Results 221 to 230 of about 184,582 (277)

Pharmacovigilance study of INSTIs associated with weight gain and glucose/lipid metabolism adverse events based on the FDA adverse event reporting system

open access: yesHIV Medicine, Volume 27, Issue 5, Page 749-760, May 2026.
Abstract Objective Integrase strand transfer inhibitors (INSTIs) are widely used in antiretroviral therapy (ART) for people with HIV due to their efficacy and tolerability. However, concerns about weight gain and metabolic disturbances have emerged.
Leidan Zhang   +8 more
wiley   +1 more source

Perinatal and early infant outcomes after first‐versus second‐generation integrase strand transfer inhibitor use in pregnancy

open access: yesHIV Medicine, Volume 27, Issue 5, Page 761-770, May 2026.
Abstract Introduction Integrase strand transfer inhibitors (INSTIs) are first‐line antiretroviral medications used in pregnancy. Pre‐clinical research suggests adverse effects in human stem cells associated with second‐ versus first‐generation INSTIs.
Rosa Balleny   +12 more
wiley   +1 more source

Calibration and discrimination ability of the Dat'AIDS score in people living with HIV aged 70 years and older from the Dat'AIDS cohort

open access: yesHIV Medicine, Volume 27, Issue 5, Page 771-784, May 2026.
Abstract Objective The Dat'AIDS score was developed to predict 5‐year mortality risk in people living with HIV aged 60 and older. However, its validity in people living with HIV aged 70 years and older needed confirmation. Methods This was a multicentre prospective cohort study in the Dat'AIDS French cohort.
Abeo Mousse   +337 more
wiley   +1 more source

Postoperative Pain After Endodontic Treatment in HIV‐Positive Patients Under HAART: A Prospective Observational Cohort Study

open access: yesInternational Endodontic Journal, Volume 59, Issue 5, Page 788-793, May 2026.
ABSTRACT Aim To compare post‐operative pain following root canal treatment (RCT) in HIV‐positive patients receiving highly active antiretroviral therapy (HAART) and HIV‐negative patients and to assess the influence of systemic condition on endodontic pain.
Marcos Felipe Iparraguirre Nuñovero   +5 more
wiley   +1 more source

Combination antiretroviral therapy and the risk of myocardial infarction [PDF]

open access: yes, 2003
Abbadesse, V   +535 more
core  

A Multifaceted Holistic Review of the Literature on Scar Dermatoses

open access: yesInternational Wound Journal, Volume 23, Issue 5, May 2026.
ABSTRACT Many cutaneous diseases originate or manifest in scars. Scars are areas of compromised skin, which renders them a vulnerable cutaneous district for diseases to develop. The pathophysiology explaining why some dermatoses grow in scars is not yet thoroughly explored. The present study reviews the present literature on scar dermatoses.
Dana Maria Khoury   +5 more
wiley   +1 more source

Cucumber Mosaic Virus Coat Protein Sequesters Host CDPK7‐Like Into Phase‐Separated Condensates to Promote Viral Infection

open access: yesMolecular Plant Pathology, Volume 27, Issue 5, May 2026.
This study reveals a tripartite pesticide–pathogen–host interaction in which the host kinase CDPK7‐like in Nicotiana benthamiana interacts with cucumber mosaic virus coat protein (CMV CP) to form LLPS‐driven condensates that facilitate viral infection.
Lei Zhao   +7 more
wiley   +1 more source

HIV-Protease Inhibitors

New England Journal of Medicine, 1998
Inhibitors of human immunodeficiency virus (HIV)–encoded protease, combined with nucleoside analogues with antiretroviral activity, cause profound and sustained suppression of viral replication, reduce morbidity, and prolong life in patients with HIV infection.1–3 Recent guidelines recommend that initial treatment of all HIV-infected patients include ...
Charles Flexner
exaly   +6 more sources

Inhibition of HIV‐2 Protease by HIV‐1 Protease Inhibitors in Clinical Use

Chemical Biology and Drug Design, 2008
Over the past 10 years, protease inhibitors have been a key component in antiretroviral therapies for HIV/AIDS. While the vast majority of HIV/AIDS cases in the world are due to HIV‐1, HIV‐2 infection must also be addressed. HIV‐2 is endemic to Western Africa, and has also appeared in European countries such as Portugal, Spain, and Estonia.
Ernesto Freire
exaly   +3 more sources

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