Results 21 to 30 of about 2,320,248 (308)

HIV testing during pregnancy among women with a recent live birth—Seven US States, 2016–2019

Women's Health, 2023
Background: Although the United States has made progress in reducing the transmission of HIV from mother-to-child, it has not yet met the goal of reducing such transmissions to 70%. Self-reported HIV testing varied by state of residence.
Ndidi Nwangwu-Ike, Martha Kapaya, Keydra Oladapo, Denise V DAngelo   +3 more
doaj   +1 more source

SHIV remission in macaques with early treatment initiation and ultra long-lasting antiviral activity

Nature Communications
Studies in SIV-infected macaques show that the virus reservoir is particularly refractory to conventional suppressive antiretroviral therapy (ART). We posit that optimized ART regimens designed to have robust penetration in tissue reservoirs and long ...
Michele B. Daly, Chuong Dinh, Angela Holder, Donna Rudolph, Susan Ruone, Alison Swaims-Kohlmeier, George Khalil, Sunita Sharma, James Mitchell, Jillian Condrey, Daniel Kim, Yi Pan, Kelly Curtis, Peter Williams, William Spreen, Walid Heneine, J. Gerardo García-Lerma   +16 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Human immunodeficiency virus is a driven factor of human papilloma virus among women: evidence from a cross-sectional analysis in Yaoundé, Cameroon

Virology Journal, 2020
Background Human papillomavirus (HPV) is the leading cause of cervical cancers, causing 270.000 deaths annually worldwide of which 85% occur in developing countries with an increasing risk associated to HIV infection.
Samuel Martin Sosso, Michel Carlos Tommo Tchouaket, Joseph Fokam, Rachel Kamgaing Simo, Judith Torimiro, Aline Tiga, Elise Elong Lobe, Georgia Ambada, Achille Nange, Ezechiel Ngoufack Jagni Semengue, Alex Durand Nka, Valère Tala, Collins Chenwi, Aissatou Abba, Aude Christelle Ka’e, Bouba Yagai, Vittorio Colizzi, Alexis Ndjolo   +17 more
doaj   +1 more source

Microbicides for HIV prevention

The Indian Journal of Medical Research, 2011
Although the HIV incidence rate has slowed in some countries, HIV remains a serious health challenge, particularly in the developing world. The epidemic is increasingly feminised, with young women at high risk of acquiring the virus. There is thus a clear requirement for acceptable woman-initiated methods of HIV prevention.
openaire   +2 more sources

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Oral Islatravir in Macaques Decreases Lymphocytes and Monocytes and Is Associated with Immune Alterations

Pharmaceutics
Background: Islatravir (ISL) is a first-in-class nucleoside reverse transcriptase translocation inhibitor with high potency and long half-life in peripheral blood mononuclear cells (PBMCs). However, treatment and prevention of HIV with oral ISL in humans
Michele B. Daly, Daniel Kim, Seidu Inusah, Dawn Little, Jiyoung S. Kim, Natalia Makarova, Tiancheng E. Edwards, James Mitchell, Walid Heneine, Yi Pan, Charles W. Dobard, J. Gerardo García-Lerma   +11 more
doaj   +1 more source

Evaluating the effect of the plan of national syphilis control in controlling the syphilis epidemic in Jiangsu, China 2010–2020

Frontiers in Public Health, 2023
BackgroundStarting in 2010, the Chinese government initiated a 10-year syphilis control plan, called the national syphilis control plan (NSCP), to address the emerging threat of syphilis.
Lingen Shi, Lingen Shi, Liping Chen, Xiaoyan Liu, Haiyang Hu, Yuheng Chen, Yunting Chen, Zhi Zhang, Ying Zhou, Jing Lu, Dandan Yang, Wenhui Guan   +11 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source