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Matrine exerts an anti‐tumor effect via regulating HN1 in triple breast cancer both in vitro and in vivo

Chemical Biology and Drug Design, 2023
The treatment of triple‐negative breast cancer (TNBC) cannot meet medical needs, and it is urgent to find new drugs for intervention. This study aimed to investigate the anti‐tumor effect of matrine on the proliferation and apoptosis of TNBC cells based ...
Qiusheng Guo   +4 more
semanticscholar   +1 more source

The HN1/HMGB1 axis promotes the proliferation and metastasis of hepatocellular carcinoma and attenuates the chemosensitivity to oxaliplatin

The FEBS Journal, 2022
Hematological and neurological expressed 1 (HN1) is closely associated with the proliferation and metastasis of various tumors. However, the physiological functions and clinical significance of HN1 in hepatocellular carcinoma (HCC) remain indistinct.
Ruhua Wang   +8 more
semanticscholar   +1 more source

Hematological and neurological expressed 1 (HN1) activates c‐Myc signaling by inhibiting ubiquitin‐mediated proteasomal degradation of c‐Myc in hepatocellular carcinoma

Cell Biology International, 2022
Hepatocellular carcinoma (HCC) has a poor prognosis due to the usually advanced stage at diagnosis. Sustained activation of the MYC oncogene is implicated in the development of HCC; however, the molecular mechanisms of MYC deregulation in HCC are poorly ...
Jutao Feng   +5 more
semanticscholar   +1 more source

Curcumin suppresses colorectal cancer development with epithelial-mesenchymal transition via modulating circular RNA HN1/miR-302a-3p/PIK3R3 axis.

Journal of Physiology and Pharmacology, 2022
Curcumin has been testified to repress the development of multiple tumor cells. Nevertheless, the function of curcumin in colorectal cancer (CRC) is not completely clarified.
Z. Wu, X. Zhao, Y. Sun, H. Yu
semanticscholar   +1 more source

Proliferative Lesions Found at Reduction Mammaplasty: Incidence and Implications in 995 Breast Reductions

Plastic and Reconstructive Surgery, 2019
Background: Reduction mammaplasty relieves symptomatic macromastia. Pathologic specimens occasionally reveal unsuspected proliferative lesions or carcinoma. Few studies examine the incidence, risk factors, and outcomes in this population.
M. Mastroianni   +3 more
semanticscholar   +1 more source

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