Results 131 to 140 of about 253,374 (269)

Clinical Images: Skeletal fluorosis presenting with diffuse periostitis and polyarticular synovitis

Arthritis &Rheumatology, EarlyView.
Mitali Sen
wiley   +1 more source

The Role of IgM Anti‐acetylated Protein Antibodies and B Cells in the Origin of Antimodified Protein Autoimmunity in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Rheumatoid arthritis (RA) is characterized by anti‐modified protein antibodies (AMPAs), including anti‐citrullinated protein antibodies (ACPA), anti‐carbamylated protein antibodies (anti‐CarP), and anti‐acetylated protein antibodies (AAPA). In contrast to other AMPAs, AAPA IgM is found in healthy individuals, raising questions about its role ...
Aegli Athanasiadou, Sanne Kroos, Renee van de Wetering, Rian Schopmeijer, Carin van der Keur, Michael Eikmans, Caroline Meijer, Solbritt Rantapää‐Dahlqvist, René E. M. Toes, Linda M. Slot, Diane van der Woude   +10 more
wiley   +1 more source

Last Licensed Non-Classical Peptide Presenter HLA-F: Its Occurrence, Immunoediting Significance, and Possible Therapeutic Implications in Renal Cell Carcinoma. [PDF]

Int J Mol Sci
Janků L, Fedorko M, Kašík M, Macháčková T, Křen L.   +4 more
europepmc   +1 more source

Increased Plasma Microbial tDR‐1 in At‐Risk Individuals Is Associated With Decreased Conversion to Clinical Rheumatoid Arthritis and Reduces an In Vitro Macrophage Type 1 Interferon Response

Arthritis &Rheumatology, EarlyView.
Objective Microbial small RNAs can regulate human genes. Higher plasma concentrations of microbial transfer RNA (tRNA)‐derived RNA‐1 (tDR‐1) were previously associated with lower rheumatoid arthritis (RA) disease activity. This study examined whether tDR‐1 concentrations differ in anticyclic citrullinated peptide‐3 positive (CCP3+) at‐risk individuals (
Anastasiia Phothisane, Tulsi K. Joishy, Carolina Ramirez‐Becerra, Qiong Wu, Jennifer Seifert, Marie L. Feser, Jill M. Norris, M. Kristen Demoruelle, LauraKay Moss, Kevin D. Deane, V. Michael Holers, Michelle J. Ormseth   +11 more
wiley   +1 more source

Ready-to-load MHC-I nanoparticles for high-throughput T cell screening studies. [PDF]

Sci Adv
Phan HAT, Eom S, Hwang D, Young MC, Sun SM, Erdman MC, Sun Y, Mallik L, Rotsides P, Painter MM, Wherry EJ, Monos DS, Sgourakis NG.   +12 more
europepmc   +1 more source

Dnmt3a Mutations Limit Normal and Autoreactive CD4+ T Follicular Helper Responses and Attenuate T Cell–Driven Joint Inflammation

Arthritis &Rheumatology, EarlyView.
Objective Somatic DNMT3A mutations are the most common drivers of clonal hematopoiesis in patients with rheumatoid arthritis (RA) and have been associated with seropositive disease and increased markers of inflammation. These mutations are predominantly hypomorphic or dominant‐negative, reducing DNMT3A function.
Yunbing Shen, Sanjaykumar Boddul, Zhaojun Li, Zsolt Kasza, Marlene Schülein, Bruno Raposo, Karine Chemin, Per‐Johan Jakobsson, Alexander Espinosa, Lars Klareskog, Fredrik Wermeling   +10 more
wiley   +1 more source

Coxsackievirus B escapes antiviral CD8⁺ T cells but triggers robust CD4⁺ memory responses. [PDF]

Sci Adv
Burgos-Morales O, Vecchio F, Samassa F, Petit M, Zhou Z, Brandao B, Carré A, Nicastri A, Dotsenko V, Shepherd C, Viiri K, Parker R, Linnemann AK, You S, Flodstrom-Tullberg M, Ternette N, Mallone R.   +16 more
europepmc   +1 more source

Deep Immunophenotyping Reveals Distinct Immune Signatures in Axial Spondyloarthritis and Psoriatic Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) are overlapping yet distinct conditions within the SpA spectrum. As divergent immunophenotypes may influence disease course and therapeutic response, we compared immune cell subsets, cytokine profiles, and inflammatory mediators.
Natalie Frede, Nils Craig‐Müller, Silke Kohrt, Marei‐Theresa Bott, Ulrich Salzer, Ana Cecilia Venhoff, Jens Thiel, Julia Frede, Reinhard E. Voll, Marta Rizzi, Raquel Lorenzetti, Nils Venhoff   +11 more
wiley   +1 more source

HLA-B*44 Alleles and HLA-DQA1*03:01 as Genetic Risk Factors for Drug-Induced Liver Injury due to Fluoroquinolones. [PDF]

Liver Int
Nicoletti P, Lucena MI, Andrade RJ, Zafer S, Bjornsson ES, Hallberg P, Larrey D, Molokhia M, Wadelius M, Aithal GP, Daly AK.   +10 more
europepmc   +1 more source

The performance of ChatGPT and other large language models on multiple‐choice questions in biomedical disciplines: A meta‐analysis

Anatomical Sciences Education, EarlyView.
Abstract While large language models (LLMs) have shown promise as learning tools for medical education, their reported accuracy on multiple‐choice questions (MCQs) varies widely across studies, necessitating synthesis. This meta‐analysis synthesizes LLM accuracy on text‐based MCQs from biomedical disciplines and USMLE Step 1‐level content and explores ...
Colleen M. Cheverko, Volodymyr Mavrych, Olena Bolgova, Fathima Raahima Riyas Mohamed, Jennifer Westrick, Lorena Juarez, Emily Rush, Kathryn A. Solka, Alison F. Doubleday, Jessica N. Byram, Robert Becker, Victoria Gomez, Brenda K. Anak Ganeng, Leslie A. Hoffman, Victoria A. Roach, Kirsten M. Brown, Nicole DeVaul, Colleen N. Garnett, Hannah L. Herriott, Rebecca S. Lufler, Jason C. Mussell, Joy Y. Balta, Michael A. Pascoe, Jason W. Middleton, Sharon Duffy, Georgina C. Stephens, Adam B. Wilson   +26 more
wiley   +1 more source