Results 81 to 90 of about 7,403,959 (300)

Translational Barriers and AI‐Driven Challenges of Microfluidics‐Enabled Wearables and Implantable Systems in Personalized Medicine

Advanced Science, EarlyView.
An integrative review of microfluidics‐enabled wearables and implantable systems reveals a single‐track translation pipeline, bridging functional biomaterials with clinical utility. Dynamic feedback loops driven by artificial intelligence advance diagnostics toward personalized closed‐loop theranostics.
Ke Huang, Ching Yin Fong, Xin Huang, Bee Luan Khoo   +3 more
wiley   +1 more source

Distinct Cleavage Trajectories Mediated by DNA and RNA Substrate in Argonaute From Methanocaldococcus Fervens

Advanced Science, EarlyView.
This study characterizes MfAgo, an enzyme exhibiting highly efficient DNA‐guided DNA and RNA cleavage capability. Precise RNA cleavage strictly requires dimerization to stabilize the PIWI‐loop region, while its robust DNA cleavage functions in a dimerization‐independent manner.
Fuyong Huang, Taiyu Chen, Meng Fang, Qinmiao Duanmu, Kangle Mu, Yuqi Bi, Siwei Xu, Xin Tao, Jiening Wang, Shan Wu   +9 more
wiley   +1 more source

Comparison of practicability and effectiveness between unassisted HIV self-testing and directly assisted HIV self-testing in the Democratic Republic of the Congo: a randomized feasibility trial

BMC Infectious Diseases, 2020
Background HIV self-testing (HIVST) can be performed using directly assisted and unassisted approaches in facilities or communities to reach different populations.
Serge Tonen-Wolyec, Charles Kayembe Tshilumba, Salomon Batina-Agasa, Roland Marini Djang’eing’a, Marie-Pierre Hayette, Laurent Belec   +5 more
doaj   +1 more source

High accuracy of home-based community rapid HIV testing in rural Malawi. [PDF]

, 2010
OBJECTIVE: To assess the performance of rapid HIV antibody tests when used as part of a home-based community wide counseling and testing strategy in northern Malawi. DESIGN: A cross-sectional population survey of HIV infection, 2007 to 2008.
Richard Ndhlovu, Emmanuel Banda, Crampin, Amelia C., Molesworth, Anna M., Glynn, Judith R., Neil French, Jacqueline Saul, Glynn, Judith R, French, Neil, Ndhlovu, Richard, Banda, Emmanuel, Molesworth, Anna M, Crampin, Amelia C, Anna M Molesworth, Saul, Jacqueline, Judith R Glynn, Amelia C Crampin, Ngwira, Bagrey, Bagrey Ngwira   +18 more
core   +1 more source

Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets

Advanced Science, EarlyView.
An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Xinjie Lin, Yangchang Zhang, Yang Pu, Duanke Liu, Tao Lei, Kai Ma, Qiyu He, Zheng Dou, Yuze Liu, Dengyuan Liu, Yinge He, Yanshang Wang, Xiaojiao Zheng, Yanbing Ma, Jianrong Zhou, Weiding Zhai, Binbin Su, Li Chen, Shoujun Li   +18 more
wiley   +1 more source

Access to care in people living with HIV [PDF]

, 2012
Includes bibliographical references.South Africa has the most people living with HIV (PLWH) in the world. With increased access to HIV Counselling and Testing (HCT) as well as expanded Antiretroviral Therapy (ART) treatment guidelines; there is a large ...
Du Toit, Elizabeth
core   +1 more source

Community based distribution of oral HIV self-testing kits in Zambia: a cluster-randomised trial nested in four HPTN 071 (PopART) intervention communities [PDF]

, 2018
Background The HPTN 071 (PopART) cluster-randomised trial provided door-to-door HIV testing services to a large proportion of individuals residing in 21 intervention communities in Zambia and South Africa from 2014 to 2017 and reached the UNAIDS first ...
Kanema, Sarah, Cohen, Myron, El-Sadr, Wafaa, Sakala, Ephraim, James, Anelet, Bond, Virginia, Moore, Ayana, Makola, Nozizwe, Kumar, Ramya, Beyer, Nulda, Noble, Heather, van Deventer, Anneen, Sauter, Rafael, Wilson, Ethan, Dunbar, Rory, Mwinga, Alwyn, Silumesi, Andrew, Griffith, Sam, Headen, Tanette, Floyd, Sian, Emel, Lynda, Schaap, Albertus J, Miller, Eric, Bwalya, Chiti, Cori, Anne, Skalland, Tim, Hauck, Katharina, Thomas, Ranjeeta, Eshleman, Susan, Kosloff, Barry, Shanaube, Kwame, Mandla, Nomtha, Pickles, Michael, Yang, Blia, Ayles, Helen, Hargreaves, James, Vermund, Sten, Macleod, Dave, Burns, David, Jennings, Karen, Smith, Peter C, Donnell, Deborah, Probert, Will, Yuhas, Krista, Hayes, Richard, Mulubwa, Chama, Fraser, Christophe, Limbada, Mohammed, Bwalya, Justin, Bock, Peter, Hoddinott, Graeme, Phiri, Mwelwa M, Piwowar-Manning, Estelle, Sabapathy, Kalpana, Mwenge, Lawrence, Fidler, Sarah, Hensen, Bernadette, Kruger, James, White, Rhonda, Phiri, Comfort R, Sista, Niru, Simwinga, Musonda, Phiri, Mwelwa, Agyei, Yaw   +63 more
core   +1 more source

A General High‐Throughput Mucus Microrheology Platform for Quantitative and Scalable Mucus Phenotyping

Advanced Science, EarlyView.
High‐throughput Differential Dynamic Microscopy measures frequency‐resolved mechanical fingerprints from 3 to 10 μL$\umu{\rm L}$ mucus samples using only a few minutes of operator attention per sample. This automated analysis enables scalable mucus phenotyping for translational research by distinguishing mechanical heterogeneity among donors, disease ...
Feng Ling, Ayşe Tuğçe Şahin, Bernardo Miller Naranjo, Stefano Aime, Doris Roth, Anna Pukaluk, Niels Tepho, Romina Augustin, Benedetta Zampa, Andrea S. Vendrame, Mark‐Christian Klassen, Ellen Emken, Marion Kiechle, Mircea Gabriel Stoleriu, Pontus Mertsch, Ruth Olmer, Yohannes Tesfaigzi, Oliver Lieleg, Janna C. Nawroth   +18 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Overestimating HIV infection: [PDF]

In the absence of HIV testing, how do rural Malawians assess their HIV status? In this paper, we use a unique dataset that includes respondents’ HIV status as well as their subjective likelihood of HIV infection. These data show that many rural Malawians
Hans-Peter Kohler, Philip Anglewicz
core