Results 111 to 120 of about 131,629 (255)

Semi‐mechanistic population PK/PD model to aid clinical understanding of myelodysplastic syndromes following treatment with Venetoclax and Azacitidine

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 448-459, March 2025.
Abstract Myelodysplastic syndromes (MDS) represent a group of bone marrow disorders involving cytopenias, hypercellular bone marrow, and dysplastic hematopoietic progenitors. MDS remains a challenge to treat due to the complex interplay between disease‐induced and treatment‐related cytopenias.
Neha Thakre, Corinna Maier, Jiuhong Zha, Benjamin Engelhardt, Johannes E. Wolff, Sven Mensing   +5 more
wiley   +1 more source

A Multiple‐Model‐Informed Drug‐Development Approach for Optimal Regimen Selection of an Oncolytic Virus in Combination With Pembrolizumab

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 572-582, March 2025.
ABSTRACT The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT‐bearing mice. In the CT26.WT‐bearing mouse model, the efficacy of the combination of hIL‐7/mIL‐12‐VV plus the anti‐programmed cell death protein (PD)‐1
Akihiro Yamada, Mary P. Choules, Frances A. Brightman, Shigeru Takeshita, Shinsuke Nakao, Nobuaki Amino, Takeshi Nakayama, Masato Takeuchi, Kanji Komatsu, Fernando Ortega, Hitesh Mistry, David Orrell, Christophe Chassagnole, Peter L. Bonate   +13 more
wiley   +1 more source

Push Forward Clinical Management of Hematological Toxicity due to Lenalidomide Overexposure: Model‐Informed Precision Dosing for Chinese Population With Renal Insufficiency

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Dose‐dependent hematological toxicity of lenalidomide has been reported previously, and thus, there is a clinical need for dose individualization to manage toxicities. The objectives of this study were to explore optimal individualized dosing regimens for Chinese B‐cell malignancies patients with varying degrees of renal function, and to push ...
Yi Ma, Zaiwei Song, Hao Bing, Huan He, Libo Zhao, Rongsheng Zhao   +5 more
wiley   +1 more source

Malignancies and immunoglobulin G4‐related disease

Rheumatology &Autoimmunity, EarlyView.
Immunoglobulin G4‐related disease (IgG4‐RD) is associated with increased cancer risk. Malignancies affect both IgG4‐RD involved organs, such as the lung, pancreas, bile duct, and prostate, and noninvolved organs, such as the gastrointestinal duct. B‐cell neoplasms constitute a proportion of the malignancies linked to this disease.
Jingna Li, Wen Zhang
wiley   +1 more source

Nanoparticle Therapeutics in Clinical Perspective: Classification, Marketed Products, and Regulatory Landscape

Small, EarlyView.
This review presents a detailed overview of clinically approved nanoparticle therapeutics, classifying them by type and discussing their unique advantages in drug delivery. It highlights regulatory challenges across global markets and emphasizes the need for adaptive approval pathways.
Nimeet Desai, Dhwani Rana, Mitali Patel, Neha Bajwa, Rajendra Prasad, Lalitkumar K. Vora   +5 more
wiley   +1 more source

CRISPR/Cas9‐edited tumor‐associated immune cells in cancer immunotherapy

VIEW, EarlyView.
Abstract Immuno‐oncology represents an emerging field that has significantly transformed tumor therapeutics, with immune cells serving as the cellular foundations of cancer immunotherapy. Due to its high efficiency and sensitivity, CRISPR/Cas9 genome editing is a highly promising technique for precise and rapid gene modification.
Yuhui Ma, Junxin Chen, Yuan Du, Zhihao Cao, Weizhi Ji, Yuyu Niu, Zebin Yang   +6 more
wiley   +1 more source

Long‐term survival in a dog with suspected primary nodal plasmacytoma treated with surgical excision

Veterinary Record Case Reports, EarlyView.
Abstract An 8‐year‐old Staffordshire bull terrier presented for left submandibular lymphadenopathy. Cytology showed a monomorphic population of mature plasma cells suggestive of plasma cell neoplasia. On physical examination, no other lymphadenomegaly, cutaneous or oral lesions were found.
Celia Figueroa‐González, Jérémy Béguin, Sarah Stewart, Rachel Garty, Alexandra Guillén   +4 more
wiley   +1 more source

Comparative global burden analysis of lymphoma subtypes: a statistical evaluation of severity across global regions. [PDF]

Front Public Health
Liang Y, Tang Y, WanYan Y, Li E.
europepmc   +1 more source

Pituitary adenoma management and outcomes according to hospital case volume and facility type

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
Abstract Objectives This study evaluates the influence of facility volume and type on the treatment and outcomes of pituitary adenoma (PA). Methods The 2004–2016 National Cancer Database was queried for patients with PA receiving definitive treatment. Tumor size represented the largest diameter of the primary tumor.
Khodayar Goshtasbi, Lauren Michelle, Sina J. Torabi, Kelsey Roman, Milind Vasudev, Arash Abiri, Ahmed Mohyeldin, Frank P. K. Hsu, Edward C. Kuan   +8 more
wiley   +1 more source

Primary Gastrointestinal EBV-Associated Classical Hodgkin Lymphoma in Crohn Disease on Anti-TNF-α Therapy: A Rare Association. [PDF]

JGH Open
Collins K, Toklu A, Dave N, Mesa H.
europepmc   +1 more source