Results 161 to 170 of about 253,374 (269)

Synthetic Strategies for Activity‐Based Probes to Decode Ubiquitin‐Like Modifiers

Chemistry – A European Journal, EarlyView.
ABSTRACT Ubiquitin‐like proteins (Ubls) such as SUMO, NEDD8, ISG15, URM1, UFM1, FAT10, ATG8/ATG12, and FUBI are essential regulators of cellular homeostasis, controlling processes from protein stability and trafficking to immune signaling and autophagy.
Saibal Chanda, Alan Pham, SreeNidhi Karnati, Natalia Soto Rodriguez, Alyssa Toner, Wenshe Ray Liu   +5 more
wiley   +1 more source

Machine learning-based model for prediction of carbamazepine- and allopurinol-induced severe cutaneous adverse reactions in Vietnamese. [PDF]

World Allergy Organ J
Nguyen NT, Tran MH, Vu HQ, Duong VC, Nguyen TMN, Hoang OT, Mai VNA, Can TT, Do NQ, Le Thi Minh H, Nguyen NN, Vu Thi H, Vu MT, Nguyen AQ, Pham YTH, Nguyen KV, Le L, van Nunen S, Craig TJ, Chu HC, Vo NS, Nguyen DV.   +21 more
europepmc   +1 more source

Operationalizing Precision Medicine in Drug Development: Predictive Biomarkers, Companion Diagnostics, and Regulatory Pathways

Clinical Pharmacology &Therapeutics, EarlyView.
Precision medicine offers the opportunity to improve the benefit–risk profile of new therapies by prospectively identifying patients most likely to respond or least likely to experience harm; however, its systematic integration into drug development remains inconsistent outside oncology.
Ingrid Holst‐Laubjerg, José M.A. Moreira   +1 more
wiley   +1 more source

Structural Modulation and Binding of HLA-DQ8 by Cysteine-to-Serine Mutated Insulin Peptide: Insights from Molecular Dynamics Simulations. [PDF]

Int J Mol Sci
Mittal R, Karki U, Lemos JRN, Chapagain P, Hirani K.   +4 more
europepmc   +1 more source

CytoScan: Automated Detection of Technical Anomalies for Cytometry Quality Control

Cytometry Part A, EarlyView.
ABSTRACT Studies evaluating cellular phenotypes by cytometry techniques are increasingly facing analytical challenges due to the multitudes of samples and parameters that are evaluated concurrently. Spurious technical effects resulting from a lack of standardization can affect marker distributions and further complicate multi‐sample analyses.
Tim R. Mocking, Felix Zwolle, Yejin Park, Angèle Kelder, Yvan Saeys, Jacqueline Cloos, Sofie van Gassen, Costa Bachas   +7 more
wiley   +1 more source

Association between HLA-DRB1*04:05 and the efficacy of immune checkpoint inhibitors for patients with advanced cancer. [PDF]

Front Endocrinol (Lausanne)
Watanabe M, Eguchi J, Takamoto A, Wada J.   +3 more
europepmc   +1 more source

Health economic considerations for pharmacogenomic services in the United Kingdom: The Centre for Excellence in Regulatory Science and Innovation in Pharmacogenomics

British Journal of Clinical Pharmacology, EarlyView.
Dyfrig A. Hughes, Henry Fong, Grace Hampson, Catrin O. Plumpton, Chris Sampson   +4 more
wiley   +1 more source

Flow cytometry‐based monitoring of chimeric antigen receptor (CAR) T cells: Reagent selection, assay design, and clinical utility

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Accurate quantification of chimeric antigen receptor (CAR) T cells is essential for monitoring post‐infusion CART expansion and persistence and for real‐time clinical decision‐making. Multiparameter flow cytometry (MFC) enables rapid, live‐cell detection with absolute quantification and concurrent immunophenotypic characterization. This review
Jianhua Ling, Wei Wang, Sa A. Wang
wiley   +1 more source

Recent updates in human leukocyte antigen B27-associated uveitis. [PDF]

Indian J Ophthalmol
Narain S, Gupta P, Pyare R, Shroff D, Rath PD.   +4 more
europepmc   +1 more source