Results 101 to 110 of about 3,269,718 (260)

Dual Blockade of LILRB1 and LILRB2 Enhances Antiviral Immune Responses in SIV Infection

Advanced Science, EarlyView.
Dual LILRB1/B2 blockade with mac20G10 reshapes myeloid activation during acute SIV infection by targeting LILRB1 and LILRB2 on myeloid cells. This treatment enhances CD80 expression on selected myeloid subsets and increases plasma IFN‐λ, IL‐8, and IL‐1RA.
Florian Meurisse, Sixtine Coindre, Anne Wijkhuisen, Romain Marlin, Laure Fournier Le Ray, Juliette Pons, Melyssa Yaugel‐Novoa, Véronique Avettand‐Fenoel, Laurent Abi‐Rached, Anne‐Sophie Gallouet, Francis Relouzat, Mael Gourves, Asier Saez‐Cirion, Hisashi Arase, Gerard Zurawski, Sandra Zurawski, Nathalie Dereuddre‐Bosquet, Roger Le Grand, Stéphanie Simon, Olivier Lambotte, Benoit Favier   +20 more
wiley   +1 more source

Preferences for HIV testing services among young people in Nigeria

BMC Health Services Research, 2019
Background Despite high HIV incidence rates among young people in Nigeria, less than 24% of this population have ever tested for HIV. These low HIV testing rates suggest that current testing services may not align with their testing preferences.
Ucheoma Nwaozuru, Juliet Iwelunmor, Jason J. Ong, Sawsan Salah, Chisom Obiezu-Umeh, Oliver Ezechi, Joseph D. Tucker   +6 more
doaj   +1 more source

Cost-effectiveness of voluntary HIV-1 counseling and testing in reducing sexual transmission of HIV-1 in Kenya and Tanzania. [PDF]

, 2000
Background Access to HIV-1 voluntary counseling and testing (VCT) is severely limited in less-developed countries. We undertook a multisite trial of HIV-1 VCT to assess its impact, cost, and cost-effectiveness in less-developed country settings.\ud ...
Sangiwa , G, Balmer, D, Sweat , M, Furlonge , C, Coates , T, Kamenga , C, Gregorich , S, Grinstead, O   +7 more
core  

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

Linkage to HIV care and antiretroviral therapy in Cape Town, South Africa. [PDF]

, 2010
BACKGROUND: Antiretroviral therapy (ART) has been scaled-up rapidly in Africa. Programme reports typically focus on loss to follow-up and mortality among patients receiving ART.
Zeinecker, Jennifer, Zeinecker Jennifer, Philip Ginsberg, Kalawe, Nosindiso N, Lawn, Stephen D, Robin Wood, Stephen D Lawn, Ginsberg Philip, Bekker Linda-Gail, Kranzer Katharina, Orrell, Catherine, Orrell Catherine, Lawn Stephen D., Nosindiso N. Kalawe, Ginsberg, Philip, Stephen D. Lawn, Katharina Kranzer, Nosindiso N Kalawe, Linda-Gail Bekker, Kalawe Nosindiso N., Wood Robin, Bekker, Linda-Gail, Kranzer, Katharina, Jennifer Zeinecker, Catherine Orrell, Wood, Robin   +25 more
core   +2 more sources

“He Told Me to Check My Health”: A Qualitative Exploration of Social Network Influence on Men’s HIV Testing Behavior and HIV Self-Testing Willingness in Tanzania

American Journal of Men's Health, 2018
Men continue to test for HIV at a low rate in sub-Saharan Africa. Recent quantitative evidence from sub-Saharan Africa indicates that encouragement to test for HIV from men’s network members is associated with higher previous HIV testing and HIV self ...
Donaldson F. Conserve, Dawit Alemu, Thespina Yamanis, Suzanne Maman, Lusajo Kajula   +4 more
doaj   +1 more source

