Results 161 to 170 of about 548,741 (210)
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Non-Antigen Presenting Effects of HLA-B27
Current Molecular Medicine, 2004Spondyloarthropathies (SpA) are a group of chronic rheumatic diseases, which show a strong asoociation with human leukocyte antigen (HLA)-B27. Although the association between HLA-B27 and the susceptibility to SpA was discovered thirty years ago, the exact mechanism by which HLA-B27 predisposes to disease development remains unclear. The classical role
Markus A, Penttinen +2 more
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1984
As in the previous Workshops, HLA-B27 appears to be one of the best defined antigens. Four sera are very good or excellent (Table 1) as, indicated by their quality scores based on the formula of Mickey and Terasaki. The few extra reactions of the above-mentioned sera are cross-reactions, mostly with B7.
B. S. Breur, P. Ivanyi
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As in the previous Workshops, HLA-B27 appears to be one of the best defined antigens. Four sera are very good or excellent (Table 1) as, indicated by their quality scores based on the formula of Mickey and Terasaki. The few extra reactions of the above-mentioned sera are cross-reactions, mostly with B7.
B. S. Breur, P. Ivanyi
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Biochemical Features of HLA-B27 and Antigen Processing
2009The strong association of the human MHC class I allele HLA-B27 with the development of the chronic inflammatory disease ankylosing spondylitis (AS) is clear and has been known for over three decades. Despite this, it is far from clear how HLA-B27 is directly involved in AS.
Simon J, Powis +2 more
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Typing of serum‐soluble HLA‐B27 antigen by ELISA
Tissue Antigens, 1993Abstract: An ELISA using serum as soluble HLA antigen source was developed for HLA‐B27 typing. Two sandwich assays were run in parallel. The first assay utilized a monoclonal antibody (mAb) reacting with a determinant expressed by both HLA‐B7 and B27 antigens; the other assay utilized a mAb reactive with HLA‐B7 antigens but not with HLA‐B27 antigens ...
P, Pouletty +9 more
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Novel HY peptide antigens presented by HLA-B27
The Journal of Immunology, 1997Abstract We have identified two peptides corresponding to the male-specific HY minor histocompatibility Ags presented by HLA-B27 in transgenic rodents, isolated from whole cell extracts and from immunoprecipitated B27 molecules of male B27 rat spleen cells.
Simmons, W A +13 more
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HLA-B27 AND DISEASE: A CONSEQUENCE OF INADVERTENT ANTIGEN PRESENTATION?
Rheumatic Disease Clinics of North America, 1992The close association of HLA-B27 with arthritic conditions has led to the suggestion that these diseases are mediated by cytotoxic T lymphocytes that recognize self-peptides presented by HLA-B27 molecules. The further association with enteric bacterial infections suggests that bacterial antigens may prime the CTL that later crossreacts on self ...
R, Benjamin, P, Parham
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Recognition of HLA-B27 and related antigen by a monoclonal antibody
Human Immunology, 1982A monoclonal antibody that binds specifically to HLA-B27, B7, and B22 is described. Binding to B27 appeared to be slightly stronger than to B7 and stronger than to B22 in an indirect binding assay, but no difference in B7 and B27 binding could be detected by Scatchard analysis.
S A, Ellis, C, Taylor, A, McMichael
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Luminal Bacterial Antigen-Specific CD4+ T-Cell Responses in HLA-B27 Transgenic Rats With Chronic Colitis Are Mediated by Both Major Histocompatibility Class II and HLA-B27 Molecules [PDF]
Immunology, 2006 Rats transgenic (TG) for the human major histocompatibility complex (MHC) class I HLA-B27 and β2-microglobulin genes develop chronic colitis under specific pathogen-free (SPF) but not sterile (germ-free, GF) conditions.
Ryan Balfour Sartor, Susan L Tonkonogy
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HLA B27 Antigens in Patients with Chronic Arthralgia
Scandinavian Journal of Rheumatology, 1989Role etiologique des arthrites reactionnelles dans les arthralgies chroniques. Recherche d'une frequence plus elevee de l'antigene HLA B27 chez 31 patients souffrant d'arthralgies chroniques de cause indeterminee et sans antecedents systemiques ni psychiatriques.
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[HLA-B27 antigen and alkaptonuria].
Revue du rhumatisme et des maladies osteo-articulaires, 1977Study of urinary homogentisic acid and a determinantion of group HLA were carried out for 36 members of a family spread over three generations with three cases of ochronotic rheumatism in the second generation. Alkaptonuria was discovered in seven other subjects, six of them members of the third generation: urinary elimination was poor, less than 0.60 ...
A, Gaucher +7 more
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