Results 21 to 30 of about 5,929 (263)

Deep Sequencing of FLT3‐ITD Enables Response Evaluation and Post‐Treatment Monitoring in Childhood AML: An Exploratory Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background An internal tandem duplication in the gene encoding Fms‐like tyrosine kinase 3 (FLT3‐ITD) is associated with high relapse risk and poor prognosis in acute myeloid leukemia (AML) and plays a crucial role in treatment decisions. Measurable residual disease (MRD) analysis of FLT3‐ITD during and after treatment has shown prognostic ...
Sofie Johansson Alm   +11 more
wiley   +1 more source

Claudin‐6 Protein Expression in Atypical Teratoid/Rhabdoid Tumors Is Strongly Enriched in the Molecular Subgroup AT/RT‐TYR

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke   +4 more
wiley   +1 more source

Holder continuity for vector-valued minimizers of quadratic functionals

open access: yesElectronic Journal of Differential Equations, 2020
In this article we give a sufficient condition for interior everywhere Holder continuity of weak minimizers of a class of quadratic functionals with coefficients $A_{ij}^{\alpha\beta}(\cdot,u)$ belonging to the VMO-class, uniformly with respect to $u\
Josef Danecek, Eugen Viszus
doaj  

Classical Solutions to the Initial-Boundary Value Problems for Nonautonomous Fractional Diffusion Equations

open access: yesComplexity, 2020
In this paper, we investigate a class of nonautonomous fractional diffusion equations (NFDEs). Firstly, under the condition of weighted Hölder continuity, the existence and two estimates of classical solutions are obtained by virtue of the properties of ...
Jia Mu, Yang Liu, Huanhuan Zhang
doaj   +1 more source

Holder Continuity of Quasiconformal Mappings of the Unit Ball [PDF]

open access: yesProceedings of the American Mathematical Society, 1988
The authors obtain a modified form of Gehring’s Hölder-continuity theorem for the family of K K -quasiconformal self ...
Anderson, G. D., Vamanamurthy, M. K.
openaire   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

An alternative approach to partial regularity of quasilinear elliptic systems with VMO coefficients

open access: yesJournal of Inequalities and Applications, 2016
In this paper, we provide an alternative approach to partially Hölder continuity of some quasilinear elliptic systems with discontinuous coefficients under natural growth.
Haiyan Yu, Shenzhou Zheng, Yuxia Tong
doaj   +1 more source

Gradient estimates for the fundamental solution of Lévy type operator

open access: yesAdvances in Nonlinear Analysis, 2020
We prove a gradient estimate and the Hölder continuity of the gradient for the fundamental solution of a class of α-stable type operators with α ∈ (0, 1), which improve known results in the literature where the condition α > 1/2 is commonly assumed.
Liu Wei, Song Renming, Xie Longjie
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

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