Results 1 to 10 of about 318 (82)

Selective agonists of KIR and NKG2A to evade missing self response of natural killer cells [PDF]

Scientific Reports
Immune rejection is one of the most serious challenges in allogeneic transplantation, including allogeneic induced pluripotent stem cell (allo-iPSC)-derived cell therapy. Beta-2-Microglobulin gene-knockout, human leukocyte antigen (HLA) class I-deficient
Satoshi Hiura, Yuto Kuwasaki, Yosuke Nishikawa, Takako Kimura, Sayaka Yoshida, Makiko Nakayama, Tomohiro Makino, Suguru Ueno   +7 more
doaj   +2 more sources

Analysis of HLA-Ⅰ antibody specificity and estimation of antigen immunogenicity: 96 patients recieved genotype-matched platelet transfusions

Zhongguo shuxue zazhi, 2022
Objective To analyze the specificity of HLA class-Ⅰ antibody in the patients received HLA-matched platelet transfusions and estimate the relative immunogenicity of HLA-Ⅰ antigens.
Ying LIU, Xinyu HUANG, Bing ZHANG, Gang XU, Xianguo XU, Ji HE, Faming ZHU   +6 more
doaj   +1 more source

Factors affecting the efficacy of platelet transfusion and specificity of HLA-Ⅰ antibodies in tumor patients

Zhongguo shuxue zazhi, 2023
Objective To analyze the factors affecting the efficacy of platelet transfusion and the specificity of HLA-Ⅰ antibodies in tumor patients. Methods Tumer patients applied for platelet transfusion from November 2019 to July 2021 in Sichuan Cancer Hospital ...
Juan SAI, Shanshan WAN, Li TIAN
doaj   +1 more source

Causes of HLA-A2 reactive antibodies and analysis of their eplets

Zhongguo shuxue zazhi, 2023
Objective To analyze differences of eplets between the patient who generated HLA allele-specific antibodies after platelet transfusion with donors. Methods The HLA genotypes of the patient and donors were detected by PCR-SBT, and the Luminex single ...
Jingjing HUANG, Longhai TANG, Yuanling ZUO, Yan CAO, Weijie LI, Min JIANG, Mingyuan WANG   +6 more
doaj   +1 more source

Analysis of HLA allele-specific antibodies and Eplets in patients with platelet transfusion refractoriness

Zhongguo shuxue zazhi, 2022
Objective To analyze the specificity and Eplets of HLA allele-specific antibody in patients with platelet transfusion refractoriness (PTR). Methods HLA-A and B genotypes were detected by PCR-SBT, and HLA-Ⅰ antibodies in patients′ serum were detected by ...
Bing ZHANG, Xinyu HUANG, Ying LIU, Gang XU, Shu CHEN, Xianguo XU, Faming ZHU   +6 more
doaj   +1 more source

Platelet antibody of blood donors in Suzhou

Zhongguo shuxue zazhi, 2022
Objective To study the incidence and specificity of platelet antibody in blood donors in Suzhou, analyze the distribution characteristics of platelet antibody in blood donors in this area, and explore the significance of platelet antibody detection in ...
Li DONG, Ming FANG, Yujue WANG, Honghong HE, Hongmei WANG, Yezhou CHEN, Feiran Wu, Shengbao DUAN, Longhai TANG   +8 more
doaj   +1 more source

Correlation between the quantitative intensity of HLA-Ⅰ gene and its antibody and the clinical transfusion effect of matching platelets

Zhongguo shuxue zazhi, 2022
Objective To explore the influence of anti-HLA-Ⅰ with different mean fluorescence intensity (MFI) on the efficacy of HLA-A and -B gene matching platelet transfusion, so as to provide scientific data for clinical platelet gene matching transfusion ...
Xinyu HUANG, Shu CHEN, Ying LIU, Bing ZHANG, Ji HE, Xianguo XU, Faming ZHU   +6 more
doaj   +1 more source

Impact of HLA antigen and antibody expression on cross-matching and transfusion effect

Zhongguo shuxue zazhi
[Objective] To study the relationship between the expression intensity of HLA-Ⅰ platelet antibodies in patients with platelet transfusion refractoriness (PTR) and platelet cross-matching, and to further evaluate other factors in order to provide relevant
HE Honghong, CHENG Jing, WANG Yihan, JIANG Min, TANG Longhai   +4 more
doaj   +1 more source

Distribution of platelet antibodies and their specificity in Zhongshan area

Zhongguo shuxue zazhi
Objective To investigate the frequency of platelet antibodies in voluntary blood donors and patients in Zhongshan, Guangdong Province, and to study the specificity and cross-matching of platelet antibodies. Methods Platelet antibodies of blood donors and
Huiyan LIN, Yonglun WU, Ainong SUN, Yuru FANG, Qianying CHEN, Qiao LI, Yujue WANG, Hongmei WANG, Zhizhao YANG, Xiaoyi JIAN, Xianguo XU, Shengbao DUAN   +11 more
doaj   +1 more source

Antibody identification and analysis of 80 children with positive platelet antibody in initial screening

Zhongguo shuxue zazhi
Objective To explore the distribution and types of platelet antibodies in children with positive platelet antibody in initial screening. Methods Blood samples of 80 pediatric patients who applied for platelet transfusion in our hospital from September ...
Xiaohuan WANG, Xiaoyan FU, Yu LIU, Shuaihang ZHANG, Shuxuan MA   +4 more
doaj   +1 more source