Results 141 to 150 of about 253,374 (269)

Integrative multi-omics reveals that downregulation of HLA-DPA1/DPB1 drives macrophage immune-metabolic dysregulation in pediatric asthma. [PDF]

Front Immunol
Wen Y, Du Z, Zhong Z, Yuan Q, Lin L, Yao R, He J, Huang Q, Li L, Ouyang C, Huang J, Liu S, Chen C.   +12 more
europepmc   +1 more source

Clinical Images: Bone Buds as Precursors to Ankylosis in Axial Spondyloarthritis

Arthritis &Rheumatology, EarlyView.
Lilach Shkolnik Arad, Gleb Slobodin
wiley   +1 more source

Speckle Observations With PISCO in Calern (France): III. Astrometric Measurements of Visual Double Stars in 2019 and New or Revised Orbits for STT531 AB, STT77 AB, STF1338 AB, COU1746, STT260, A1109 AB, HU1291, and A632 AB

Astronomische Nachrichten, EarlyView.
ABSTRACT We present relative astrometric measurements of visual double stars, made in 2019 with the speckle camera PISCO at the 1‐m Epsilon telescope of the C2PU facility (Observatoire de la Côte d'Azur, Calern site). Our observing list contains orbital couples as well as double stars whose motion is still uncertain.
J.‐L. Prieur, M. Scardia, J.‐P. Rivet, E. Aristidi, J. F. Ling, L. Piccotti, L. Pansecchi, R. W. Argyle, L. Abe, P. Bendjoya, L. Maccarini, D. Vernet   +11 more
wiley   +1 more source

HLA alleles shape distinct biases in the usage preferences of TCR V<i>β</i> segments. [PDF]

Front Immunol
Castorina LV, Noakes MT, Pisani L, Greissl J, Robins H, Chen-Harris H, Zahid HJ.   +6 more
europepmc   +1 more source

Immunoinformatics‐Based Design of a Multi‐Epitope Vaccine Targeting a Conserved Copper–Associated Protein in Neisseria gonorrhoeae

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Neisseria gonorrhoeae poses an urgent public health challenge due to rapidly increasing antimicrobial resistance and the absence of an effective vaccine. Targeting conserved bacterial pathways involved in essential physiological processes may provide new opportunities for vaccine antigen discovery.
Sinethemba H. Yakobi, Uchechukwu U. Nwodo   +1 more
wiley   +1 more source

Targeting Amastigote and Trypomastigote Phases: Multi‐Epitope Vaccine Strategy Against Trypanosoma cruzi

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Effective vaccines against Trypanosoma cruzi, the causative agent of Chagas disease, are urgently needed. Here, we report the design and in silico validation of a novel multiepitope vaccine construct targeting the key surface proteins ASP‐2 and gp82. Using a comprehensive immunoinformatics pipeline, we identified and selected 38 potent T‐cell (
Maria Karolaynne da Silva, Caio Patrício de Souza Sena, Davi Serradella Vieira, Magdi E. A. Zaki, Leow Chiuan Yee, Shahina Akter, Umberto Laino Fulco, Jonas Ivan Nobre Oliveira, João Firmino Rodrigues‐Neto   +8 more
wiley   +1 more source

HLA-E single-chain trimer shields gene-edited allogeneic CAR T cells from NK cell attack. [PDF]

Blood Adv
Apodaca KM, Xu C, Stanton KL, Baroja ML, Alfaro Doblado AR, Engel NW, Wellhausen N, Cox A, Berjis A, Ji M, Bushara O, Perez DM, Welch C, Banerjee E, Assenmacher CA, Sheppard NC, Scholler J, June CH, Carreno BM, Linette GP.   +19 more
europepmc   +1 more source

Non-HLA Autoantibodies Associate With a Positive Flow-Crossmatch Pre- and Chronic Lung Allograft Dysfunction Post- Lung Transplant. [PDF]

HLA
Hiho S, Paporakis A, Rahman S, Levvey B, Diviney M, Snell G, Sullivan L, Westall G.   +7 more
europepmc   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

HLA Alleles and Haplotype Distribution Across Russian Population Groups. [PDF]

Int J Mol Sci
Kucherenko V, Doroschuk N, Sarygina E, Sagaydak O, Bogdanov V, Mityaeva O, Krupinova J, Woroncow M, Albert E, Volchkov P.   +9 more
europepmc   +1 more source