Results 131 to 140 of about 59,107 (312)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Consistent response of European summers to the latitudinal temperature gradient over the Holocene. [PDF]

Nat Commun
Martin-Puertas C, Boyall L, Hernandez A, Ojala AEK, Abrook A, Kosonen E, Lincoln P, Portmann V, Swingedouw D.   +8 more
europepmc   +1 more source

Abrupt vegetation changes in the Segura Mountains of southern Spain throughout the Holocene [PDF]

, 2001
José S. Carrión, Manuel Munuera, Michèle Dupré, Antônia Costa Andrade   +3 more
openalex   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

El Niño modulated Holocene hydroclimate extremes as a dipolar pattern of droughts in northeastern China and floods in southwestern China. [PDF]

Sci Rep
Fan J, Xu H, Zhang F, Jiang H, Zhai D, Shi W, Wei X, Zhang W, Xiao J.   +8 more
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Holocene pollen and phytolith dataset from the Xinglong site in the Bashang Grassland, northern China. [PDF]

Data Brief
Wang G, Qiu Z, Zhuang L, Rao H, Yang Z, Liu W.   +5 more
europepmc   +1 more source

Mid- to late Holocene geomorphological and hydrological changes in the south Taihu area of the Yangtze delta plain, China

, 2018
Ting Chen, David B. Ryves, Zhanghua Wang, Jonathan P. Lewis, Yu Xuening   +4 more
openalex   +2 more sources

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Early Holocene Quantitative Summer Temperature Reconstructions in SE Lithuania Inferred from Chironomidae Data. [PDF]

Biology (Basel)
Gastevičienė N, Kluczynska G, Šeirienė V.   +2 more
europepmc   +1 more source