzes the socioeconomic determinants of HIV infection and related sexual behaviors using the 2004Lesotho Demographic and Health Survey.
Corno, Lucia, de Walque, Damien
core  

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Status and comparison of HIV Knowledge, HIV Testing and other healthy behavior between men who have sex with men only (MSMO) and men who have sex with men and women (MSMW): a cross-sectional study in Zhejiang Province, China

BMC Public Health
Objective This study was conducted to explore the human immunodeficiency virus (HIV) status of and compare HIV knowledge, HIV testing, and other healthy behaviors between men who have sex with men and women (MSMW) and men who have sex with men only (MSMO)
Zhongrong Yang, Lin Chen, Wanjun Chen, Lin He, Chengliang Chai   +4 more
doaj   +1 more source