Results 11 to 20 of about 17,594 (264)

MiRNA10b-directed nanotherapy effectively targets brain metastases from breast cancer

open access: yesScientific Reports, 2021
RNA interference represents one of the most appealing therapeutic modalities for cancer because of its potency, versatility, and modularity. Because the mechanism is catalytic and affects the expression of disease-causing antigens at the post ...
Byunghee Yoo   +3 more
doaj   +1 more source

Global modeling of heterogeneous hydroxymethanesulfonate chemistry [PDF]

open access: yesAtmospheric Chemistry and Physics, 2021
Hydroxymethanesulfonate (HMS) has recently been identified as an abundant organosulfur compound in aerosols during winter haze episodes in northern China. It has also been detected in other regions although the concentrations are low.
S. Song   +14 more
doaj   +1 more source

Highly efficient conversion of glycerol and $t$-butanol to biofuel additives over AlPO solid acid catalyst under microwave irradiation technique: kinetic study

open access: yesComptes Rendus. Chimie, 2022
Metal-aluminophosphate solid acids ($m$-AlPO) were prepared and characterized by various techniques such as powder-XRD, FT-IR, BET surface area, SEM, TEM, EDAX, NH$_{3}$-TPD/$n$-butylamine back titration and ICP-OES techniques.
Shyam Prasad, K.   +1 more
doaj   +1 more source

Spatial distribution and ecological risk assessment of heavy metals in karst soils from the Yinjiang County, Southwest China [PDF]

open access: yesPeerJ, 2022
Background Soil heavy metals (HMs) under different land-use types have diverse effects, which may trigger the ecological risk. To explore the potential sources of HMs in karst soils, the spatial distribution and geochemical behavior of HMs based on ...
Ruiyin Han, Zhifang Xu
doaj   +2 more sources

A High-Throughput Small Molecule Screen Identifies Ouabain as Synergistic with miR-34a in Killing Lung Cancer Cells

open access: yesiScience, 2020
Summary: MicroRNA-34 (miR-34) is one of the major families of tumor suppressor miRNAs often lost in cancers. Delivery of miR-34a mimics to affected tumors as a therapeutic strategy has been tried in pre-clinical studies and in a phase I clinical trial ...
Rajesha Rupaimoole   +4 more
doaj   +1 more source

Progression of Metastasis through Lymphatic System

open access: yesCells, 2021
Lymph nodes are the most common sites of metastasis in cancer patients. Nodal disease status provides great prognostic power, but how lymph node metastases should be treated is under debate.
Hengbo Zhou   +2 more
doaj   +1 more source

Development and in vitro safety evaluation of pramipexole-loaded hollow mesoporous silica (HMS) particles

open access: yesBiotechnology & Biotechnological Equipment, 2019
In this study, spherical hollow mesoporous silica (HMS) particles with average size of 550 nm were loaded with dopamine-receptor agonist pramipexole, as a model drug. High drug loading (55%) was achieved by its incorporation in the reservoir structure of
Borislav Tzankov   +7 more
doaj   +1 more source

Targeting Histone Modifications in Breast Cancer: A Precise Weapon on the Way

open access: yesFrontiers in Cell and Developmental Biology, 2021
Histone modifications (HMs) contribute to maintaining genomic stability, transcription, DNA repair, and modulating chromatin in cancer cells. Furthermore, HMs are dynamic and reversible processes that involve interactions between numerous enzymes and ...
Wei Li   +6 more
doaj   +1 more source

Improving Access to HLA-Matched Kidney Transplants for African American Patients

open access: yesFrontiers in Immunology, 2022
IntroductionKidney transplants fail more often in Black than in non-Black (White, non-Black Hispanic, and Asian) recipients. We used the estimated physicochemical immunogenicity for polymorphic amino acids of donor/recipient HLAs to select weakly ...
Dulat Bekbolsynov   +8 more
doaj   +1 more source

Systematic analysis of BRAFV600E melanomas reveals a role for JNK/c‐Jun pathway in adaptive resistance to drug‐induced apoptosis

open access: yesMolecular Systems Biology, 2015
Drugs that inhibit RAF/MEK signaling, such as vemurafenib, elicit profound but often temporary anti‐tumor responses in patients with BRAFV600E melanoma.
Mohammad Fallahi‐Sichani   +5 more
doaj   +1 more source

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