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

Tuberculosis in HIV-negative and HIV-infected patients in a low-incidence country: clinical characteristics and treatment outcomes [PDF]

, 2012
BACKGROUND: In Switzerland and other developed countries, the number of tuberculosis (TB) cases has been decreasing for decades, but HIV-infected patients and migrants remain risk groups.
Thomas Bodmer, Gagneux, Sebastien, Bodmer, Thomas, Swiss HIV Cohort and Molecular Epidemiology of Tuberculosis Study Groups, Schrenzel, J., Bottger, E. C., Schrenzel Jacques, Jean-Paul Janssens (174301), Cavassini Matthias, Matthias Egger, Enos Bernasconi (174329), Jacques Schrenzel, Egger, M., Böttger Erik C., Schrenzel, Jacques, Matthias Egger (24558), Böttger, E.C., Jan Fehr (174310), Fehr Jan, Janssens, J. P., Bodmer Thomas, Bernasconi, E., Gagneux, S., Fenner, Lukas, Egger, Matthias, Enos Bernasconi, Egger Matthias, Hoffmann, Matthias, Erik C. Böttger (174343), Cavassini, M., Matthias Hoffmann, Jacques Schrenzel (22586), Janssens, J.P., Böttger, Erik C, Helbling, Peter, Matthias Cavassini (146654), Gagneux Sebastien, Fenner, L., Matthias Hoffmann (174320), Peter Helbling (174346), Helbling, P., Bernasconi, Enos, Jan Fehr, Erik C Böttger, Thomas Bodmer (174337), Lukas Fenner, Fenner Lukas, Fehr, Jan, for the Swiss HIV Cohort and Molecular Epidemiology of Tuberculo,, Janssens, Jean-Paul, Helbling Peter, Bernasconi Enos, Sebastien Gagneux (149824), Janssens Jean-Paul, Hoffmann, M., Hoffmann Matthias, Sebastien Gagneux, Peter Helbling, Lukas Fenner (149822), Jean-Paul Janssens, Fehr, J., Cavassini, Matthias, Bodmer, T., Matthias Cavassini   +63 more
core   +3 more sources

METTL7A Downregulation Drives SLC1A5‐Mediated Glutamine Competition to Promote Tumor Proliferation and Suppress CD8+ T Cell Immunity in Gastric Cancer

Advanced Science, EarlyView.
GC cells enhance glutamine accumulation by upregulating SLC1A5 expression. This upregulation not only boosts GC cell proliferation, but also outcompetes CD8+ T cells for glutamine and suppresses their antitumor immunity. Mechanistically, METTL7A deficiency in GC induces SLC1A5 overexpression via an m6A‐dependent pathway and N‐glycosylation ...
Mingjun Sun, Shuwei Dang, Dazhi Zhou, Lixian Ding, Xun Sun, Wei Suo, Jirui Niu, Qingzhu Yang, Zhicheng Zhang, Yanyan Sun, Jinxing Li, Zhongsheng Chen, Tao Ban, Yingji Wang, Tianzhu Li, Ming Liu, Guodong Li   +16 more
wiley   +1 more source

Stress Hyperglycemia Drives CD4+ T Cell PANoptosis and Postoperative Organ Injury via Monocyte‐Derived Succinate

Advanced Science, EarlyView.
High glucose is linked to reduced succinate dehydrogenase activity in CD14+ monocytes, accompanied by succinate accumulation and extracellular release. Extracellular succinate exacerbates mitochondrial ROS production and mtDNA release in CD4+ T cells. Cytosolic mtDNA then activates Z‐DNA binding protein 1 (ZBP1) and engages ZBP1‐associated inflammatory
Shuai Zhao, Xuemei Miao, Wei Luo, Tao Liu, Yang Wang, Jiaying Li, Di Fu, Weiyun Shen, Yan Luo, Kang Chen, Ruping Dai, Hui Li   +11 more
wiley   +1 more source