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Association of HLA‐DRBr with HLA‐DQw3
Tissue Antigens, 1988The antigen HLA‐DRBr, previously associated with HLA‐DQw1, has been found by RFLP to be associated with HLA‐DQw3.
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The FASEB Journal, 2020Epigenetic modifiers, such as the DNA methylation inhibitor 5‐Azacytidine (5‐AzaC), have been shown to increase human leukocyte antigen (HLA) expression. The expression of HLA is required for a T‐cell response to detect tumor cells. A lack of HLA expression allows tumor cells to escape immune detection.
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Abstract: Nine novel HLA‐A and HLA‐B alleles are described: A*2609, A*6803, A*6806, B*1539, B*1540, B*2712, B*4103, B*5109, and B*5603. Most appear to have arisen by gene conversion events. B*5603 appears to have arisen by a reciprocal recombination event joining exon 2 of a B*55/*56 allele with exon 3 of a B*15 allele.
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