Results 221 to 230 of about 375,043 (313)

AlphaFold and Docking Approaches for Antibody–Antigen and Other Targets: Insights From CAPRI Rounds 47–55

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Accurate modeling of the structures of protein–protein complexes and other biomolecular interactions represents a longstanding and important challenge for computational biology. The Critical Assessment of PRedicted Interactions (CAPRI) experiment has served for over two decades as a key means to assess and compare current approaches and ...
Ragul Gowthaman, Minjae Park, Rui Yin, Johnathan D. Guest, Brian G. Pierce   +4 more
wiley   +1 more source

HLA Class II Protein Expression Regulation Is Strongly Linked to Cis-Acting SNPs. [PDF]

HLA
Vince N, Ramsuran V, Viard M, Martinson J, Wolinsky S, Hussain S, Seaberg EC, Brown TT, Spence N, Thio CL, Goedert JJ, Hoots WK, Kirk GD, Carrington M.   +13 more
europepmc   +1 more source

Biomolecular Interaction Prediction in the Pre‐ and Post‐AlphaFold Era: The 8th CAPRI Evaluation

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT We report on the 8th CAPRI Evaluation period, capturing the assessment of CAPRI Rounds 47 to 55 (excluding the CASP and COVID‐related Rounds), which have witnessed the transition to AI‐driven prediction tools such as AlphaFold and related alternatives. The prediction Rounds in this evaluation are characterized by a high level of difficulty due
Marc F. Lensink, Nessim Raouraoua, Guillaume Brysbaert, Sameer Velankar, Shoshana J. Wodak, Alexandre M. J. J. Bonvin   +5 more
wiley   +1 more source

Next-generation neoantigen mRNA vaccines: Immuno-engineering strategies for precision cancer immunotherapy. [PDF]

Cell Oncol (Dordr)
Li X, Jabbarzadeh Kaboli P, Roozitalab G, Salahi S, Qian H, Zhang X, Chen K, Imani S.   +7 more
europepmc   +1 more source

Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy

Phytotherapy Research, EarlyView.
Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee, Yu Jin So, Il‐Joo Jo, Ji Yong Jang, Tae Han Yook, Jun Ho Lee, Sung Wook Kim, Kangwook Lee, Soo Jung Park, Gabsik Yang   +9 more
wiley   +1 more source

Discovery of tumor antigens in renal cell carcinoma and prospects for clinical application. [PDF]

Front Immunol
Kagirova E, Enikeeva K, Mukhamadeev R, Asadullina D, Sharifyanova Y, Shmelkova P, Gainullina D, Trifonova D, Gattinger P, Docena G, Dubovets A, Tulaeva I, Karaulov A, Valenta R, Pavlov V.   +14 more
europepmc   +1 more source

Mesenchymal stromal cell therapy for rheumatoid arthritis: Long‐term efficacy, safety, and mechanistic insights

Rheumatology &Autoimmunity, EarlyView.
Graphical abstract summarizing the multifactorial pathogenesis of rheumatoid arthritis (RA) and the therapeutic potential of mesenchymal stromal cell (MSC) therapy. MSCs provide promising benefits through their immunomodulatory properties, low immunogenicity, ability to promote tissue repair, and multi‐lineage differentiation, presenting a potential ...
Yingjia Chen, Ruiyu Gao, Xing Guo, Genhong Yao, Xiaojun Tang, Yile E. Liu, Lingyun Sun   +6 more
wiley   +1 more source

Antigen-presenting neutrophils link streptococcal infection to adaptive immune activation in guttate psoriasis. [PDF]

EBioMedicine
Das A, Hwang TL.
europepmc   +1 more source

Tumor antigen only (TAO) vaccine platforms for glioblastoma therapeutics: a systematic review of evidence from clinical trials. [PDF]

EClinicalMedicine
Chen HC, Wong ET, Sarangi S, Elinzano H, Kuburich NA, Mani SA, Ali R, Cielo D, Svokos KA, Sampath P, Malik AN, Lee CK, Doberstein CE, Lawler SE, Seyhan A, El-Deiry WS, Chen CC.   +16 more
europepmc   +1 more source

Novel Progress in Limbal Stem Cell Transplantation

Organ Medicine, EarlyView.
Liqin Huang, Liangbo Chen
wiley   +1 more source