Results 91 to 100 of about 1,736,490 (289)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Primeiro registro de tubarão-vaga-lume, Etmopterus gracilispinis KREFFT, 1968 (Squalidae), em águas brasileiras

open access: yesBoletim do Instituto de Pesca, 2018
Um exemplar de tubarão-vagalume, Etmopterus gracilispinis Krefft, 1968, foi capturado pelo espinhel de um atuneiro brasileiro no litoral do Estado do Rio Grande do Sul, Brasil  (33°S í  50°W).
Victor SANDOWKI   +2 more
doaj  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Development and On-Field Testing of Low-Cost Portable System for Monitoring PM2.5 Concentrations

open access: yesSensors, 2018
Recent developments in the field of low-cost sensors enable the design and implementation of compact, inexpensive and portable sensing units for air pollution monitoring with fine-detailed spatial and temporal resolution, in order to support applications
Konstantinos N. Genikomsakis   +5 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Penggunaan resin epoksi untuk pegangan alat-alat dapur

open access: yesMajalah Kulit, Karet, dan Plastik, 1999
Application of epoxy resin to make the kitchen tolls holder was investigated. Optimum compound of kitchen tools holder was reached for compound which it consist of epoxy resin : 100 parts, hardener 100 parts, carbon black 50 parts.
Dwi Wahini Nurhajati   +4 more
doaj   +1 more source

Understanding the Bare Breech Phenotype [PDF]

open access: yes, 2006
The document attached has been archived with permission from the publisher/copyright ...
Hebart, M., Hynd, P., Penno, N.
core   +1 more source

A NEW NEEDLE HOLDER. [PDF]

open access: yesJAMA: The Journal of the American Medical Association, 1895
The above drawing illustrates a needle holder which I have found more convenient than any other which I have heretofore used. The handle is of such size and shape that it can be firmly grasped by the hand. The two rings on the lower half of the handle are for the tips of the middle and third fingers, and the instrument is easily opened by grasping the ...
openaire   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

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