Results 101 to 110 of about 1,065 (135)
Some of the next articles are maybe not open access.
Clinical significance of Hiwi gene expression in gliomas
Brain Research, 2011Piwi, highly conserved during evolution, has been reported to play a key role in stem cell self-renewal in several different organisms. As one of the four human homologues of the Piwi family, Hiwi has been demonstrated to be significantly overexpressed in some human cancer. However, the relationship between Hiwi and human gliomas is unclear.
Yingyi Wang, Hui Luo, Yongping You
exaly +3 more sources
Expression of HIWI in Human Hepatocellular Carcinoma
Cell Biochemistry and Biophysics, 2011In this study, the investigation of the expression of HIWI and its protein in hepatocellular carcinoma (HCC) was performed, and the relationships between HIWI expression and the location of HCC metastases were analyzed. Sets of fresh HCC and matched adjacent normal hepatic tissue and paraffin-embedded tissue slides were provided by the hospital ...
Hongjie Zhang +2 more
exaly +3 more sources
Overexpression of Hiwi Promotes Growth of Human Breast Cancer Cells [PDF]
Asian Pacific Journal of Cancer Prevention, 2014 The Piwi subfamily comprises two argonaute (Ago) family proteins, which are defined by the presence of PAZ and Piwi domains, with well known roles in RNA silencing. Hiwi, a human Piwi subfamily member, has been shown to play essential roles in stem cell self-renewal and gametogenesis.
Zhao-Hui Wang
exaly +3 more sources
Silencing HIWI suppresses the growth, invasion and migration of glioma cells
International Journal of Oncology, 2014 The HIWI gene is one of the members of the PIWI gene family that is important for stem cell self‑renewal and expressed highly in certain human tumors. Some studies have demonstrated that HIWI plays a key role in the development of tumors in cervical, colon and liver cancer.
Hongmei Gao, Xiaoling Yan, Xinnv Xu
exaly +4 more sources
Hiwi facilitates chemoresistance as a cancer stem cell marker in cervical cancer
Oncology Reports, 2014 Hiwi, also named PiwiL1, is a human homologue of the Piwi family which is associated with stem cells and is overexpressed in several types of cancers. In the present study, we aimed to investigate the role of Hiwi in cervical carcinogenesis. Immunochemical analysis showed a significantly higher frequency of Hiwi staining in high-grade squamous ...
Kunlun Chen, Mu Li, Ya Gao
exaly +4 more sources
Hiwi Knockdown Inhibits the Growth of Lung Cancer in Nude Mice
Asian Pacific Journal of Cancer Prevention, 2013 Hiwi, a human homologue of the Piwi family, plays an important role in stem cell self-renewal and is overexpressed in various human tumors. This study aimed to determine whether an RNA interference-based strategy to suppress Hiwi expression could inhibit tumor growth in a xenograft mouse model.
Dong, Liang +6 more
exaly +4 more sources
Overexpression of Hiwi Inhibits the Growth and Migration of Chronic Myeloid Leukemia Cells
Cell Biochemistry and Biophysics, 2015Chronic myeloid leukemia (CML) is a hematopoietic malignancy characterized by dysregulated growth and proliferation of hematopoietic stem/progenitor cells in bone marrow and excessive expansion of hematopoietic compartments in peripheral blood. Expression deletion of Hiwi, a human Piwi homolog, has been reported to be implicated in leukemogenesis.
Cong Xiaofeng
exaly +3 more sources
Molecular characterization of hiwi, a human member of the piwi gene family whose overexpression is correlated to seminomas [PDF]
Oncogene, 2002 The piwi family genes are highly conserved during evolution and play essential roles in stem cell self-renewal, gametogenesis, and RNA interference in diverse organisms ranging from Drosophila melanogaster and C. elegans to Arabidopsis. Here we report the molecular characterization of hiwi, a human member of the piwi gene family.
Leendert H J Looijenga +2 more
exaly +4 more sources
Expression of HIWI in endometrial carcinoma tissues and its clinical significance [PDF]
European Journal of Gynaecological Oncology (discontinued), 2020 exaly +2 more sources
High adult mortality among Hiwi hunter-gatherers: Implications for human evolution
Journal of Human Evolution, 2007Extant apes experience early sexual maturity and short life spans relative to modern humans. Both of these traits and others are linked by life-history theory to mortality rates experienced at different ages by our hominin ancestors. However, currently there is a great deal of debate concerning hominin mortality profiles at different periods of ...
Kim Hill, A Magdalena Hurtado
exaly +3 more sources