Results 101 to 110 of about 1,736,490 (289)
AN IMPROVED NEEDLE HOLDER. [PDF]
JAMA: The Journal of the American Medical Association, 1905 The needle holders now on the market are by no means perfect and, while I understand fully that my new device will be criticised, I feel that some members of the profession will appreciate its advantages and use it in preference to any previous instruments.
openaire +2 more sources
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
AN IMPROVED BURETTE HOLDER. [PDF]
Journal of the American Chemical Society, 1892 n ...
openaire +2 more sources
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Do Elections Always Motivate Incumbents?. [PDF]
This paper studies a principal-agent model of the relationship between office-holders and the electorate, where the office-holder is initially uninformed about herability (following Holmström, 1999).
le Borgne, E., Lockwood, B.
core
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
RECORD OF UNUSUAL NUMBER OF DWARF SHARK, Squaliolus laticaudus, OF THE SOUTH COAST OF BRAZIL
Boletim do Instituto de Pesca, 2018 Foram encontrados 47 tubarões-anões, Squaliolus laticaudus Smith e Radcliffe, 1912, em conteúdo estomacal de peixes pelágicos capturados através de espinhel de barcos atuneiros nacionais, no litoral sul do Brasil.
Victor SADOWSKI +2 more
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