Results 121 to 130 of about 253,374 (269)

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Allogeneic Stem Cell Transplantation in Patients With Mixed Chimerism Following Double Cord Blood Transplantation: A Case Report. [PDF]

Case Rep Hematol
Park Y, Lee S, Kim J, Kim JA.
europepmc   +1 more source

T Cell Plasticity in Systemic Lupus Erythematosus Revealed by Large‐Scale T Cell Receptor Repertoire and Transcriptome Studies

Arthritis &Rheumatology, EarlyView.
Objective We aimed to characterize CD4+ T cell plasticity in human systemic lupus erythematosus (SLE) by leveraging T cell receptor (TCR) repertoire features as markers of prior lineage states, integrating TCR and transcriptomic profiling to delineate plasticity patterns and evaluate their association with clinical disease activity. Methods We used TCR
Yasuo Nagafuchi, Masahiro Nakano, Kaitlyn A. Lagattuta, Mineto Ota, Hiroaki Hatano, Haruka Takahashi, Takahiro Itamiya, Hajime Inokuchi, Soumya Raychaudhuri, Tomohisa Okamura, Keishi Fujio, Kazuyoshi Ishigaki   +11 more
wiley   +1 more source

Characterisation of the Novel HLA-DPB1*1810:01 Allele by Short-Read Next Generation Sequencing. [PDF]

HLA
Ryan O, Hickey C, Brennan E, Donghaile DÓ, Graham B.   +4 more
europepmc   +1 more source

T cells, the Next Big Target in Axial Spondyloarthritis?

Arthritis &Rheumatology, EarlyView.
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by complex immune dysregulation, with T cells playing a central role in its pathogenesis. In this review, we synthesize current knowledge on diverse T cell subsets in axSpA, their pathogenic mechanisms, and emerging therapeutic strategies targeting these cells. We highlight
Mansi K. Aparnathi, Nigil Haroon
wiley   +1 more source

Specific HLA-DRB1 Alleles Associate With Anti-Caspr1 and Anti-CNTN1 Autoantibodies in Autoimmune Nodopathies. [PDF]

Neurol Neuroimmunol Neuroinflamm
Lleixà C, Pascual-Goñi E, Martín-Aguilar L, Caballero-Ávila M, Collet-Vidiella R, Tejada-Illa C, Llarch P, Gallardo E, Boera-Carnicero G, Calahorro V, Callegari I, Cortese A, Delmont E, Devaux J, Giannotta CC, Nobile-Orazio E, Höftberger R, Sellner J, Herdewyn SAAJ, Alejandra C, Torné L, Jericó I, Rinaldi S, Sommer C, Doppler K, Armangue T, Titulaer MJ, Jacobs BC, Huizinga R, Wanschitz JV, Ortiz Castellon N, Sparasci D, Ripellino P, Pérez-Pérez H, Horga A, Alonso-Jiménez A, De Winter J, Jauregui A, de la Calle-Martin O, Martinez-Martinez L, Querol L.   +40 more
europepmc   +1 more source

Autoreactivity Versus Autoimmunity: Characteristics of Autoantigen‐Specific CD4 T Cells in Rheumatoid Arthritis and Health

Arthritis &Rheumatology, EarlyView.
Objective CD4 T cells specific for citrullinated (cit) peptides are key players in rheumatoid arthritis (RA) immunopathogenesis. Characterizing these cells and identifying features of healthy and RA‐associated autoreactivity will provide valuable insight into disease mechanisms and form the basis of immune state biomarkers to facilitate the next ...
James A. Stanway, Daniel Peters, Helen Waller, Jeremy Lakey, Henrique De Paula Lemos, Kristian Williams, Abbie Degnan, Julie Diboll, Abdul Mannan Baru, David Tough, Arthur G. Pratt, Catharien M.U. Hilkens, Amy E. Anderson, John D. Isaacs   +13 more
wiley   +1 more source

Targeting non-canonical antigens unlocks functional T-cell responses in renal cell carcinoma. [PDF]

J Immunother Cancer
Wang J, Zhu Y, He X, Yin S, He Y, Yao P, Li J, Li X, Shi P, Qian R, Xiao Z, Ye X, Xi JJ, Ye B.   +13 more
europepmc   +1 more source

Homocitrullinated Peptides Drive Pro‐Inflammatory T Cell Responses in a Humanized Mouse Model of Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Anti‐homocitrullinated protein/peptide antibodies are specific to rheumatoid arthritis (RA) and predictive of worse prognosis, suggesting a pathogenic role for autoreactivity to homocitrullinated peptides (HomoCitP). However, T cell responses to HomoCitP remain largely unexplored.
Sofya Ulanova, Jaspreet Kaur, Gabrielle Buckley, S. M. Mansour Haeryfar, Lisa Cameron, Ewa Cairns, Lillian Barra   +6 more
wiley   +1 more source

Human leukocyte antigen pharmacogenetics in infectious diseases: anti-infective drug toxicity and host immune response. [PDF]

Front Pharmacol
Negrini S, Nicola S, Badiu I, Quinternetto A, Vitali I, Lo Sardo L, Brussino L.   +6 more
europepmc   +1 more source