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Immunological Reviews, 1985
Despite major advances in genetic and structural studies of the HLA-B27 antigen, the underlying mechanism responsible for the remarkable association between this antigen and spondylarthropathies remains unknown. At a molecular level, the use of B27M1 and B27M2 monoclonal antibodies has permitted the identification of distinct allospecific epitopes on ...
P. Turek, F. Grumet, E. Engleman
semanticscholar +4 more sources
Despite major advances in genetic and structural studies of the HLA-B27 antigen, the underlying mechanism responsible for the remarkable association between this antigen and spondylarthropathies remains unknown. At a molecular level, the use of B27M1 and B27M2 monoclonal antibodies has permitted the identification of distinct allospecific epitopes on ...
P. Turek, F. Grumet, E. Engleman
semanticscholar +4 more sources
Recognition of HLA-B27 and related antigen by a monoclonal antibody.
Human Immunology, 1982A monoclonal antibody that binds specifically to HLA-B27, B7, and B22 is described. Binding to B27 appeared to be slightly stronger than to B7 and stronger than to B22 in an indirect binding assay, but no difference in B7 and B27 binding could be detected by Scatchard analysis.
S. Ellis, C. Taylor, A. McMichael
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Osteoarticular involvement of brucellosis and HLA-B27 antigen frequency in Turkish patients.
Diagnostic Microbiology and Infectious Disease, 2004The aim of the present study is to investigate a possible association between osteoarticular involvement of brucellosis and HLA-B27 antigen. Standard microtoxicity technique method was used for detection of HLA-B27 antigen in 78 patients with brucellosis and 100 healthy donors.
G. Ertem +4 more
semanticscholar +4 more sources
, 1984 As in the previous Workshops, HLA-B27 appears to be one of the best defined antigens. Four sera are very good or excellent (Table 1) as, indicated by their quality scores based on the formula of Mickey and Terasaki. The few extra reactions of the above-mentioned sera are cross-reactions, mostly with B7.
P. Ivanyi, B. S. Breur
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The Role of HLA-B27 in Argentinian Axial Spondyloarthritis Patients
Journal of clinical rheumatology, 2021Background The prevalence of human leukocyte antigen B27 (HLA-B27) is variable around the world. Our objectives were to estimate the frequency of HLA-B27 in an Argentinian cohort of axial spondyloarthritis (axSpA), to evaluate the differences between HLA-
Rodrigo García-Salinas +3 more
semanticscholar +1 more source
Biochemical analysis of variant HLA-B27 antigens
Human Immunology, 1983Biochemical analysis of HLA-B27 antigens from individuals that are HLA-ABC identical by serology but distinct in CML typing establishes that two types of HLA-B27 can be defined biochemically. The division of HLA-B27 into a W type and a K type by CML typing correlates perfectly with the biochemical data. HLA-B27 K type possesses a more basic isoelectric
Pavol Ivanyi +3 more
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Non-Antigen Presenting Effects of HLA-B27
Current Molecular Medicine, 2004Spondyloarthropathies (SpA) are a group of chronic rheumatic diseases, which show a strong asoociation with human leukocyte antigen (HLA)-B27. Although the association between HLA-B27 and the susceptibility to SpA was discovered thirty years ago, the exact mechanism by which HLA-B27 predisposes to disease development remains unclear. The classical role
Päivi Ekman +2 more
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HLA-B27 and antigen presentation: at the crossroads between immune defense and autoimmunity.
Molecular Immunology, 2014The HLA-B27 is historically studied as a susceptibility factor in spondyloarthropathies and, primarily, in ankylosing spondylitis (AS). Over the recent years however, it has been rediscovered as protective factor against some severe viral infections. This is due to the high capacity of virus-specific, HLA-B27-restricted CD8+ T cells for both intrinsic (
R. Sorrentino, R. Böckmann, M. Fiorillo
semanticscholar +5 more sources
HLA-B27 AND DISEASE: A CONSEQUENCE OF INADVERTENT ANTIGEN PRESENTATION?
Rheumatic Disease Clinics of North America, 1992The close association of HLA-B27 with arthritic conditions has led to the suggestion that these diseases are mediated by cytotoxic T lymphocytes that recognize self-peptides presented by HLA-B27 molecules. The further association with enteric bacterial infections suggests that bacterial antigens may prime the CTL that later crossreacts on self ...
Peter Parham, Richard J. Benjamin
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Biochemical Features of HLA-B27 and Antigen Processing
2009The strong association of the human MHC class I allele HLA-B27 with the development of the chronic inflammatory disease ankylosing spondylitis (AS) is clear and has been known for over three decades. Despite this, it is far from clear how HLA-B27 is directly involved in AS.
Susana G. Santos +2 more
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