Results 51 to 60 of about 589,865 (354)

An unusual case of late recurrent Hodgkin lymphoma presenting with soft tissue masses [PDF]

, 2015
Hodgkin lymphoma remains primarily a nodal disease. Extranodal involvement in Hodgkin lymphoma is less common than that seen in non-Hodgkin lymphoma. In particular, extranodal Hodgkin lymphoma involving soft tissues is extremely rare. We report a case of
Deng, Aileen, Javad, Asad, Kasner, Margaret, Uppal, Guldeep   +3 more
core  

Anti-programmed cell death protein-1/ligand-1 therapy in different cancers. [PDF]

, 2015
Immunologic checkpoint blockade with antibodies against the programmed cell death protein-1 (PD-1) or its ligand (PD-L1) is an effective method for reversing cancer immunosuppression and thereby promoting immune responses against several cancer types ...
Homet Moreno, B, Ribas, A
core   +2 more sources

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

JUNB, DUSP2, SGK1, SOCS1 and CREBBP are frequently mutated in T-cell/histiocyte-rich large B-cell lymphoma

Haematologica, 2019
T-cell/histiocyte-rich large B-cell lymphoma is a rare aggressive lymphoma showing histopathological overlap with nodular lymphocyte-predominant Hodgkin lymphoma.
Bianca Schuhmacher, Julia Bein, Tobias Rausch, Vladimir Benes, Thomas Tousseyn, Martine Vornanen, Maurilio Ponzoni, Lorenz Thurner, Randy Gascoyne, Christian Steidl, Ralf Küppers, Martin-Leo Hansmann, Sylvia Hartmann   +12 more
doaj   +1 more source

Subtype-specific and co-occurring genetic alterations in B-cell non-Hodgkin lymphoma

bioRxiv, 2019
B-cell non-Hodgkin’s lymphoma (B-NHL) encompasses multiple clinically and phenotypically distinct subtypes of malignancy with unique molecular etiologies.
Michael R. Green, Non-Hodgkin Lymphoma, Man Chun, John Man-shun Ma, Saber Tadros, Alyssa Bouska, Tayla B. Heavican, Haopeng Yang, Q. Deng, D. Moore, A. Akhter, K. Hartert, N. Jain, Jordan Showell, Sreejoyee Ghosh, L. Street, M. Davidson, Christopher D. Carey, J. Tobin, Deepak Perumal, J. Vose, M. Lunning, A. Sohani, Benjamin J Chen, S. Buckley, L. Nastoupil, R. Davis, J. Westin, N. Fowler, S. Parekh, M. Gandhi, S. Neelapu, D. Stewart, K. Bhalla, J. Iqbal, T. Greiner, S. Rodig, A. Mansoor   +37 more
semanticscholar   +1 more source

Polyclonal and monoclonal B lymphocytes response in HCV-infected patients treated with direct-acting antiviral agents [PDF]

, 2017
Hepatitis C virus (HCV) chronic infection can be associated with extrahepatic manifestations such as mixed cryoglobulinaemia and lymphoproliferative disorders that are endowed with increased rates of morbidity and all-cause mortality.
Burra, Patrizia, Farinati, Fabio, Floreani, Annarosa, Fogar, Paola, Franceschet, Enrica, Gambato, Martina, Nabergoj, Mitja, Pantano, G, Piva, Elisa, Plebani, Mario, Russo, FRANCESCO PAOLO, Schiavinato, Alvise, Tosato, Francesca, Zanetto, Alberto   +13 more
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Pulmonalis eltérések Hodgkin-lymphomában [PDF]

, 2016
Absztrakt A Hodgkin-lymphoma kezelése a hematológia sikertörténetei közé tartozik. A korszerű kombinált kemo- és radioterápiának köszönhetően a betegek jelentős része túlél, így előtérbe ...
Illés, Árpád, Jóna Ádám (1985-) (orvos), Jóna, Ádám, Miltényi, Zsófia, Szemes, Katalin   +4 more
core   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Lymphomas in Golestan province of Iran: Results of a population-based cancer registry [PDF]

, 2011
Introduction: Malignancies of lymphoid cells can be divided into Hodgkin and non-Hodgkin lymphomas (NHL) on the basis of pathologic features, clinical manifestations and treatment.
Aarabi, M., Besharat, S., Kalavi, K., Keshtkar, A., Moradi, A., Najafi, L., Noohi, A., Roshandel, G., Semnani, S.   +8 more
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