Results 101 to 110 of about 548,741 (210)

Genetic modulation of antigen presentation by HLA-B27 molecules.

, 1992
In studies of antigenic peptide presentation, we have found a healthy volunteer whose lymphoblastoid cells were unable to present three different virus-derived epitopes to cytotoxic T lymphocytes (CTL) despite expressing the correct restricting HLA-B27 ...
A McMichael, L Pazmany, S Huet, A Hill, J Sutton, J Brooks, S Rowland-Jones, R Murray   +7 more
core   +1 more source

Characterization of the Recognition Specificity of BH2, a Monoclonal Antibody Prepared against the HLA-B27 Heavy Chain

, 2015
BH2, a monoclonal antibody prepared against the denatured human leukocytic antigen-B27 heavy chain (HLA-B27 HC), can immunoprecipitate the misfolded HLA-B27 HC complexed with Bip in the endoplasmic reticulum and recognize the homodimerized HLA-B27 HC ...
Hsien-Bin Huang, Ning-Sheng Lai, Hsien-Lu Huang, Wen-Chien Lee, Wei-Ting Liu, Hui-Chun Yu, Ming-Chi Lu, Su-Qin Liu, Kuang-Yung Huang   +8 more
core   +1 more source

HLA-B27-associated gut microbiota and amino acid perturbations promote ankylosing spondylitis through M1 macrophage activation

Gut Microbes
Ankylosing spondylitis (AS) is strongly associated with the human leukocyte antigen B27 (HLA-B27), yet how this genetic risk factor interacts with the gut microbiome remains unclear.
Tianwen Huang, Hang Yang, Lingshu Zhang, Xiangpeng Wang, Ye Chen, Huanzi Dai, Kenji Hashimoto, Yubin Luo, Yaoyu Pu, Yi Liu   +9 more
doaj   +1 more source

The rapid detection of human HLA-B*27 gene based on BASIC isothermal detection

Scientific Reports
Ankylosing spondylitis (AS) is a chronic, inflammatory arthritis of the spine and peripheral joints which is known to have a strong association with the human leukocyte antigen B27 (HLA-B27).
Ying Chen, Jianing Ren, Xin Yang, Zhanggang Li, Wenwen Wu, Guangcheng Luo, Yuan Xu, Hongjun Yang, Qiang Wang, Qing Zhang   +9 more
doaj   +1 more source

CD28 and CTLA4 polymorphisms associated with ankylosing spondylitis: a study in the context of HLA-B27

BMC Immunology
Background The human leukocyte antigen (HLA)-B27 gene is highly associated with ankylosing spondylitis (AS). However, not everyone who carries the HLA-B27 antigen develops AS, indicating that factors beyond the HLA-B27 gene contribute to the disease’s ...
Kuang-Hui Yu, Gem Huai-Chueh Wu, Chia-Ju Yang, Wei-Tzu Lin, Fang-Ping Hsu, Ding-Ping Chen   +5 more
doaj   +1 more source

聚合酶链反应-直接测序法在强直性脊柱炎患者HLA-B27检测中的应用

Zhongguo shiyan zhenduanxue, 2015
目的探讨聚合酶链反应-直接测序法(polymerase chain reaction sequence-based typing,PCR-SBT)检测人类白细胞抗原B27(human leukocyte antigen B27,HLA-B27)在强直性脊柱炎(ankylosing spondylitis,AS)临床诊断中的价值。方法应用PCR-SBT法和临床常用的IMS-ELISA法对120例疑似AS患者外周血进行HLA-B27检测。以SPSS17 ...
王平均, 孙灵迪, 梅传忠, 武晓茜, 邵先安   +4 more
doaj  

Editor’s Pick: Why Do Diseases Start One Sided? Clues from Hla-b27 Acute Anterior Uveitis

, 2017
Uveitis is an inflammatory disease with significant disease burden, as it causes ≤10% of legal blindness in the USA. Patients are usually affected in their prime working years.
Margo S. Clarke
core  

Impact of sex and HLA-B27 positivity on clinical characteristics and patient-reported outcomes in a cohort of Egyptian axial spondyloarthritis patients. [PDF]

BMC Musculoskelet Disord
Soliman E, Zeheiry M, Abu Halawa Y, Shaaban A.   +3 more
europepmc   +1 more source

Non-Radiographic Axial Spondyloarthritis Presenting with Anterior Chest Wall Pain without Inflammatory Back Pain in an HLA-B27-Negative Young Man: A Case Report Highlighting Diagnostic Challenges. [PDF]

Int Med Case Rep J
Gergeus R, Nasra AB, Barghouth R, Sheikh Ali D.   +3 more
europepmc   +1 more source

Anterior endogenous uveitis and HLA-B27 antigen

Oftalmologicheskii Zhurnal, 2010
G. Zhaboedov, N. Ivanova, A. Kopaenko
openaire   +1 more source