Results 71 to 80 of about 7,403,959 (300)

Couple experiences of provider-initiated couple HIV testing in an antenatal clinic in Lusaka, Zambia: lessons for policy and practice. [PDF]

, 2013
BACKGROUND: Couple HIV testing has been recognized as critical to increase uptake of HIV testing, facilitate disclosure of HIV status to marital partner, improve access to treatment, care and support, and promote safe sex. The Zambia national protocol on
Merten, Sonja, Virginia Bond, Sonja Merten, Bond, Virginia, Bond, V., Musheke, M., Maurice Musheke, Merten, S., Musheke, Maurice   +8 more
core   +2 more sources

On‐Chip Photonic Neural Network Architectures

Advanced Optical Materials, EarlyView.
This review presents a comprehensive overview of on‐chip photonic neural network architectures, covering key photonic building blocks, representative network types, and emerging applications. Recent advances, implementation challenges, and future directions are examined, highlighting the potential of integrated photonics to enable ultrafast, energy ...
Seokjin Hong, Berkay Neseli, Seungyeon Cho, Seungsoo Lee, Yeonjun Kim, Seungyoon Choi, Hyo‐Hoon Park, Hamza Kurt   +7 more
wiley   +1 more source

An exploration of the perceptions and experiences of community members on acceptability and feasibility of HIV Self-Testing Oral Fluid Test in Neta ward Mberengwa District, Zimbabwe [PDF]

, 2018
Master of Public Health - MPHBackground: The identification of undiagnosed HIV positive individuals through HIV testing services is one of the key measures in ensuring that the UNAIDS/ WHO 90 90 90 targets are achieved by the year 2020.
Tshuma, Mboneni Ona
core  

Deep Contrastive Learning for High‐Throughput Prediction of Drug Resistance Mutations from Sequences

Advanced Science, EarlyView.
This study presents DeepMutDTA, a deep learning framework aimed at predicting mutation‐induced changes in protein‐drug interactions and prioritizing variants potentially linked to drug resistance. Trained on large‐scale data, it incorporates SimSiam‐MuTF, a label‐aware contrastive fine‐tuning strategy that encourages separation between WT and MT ...
Xiaowen Hu, Pan Zhang, Shangqian Wu, Hao Sun, Minwei Li, Sophia Tsoka, Zizhang Sheng, Lei Deng   +7 more
wiley   +1 more source

Cost-effectiveness of voluntary HIV-1 counseling and testing in reducing sexual transmission of HIV-1 in Kenya and Tanzania. [PDF]

, 2000
Background Access to HIV-1 voluntary counseling and testing (VCT) is severely limited in less-developed countries. We undertook a multisite trial of HIV-1 VCT to assess its impact, cost, and cost-effectiveness in less-developed country settings.\ud ...
Sangiwa , G, Balmer, D, Sweat , M, Furlonge , C, Coates , T, Kamenga , C, Gregorich , S, Grinstead, O   +7 more
core  

Do accurate HIV and antiretroviral therapy knowledge, and previous testing experiences increase the uptake of HIV voluntary counselling and testing? Results from a cohort study in rural Tanzania. [PDF]

, 2013
BACKGROUND: Despite the introduction of free antiretroviral therapy (ART), the use of voluntary counselling and testing (VCT) services remains persistently low in many African countries.
Zaba, B, Manyalla, R, Urassa, M, Cawley, Caoimhe, Wringe, A, Isingo, R, Caoimhe Cawley, South, A, Todd, Jim, Urassa, Mark, Isingo, Raphael, Wringe, Alison, Alison Wringe, Mark Urassa, Zaba, Basia, Yusufu Kumogola, Raphael Isingo, Rose Manyalla, Annabelle South, Manyalla, Rose, South, Annabelle, Kumogola, Yusufu, Cawley, C, Basia Zaba, Kumogola, Y, Jim Todd, Todd, J   +26 more
core   +2 more sources

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

The effects of HIV self-testing on HIV incidence and awareness of status among men who have sex with men in the United States: Insights from a novel compartmental model

Epidemics
Background: The OraQuick In-Home HIV self-test represents a fast, inexpensive, and convenient method for users to assess their HIV status. If integrated thoughtfully into existing testing practices, accompanied by efficient pathways to formal diagnosis ...
Alex Viguerie, Chaitra Gopalappa, Cynthia M. Lyles, Paul G. Farnham   +3 more
doaj   +1 more source

Nicotinamide Metabolism Constrains Memory CD8+ T Cell Formation Through a Putative HS1BP3‐SIRT1‐FOXO3‐BCL6 Axis

Advanced Science, EarlyView.
ABSTRACT Memory T cells exhibit long‐term persistence, a defining feature that underpins durable clinical responses to adoptive immunotherapies. The mechanisms that integrate metabolic cues with transcriptional control of memory fate remain undetermined. Here, we identify HS1‐binding protein 3 (HS1BP3) is preferentially expressed in memory CD8+ T cells.
Siyang Wang, Xiaoqian Fan, Yifan Huang, Chang Yao, Jixing Fan, Yu Ping, Xuan Zhao, Congcong Li, Chunyi Shen, Jiqi Shan, Jinyan Liu, Shengdian Wang, Zhen Zhang, Yi Zhang   +13 more
wiley   +1 more source

The Nature of Cell‐Penetrating Poly(disulfide)s

Angewandte Chemie, EarlyView.
The mode of action of cell‐penetrating poly(disulfide)s (CPDs) is elucidated to understand thiol‐mediated uptake (TMU) in general and guide future efforts to control cellular entry for chemicals delivery and pathogen defense. ABSTRACT Cell‐penetrating poly(disulfide)s (CPDs) are the most popular thiol‐mediated uptake (TMU) tools for delivering attached
Saidbakhrom Saidjalolov, Giacomo Renno, Yuheng Zhang, Michael Cognet, Justin Neuman, Andreas Hennig, Naomi Sakai, Stefan Matile   +7 more
wiley   +2 more sources