Results 111 to 120 of about 123,814 (303)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Spartan Daily, October 13, 1989 [PDF]

open access: yes, 1989
Volume 93, Issue 30https://scholarworks.sjsu.edu/spartandaily/7890/thumbnail ...
San Jose State University, School of Journalism and Mass Communications
core   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

SOME ASPECTS OF BASES FOR OCCURRING PROPERTY RIGHTS FOR ANTIQUITIES

open access: yesRussian Journal of Economics and Law, 2012
The article analyzes the issue of occurring property right for antiquities, views the bases for occurring property right for antiquities. The author investigates and analyzes two bases for acquiring a property right for antiquities by discovering a hoard
R. T. Nurullina
doaj  

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The supposed Late Roman hoard of tools and a steelyard from Vodice near Kalce

open access: yesArheološki Vestnik, 2007
The War Museum in Logatec keeps a group of unprofes-sionally excavated, mostly Roman metal objects from the site of Vodice near Kalce. Among them there is also a supposed late Roman hoard of metal objects, the composition of which is not definitely known
Veronika Pflaum
doaj  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Early medieval hoard of forging and jewelry tools found at Voloave, Soroca District

open access: yesTyragetia, 2020
Depozitul de unelte meşteşugăreşti aparţinând unui făurar-giuvaiergiu, alcătuit din 19 obiecte din fier şi din bronz, a fost descoperit în împrejurimile localităţii Voloave, r-nul Soroca, în toamna anului 2018.
Ion Tentiuc, Valeriu Bubulici
doaj  

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

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