Hma - Open Access .click

Results 101 to 110 of about 54,581 (294)

De novo TANC2 stop‐loss variant associated with developmental impairment and drug‐resistant epilepsy

Epileptic Disorders, EarlyView.
Matthew A. Hintermayer, Kenneth A. Myers
wiley +1 more source

Genome‐Wide Assessment Reveals Ancestral Differences in Homozygosity Patterns Potentially Linked to Parkinson's Disease Etiology

Movement Disorders, EarlyView.
Abstract Background Recessive genetic variation and extended runs of homozygosity (ROHs) may contribute to the unexplained heritability of Parkinson's disease (PD), particularly in diverse and understudied populations. Objective We conducted the first large‐scale, multi‐ancestral investigation of PD to examine the impact of genome‐wide homozygosity on ...
Kathryn Step +680 more
wiley +1 more source

27-Hydroxymangiferolic Acid Extends Lifespan and Improves Neurodegeneration in Caenorhabditis elegans by Activating Nuclear Receptors

Molecules
27-Hydroxymangiferolic acid (27-HMA) is a naturally occurring compound in mango fruits that exhibits diverse biological functions. Here, we show that 27-HMA activates the transcriptional activity of farnesoid X receptor (FXR), a nuclear receptor ...
Xiaoyan Gao +8 more
doaj +1 more source

Strength and Quality Assessment of Recycled Aggregate and Crumb Rubber Concrete Using the Ultra Pulse Velocity Method [PDF]

, 2020
This study focuses on the strength and quality of concrete incorporated with recycled aggregate and crumb rubber through the compressive strength test and the Ultra Pulse Velocity (UPV) test.
Abdullah, Siti Radziah +3 more
core

Behavior of a Novel Cyclic Olefin‐Based Hot‐Melt Adhesive in CFRP Adhesive Joints Compared to Conventional Epoxy‐Based Structural Adhesives

Polymer Composites, EarlyView.
Rate‐dependent performance of composite adhesive joints using thermoset and thermoplastic adhesives, in terms of toughness and fatigue behaviour. ABSTRACT A recently developed hot‐melt adhesive (HMA) based on cyclic olefin chemistry, supplied as a transparent, non‐tacky thermoplastic film with a distinctive polymer microstructure, was evaluated in this
Hossein Malekinejad +3 more
wiley +1 more source

Assessment of ecological fidelity of human microbiome-associated mice in observational studies and an interventional trial

mBio
Composition and function of the gut microbiome are associated with diverse health conditions and treatment responses. Human microbiota-associated (HMA) mouse models are used to establish causal links for these associations but have important limitations.
Matthew K. Wong +10 more
doaj +1 more source

The Mycobacterium tuberculosis Rv0132c Gene Product Mtb‐FGD2 Can Act as an F420‐Dependent Glucose Dehydrogenase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The role of the cell envelope‐associated Rv0132c/FGD2 from Mycobacterium tuberculosis has long been a subject of debate. Importantly, FGD2 is found only in pathogenic mycobacteria, making it a potential drug target. While some suggest it functions as a glucose‐6‐phosphate dehydrogenase, others propose it acts instead as an F420‐dependent ...
Adewale V. Aderemi +12 more
wiley +1 more source

Incremental Prognostic Value of Hippocampal Metabolic Activity for Sudden Cardiac Death in Patients With Heart Failure With Reduced Ejection Fraction

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Hippocampal injury is linked to cognitive impairment and cardiac events in patients with heart failure with reduced ejection fraction. However, the predictive value of hippocampal metabolic activity (HMA) for sudden cardiac death (SCD) and the
Zhiyong Shi +12 more
doaj +1 more source

Semi‐mechanistic population PK/PD model to aid clinical understanding of myelodysplastic syndromes following treatment with Venetoclax and Azacitidine

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 448-459, March 2025.
Abstract Myelodysplastic syndromes (MDS) represent a group of bone marrow disorders involving cytopenias, hypercellular bone marrow, and dysplastic hematopoietic progenitors. MDS remains a challenge to treat due to the complex interplay between disease‐induced and treatment‐related cytopenias.
Neha Thakre +5 more
wiley +1 more source

Big data in veterinary medicines regulation: A data landscape analysis to support regulatory activities

Veterinary Record, EarlyView.
Abstract Background This study describes the development of a data landscape analysis protocol that identifies and characterises animal health data sources to support key regulatory activities throughout the life cycle of veterinary medicines. Methods The protocol included: development of criteria to identify data sources; selection of variables to ...
Ewa Pacholewicz +4 more
wiley +1 more source

humans
venetoclax
3. good health

diseases of the blood and blood-forming organs
hypomethylating agents