Results 201 to 210 of about 282,112 (262)

In Utero HSC Transplantation for Sickle Cell Disease: A Potential Therapeutic Approach That Overcomes Complications of Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide but has limited treatment options, most of which carry significant side effects. At present, the only curative treatment for SCD is allogeneic or gene‐modified autologous hematopoietic stem cell (HSC) transplantation (Tx).
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

Sickle Cell Disease: Historical Overview and Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide, yet the limited treatment options currently available do not always adequately control the disease and carry significant side effects. At present, the only curative treatment is hematopoietic stem cell (HSC) transplantation, a procedure that carries considerable challenges and numerous ...
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

Preimplantation HLA Typing [PDF]

, 2006
openaire   +1 more source

Fetal Cells in Maternal Blood for Noninvasive Prenatal Testing—Is it Still a Distant Star?

Prenatal Diagnosis, EarlyView.
ABSTRACT Accurate and safe prenatal diagnosis of severe genetic disorders remains challenging despite advances in genomic technologies and increased use of cell‐free noninvasive prenatal testing (cfNIPT). Currently, approximately half of pathogenic copy number variants (pCNVs) and most monogenic disorders are identified only postnatally.
Ripudaman Singh, Katarina Ravn, Line Dahl Jeppesen, Maria Bach Laursen, Maibritt Nøgaard Lauridsen, Mathias Kølvraa, Marlene Christina Nielsen, Bolette Hestbek Nicolaisen, Inga Baach Cristensen, Morten Muhlig Nielsen, Britt Kidmose Ardal, Lars Henning Pedersen, Mads Tang Dalsgaard, Ida Vogel, Lotte Hatt   +14 more
wiley   +1 more source

Long‐term outcomes of haploidentical hematopoietic stem cell transplantation with antithymocyte globulin–based myeloablative conditioning in pediatric refractory or relapsed non‐Hodgkin lymphoma

Pediatric Investigation, EarlyView.
Single‐center retrospective data showed that ATG‐based myeloablative haploidentical hematopoietic stem cell transplantation provides durable remission and favorable long‐term survival in children with refractory/relapsed non‐Hodgkin lymphoma, achieving high engraftment rates, low relapse incidence, and acceptable toxicity.
Chenguang Jia, Jie Zheng, Meng Yuan, Hongbo He, Yibo Fan, Bin Wang, Guanghua Zhu, Jun Yang, Yanhui Luo, Lixiao Cai, Pan Zhang, Yanlong Duan, Maoquan Qin   +12 more
wiley   +1 more source

HLA Typing by Double ARMS

Lancet, The, 1991
Roger Chapman, J I Bell, W Z Mehal
exaly   +3 more sources

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HLA Typing in Multiple Sclerosis.

Lancet, The, 1982
A Compston
exaly   +3 more sources

Serum HLA Typing

Tissue Antigens, 1981
This paper establishes that HLA antigens can be detected in serum by lymphocytotoxicity inhibition. A score system is described which enables the degree of cytotoxicity inhibition to be quantitated. The following HLA antigens have been detected: A1, A2, A3, A11, Aw24, B5, B7, B8, B27, Bw35 and B40. It has not been possible to detect HLA‐B12.
B D, Tait, R I, Finlay, M J, Simons
openaire   +2 more sources

HLA Typing and Retinitis pigmentosa

Ophthalmologica, 2010
Retinitis pigmentosa is a disease whose pathogenesis remains largely obscure. A lot of evidences support the hypothesis that autoimmunity is involved, but no HLA antigen has ever been associated with retinitis pigmentosa. Ten patients with autosomal recessive retinitis pigmentosa were tissue typed for class I and II HLA antigens.
CASTAGNA, Irene Concetta, FAMA F, PETTINATO G, PALAMARA F, TROMBETTA, Costantino   +4 more
openaire   +2 more sources

HLA Typing in Birdshot Chorioretinopathy

American Journal of Ophthalmology, 1988
We examined 49 patients with birdshot chorioretinopathy in whom HLA typing had been performed. Of these 49 patients, 47 (95.9%) had the HLA-A29 antigen. The HLA-B12 (B44) antigen was also significantly associated with the disease, but this antigen is known to be in linkage disequilibrium with the antigen HLA-A29. The HLA-A2 antigen was less frequent in
H A, Priem, A, Kijlstra, L, Noens, G S, Baarsma, J J, De Laey, J A, Oosterhuis   +5 more
openaire   +2 more sources