Results 121 to 130 of about 3,333,537 (255)

Dual‐Organelle Secretome Conjugation and Organ‐Uptake Tracking (DuO‐SCOUT) Enables Deep and Sensitive Mapping of the Secreted Proteins

Advanced Science, EarlyView.
A novel dual‐organelle proximity labeling platform, DuO‐SCOUT, decodes the complex landscape of systemic organ‐organ communication by capturing both classical and unconventional secretomes. Application in metabolic models maps the adipose‐to‐brain secretory relay, identifying selective extra‐hypothalamic sites for adipose‐derived factors and expanding ...
Fenglian Yang, Rui Qian, Jiaxing Song, Xingqi Meng, Jin Young Kim, Kwok On Lai, Li Wang, Liang Zhang   +7 more
wiley   +1 more source

Integrative oncology : international perspectives

, 2019
Interest in integrative oncology (IO) is growing globally. Patients with cancer are actively using traditional complementary and integrative medicine (TCIM) as part of their cancer and survivorship care.
Seely, Dugald, Balneaves, Lynda, Grant, Suzanne J. (R12231), Rossi, Elio, Bao, Ting, Hunter, Jennifer (R17944)   +5 more
core   +1 more source

A Multiscale Mechanistic Framework for Polydopamine Dyeing in Ultrablack Wool Textiles

Advanced Science, EarlyView.
Ultrablack photonic textiles are enabled through polydopamine (PDA) dyeing, which is governed by the interplay of PDA chemistry, wool surface topology and chemistry, and hierarchical fiber–yarn–fabric architecture. Fabric architecture emerges as a primary and previously underappreciated design lever for wide‐angle optical performance.
Hansadi Jayamaha, Kumar Siddharth, Kyuin Park, Mia Bressler, Larissa M. Shepherd   +4 more
wiley   +1 more source

An altmetric analysis of the research literature about traditional, complementary, and integrative medicine

Background: The use of traditional, complementary, and integrative medicine (TCIM) is known to be popular worldwide; there have been over 200,000 research articles published on this topic as of 2024.
Cramer, H, Ng, JY, Judge, A
core   +1 more source

A Huaxian Formula Nanoformulation Confers Protection Against Acute Radiation‐Induced Lung Injury by Targeting Ferroptosis

Advanced Science, EarlyView.
An inhalable, nanoengineered herbal therapy achieves protection against acute radiation‐induced lung injury via self‐assembled nanomicelle‐mediated pulmonary targeting and a previously unrecognized dual mechanism that attenuates oxidative stress while inhibiting ferroptosis in alveolar epithelial cells.
Li Quan, Junyang Chen, Xingmin Chen, Zengyi Fang, Yuanzhen Mi, Pingjin Zou, Shunlian Fu, Huakang Li, Ke Xu, Bing Lin, Jinyi Lang, Meihua Chen   +11 more
wiley   +1 more source

Interfacial Interaction‐Engineered Dual Lithiophilic Ultrathin Interlayers for Dendrite‐Suppressed Lithium Metal Textile Anodes

Advanced Science, EarlyView.
Ultrathin lithiophilic interlayers engineered on a 3D textile electrode and separator cooperatively regulate interfacial Li nucleation and Li+ transport, leading to homogeneous Li plating and mitigated dendrite formation. The resulting dual‐interfacial design provides long‐term cycling stability, improved full‐cell durability, and a scalable pathway ...
Chanseok Lee, Donghyeon Nam, Sang Hun Baeck, Boyeon Kim, Yongkwon Song, Jaemin Kim, Daegun Kim, Jun Hyuk Moon, Yoon Jang Chung, Hyeong Jun Kim, Seoin Back, Yongmin Ko, Jinhan Cho   +12 more
wiley   +1 more source

Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy

Advanced Science, EarlyView.
Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao, Markus Isfeld Diehl, Caroline N. Jones   +2 more
wiley   +1 more source

Targeting the CRYAB/β‐Catenin Axis with an MMP‐9‐Responsive Hydrogel Disrupts CTC Clusters to Suppress Progression of Hepatocellular Carcinoma after Radiofrequency Ablation

Advanced Science, EarlyView.
The graphical abstract illustrates that sublethal thermal stress after iRFA upregulates the chaperone CRYAB in residual HCC cells, which stabilizes β‐catenin and drives a dual pathological program, including EMT and N2‐TAN polarization, thereby leading to heterotypic CTC cluster formation. The MMP‐9‐responsive hydrogel (XB@Gel) delivers XAV‐939 and BMS‐
Hui Chen, Danni Yang, Songying Pi, Yuhan Liu, Hongbin Huang, Feile Ye, Yuhong Lin, Zhongzhen Su, Yongquan Huang   +8 more
wiley   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Enhanced data usability in dynamic 68 Ga-PSMA-11 PET of intracranial tumors using a dynamic head motion correction algorithm

EJNMMI Physics
Background Head motion during dynamic positron emission tomography (dPET) compromises pharmacokinetic modeling, especially in prolonged acquisitions where motion artifacts invalidate quantitative analysis.
Risheng Yang, Kun Guo, Guiyu Li, Ying Guo, Taoqi Ma, Fei Kang, Jing Wang   +6 more
doaj   +1 more source