Results 211 to 220 of about 54,581 (294)
Opening closed inward rectifier potassium channel doors
British Journal of Pharmacology, Volume 183, Issue 10, Page 2197-2218, May 2026.Inwardly rectifying potassium (KIR) channels are essential regulators of membrane potential in excitable and non‐excitable tissues. Although KIR channels exhibit a biophysical preference for potassium influx due to voltage‐dependent block of outward current by polyamines and Mg2+, under physiological conditions, they predominantly mediate K+ efflux ...Anna Stary‐Weinzinger, Fabian Kaiser, Marcel A. G. van der Heyden, Saïd Bendahhou +3 morewiley +1 more sourceCombining drugs that bypass p53 to treat TP53-mutated leukemias. [PDF]
Blood AdvBiswas S, Zahran ZAM, Gu X, Cardone L, Marti R, Mouannes N, Stich M, Jain A, Fedorov K, Tomlinson B, Goldfinger M, Verma A, Saunthararajah Y. +12 moreeuropepmc +1 more sourceSexual dysfunction is highly prevalent in patients with active perianal fistulizing Crohn's disease: Outcomes from a large national prospective cohort study
Colorectal Disease, Volume 28, Issue 5, May 2026.Abstract Background
Sexual function is one of the determinants of quality of life (QoL) and is prevalent in approximately half of the patients with inflammatory bowel disease. However, the sexual function in patients with perianal fistulizing Crohn's disease (pCD) needs to be further elucidated.Michiel T. J. Bak, Annemarie C. de Vries, Laurents P. S. Stassen, Moniek M. ter Kuile, Andrea E. van der Meulen – de Jong, Oddeke van Ruler, on behalf of the ALERT‐CD study group, the Dutch Initiative on Crohn and Colitis and the Dutch Initiative on Crohn and Colitis—Surgery, Michiel T.J. Bak, Laurents P.S. Stassen, Christianne J. Buskens, Aagje M. Pronk, Jarmila D.W. van der Bilt, Liesbeth J. Munster, Nanne K.H. de Boer, Krisztina B. Gecse, Robert‐Jan B. Pierik, Caroline D.M. Witjes, Claire E. Fitzpatrick, Stephanie O. Breukink, Marieke J. Pierik, Loes H.C. Nissen, Emiel G.G. Verdaasdonk, Lennard P.L. Gilissen, Johanne G. Bloemen, Wout G.N. Mares, Gabie M. de Jong, Marjolein Sikkema, David D.E. Zimmerman, Dominique Bierens‐Peters, Vincent de Jonge, Robert M. Smeenk, Bindia J. Jharap, Evelien de Witte, Mariëlle Romberg‐Camps, Alexander G.L. Bodelier, Ninos Ayez, Xander G. Vos, Margot A. van Herwaarden, Suzan Bos‐Poliste, Fleur A. Indemans, Petra G. A. van Boeckel, Michiel D. Voskuil, Egbert‐Jan van der Wouden, Annette D. van Dalsen, Saskia Willemsen‐Maas, Sigrid Vandebosch, Els van Dessel, Rob P.R. Adang, Joop L.M. Konsten, Sanne M. van Aalten, Margriet H. Wobbes, Esmerij P. van der Zanden, Sanne C. Veltkamp, Bareld B. Pultrum, Rinze W. F. ter Steege, Merel M. Tielemans, Mike van der Have, Abraham T. Zuur, Pieter C.J. ter Borg, Henri Braat, Tjeerd S. Aukema, Rogier J. L. Stuyt, Charles C. van Rossem, K. Evelyne Verweij, Justin Y. van Oostendorp, Ingrid Han‐Geurts, Patricia van Tongeren, Johannes A. Govaert, Sander van der Marel, Carmen S. Horjus, Jeroen M. Jansen, Sita V. Jansen, Alexander L.A. Bloemendaal, Rachel L. West, Robert T.J. Kortekaas, Koen C.M.J. Peeters, Andrea E. van der Meulen‐de Jong, Fiona D.M. van Schaik, Milan C. Richir, Koen W. van Dongen, Marjolijn Duijvestein, Dianne G. Bouwknegt, Froukje J. Hoogenboom, Marijn C. Visschedijk, Annemarie. C. de Vries, Oddeke van Ruler +86 morewiley +1 more sourceEquipped for success: genomes and metabolomes of the European Amanita muscaria are conserved in its novel South African range
New Phytologist, Volume 250, Issue 3, Page 1863-1883, May 2026.Summary Plants and soils have been moved around the world for centuries, but invasive mushrooms receive scant attention. The Amanita muscaria species complex was introduced to South Africa in the context of forestry, but its origins, ecology and recent evolution are unstudied. We sequenced the genomes of 24 Northern and Southern Hemisphere A. muscaria, Grant R. Nickles, Cecelia K. Stokes, Deborah L. Narh, Kira M. T. Lynn, Savannah R. Fuqua, Corbin Bryan, Brooke M. Allen, Christopher P. Bivins, Jin Woo Bok, J. Stephen Brewer, Sikelela T. Buthelezi, Jahiya P. R. M. Clark, Kerri L. Coon, Lauren R. Corby, Martin P. A. Coetzee, Claudette Dewing, Tuan A. Duong, Mathew A. Harris, Nancy P. Keller, Katlego Kopotsa, Frances A. Lane, Holly L. Nichols, Alandie Nieuwoudt, Martin A. Nuñez, Miguel E. Medina Munoz, Sung Chul Park, Nam Q. Pham, Kaetlyn T. Ryan, Myriam Solís, Rytas Vilgalys, Jasmine Marea Wallace, Yen‐Wen Wang, Brenda D. Wingfield, Michael J. Wingfield, Travis K. Worley, Taylor A. Zallek, Mostafa Zamanian, Jason D. Hoeksema, Milton T. Drott, Anne Pringle +39 morewiley +1 more sourceDecitabine-cedazuridine in patients with MDS and TP53 mutations. [PDF]
Blood AdvUrrutia S, Sasaki K, Bataller A, Kantarjian H, Montalban-Bravo G, McCloskey J, Griffiths EA, Yee K, Zeidan A, Savona M, Oganesian A, Sano Y, Keer HN, Garcia-Manero G. +13 moreeuropepmc +1 more source
