Results 141 to 150 of about 123,040 (288)

Persistent influence of the North Atlantic Oscillation on Late Holocene hydroclimate in southwestern Greenland. [PDF]

Nat Commun
Faust JC, Zhang Y, Born A, Hülse D, von Dobeneck T, Schulz H, Janßen A, Mukherjee S, Detlef H, Seidenkrantz MS, Jackson R, Titschack J, de Vernal A, Kucera M.   +13 more
europepmc   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Unearthing Forest History: Integrating Soil Charcoal Macrofossils and Pollen Reveals Delayed Forest Responses to Holocene Climatic Transitions in Boreal-Temperate Ecotone. [PDF]

Ecol Evol
Rioux-Couture C, Grondin P, de Lafontaine G.   +2 more
europepmc   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Holocene ocean-atmosphere coupling and Mediterranean sensitivity to Atlantic circulation: Lessons from the Late Bronze Age collapse. [PDF]

Sci Adv
Power K, Zhang Q.
europepmc   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Bony labyrinth morphology reveals deep population history and isolation among Homo sapiens in prehistoric northeastern Africa (44-3 ka). [PDF]

Nat Commun
Martin N, Velemínský P, Urciuoli A, Varadzinová L, Honegger M, Ambrose SH, Antoine D, Brandt SA, Brůžek J, Cauliez J, Duday H, Grine F, Brukner Havelková P, Irish JD, Jesse F, Maréchal L, Maureille B, Ribot I, Rmoutilova R, Rougier H, Santos F, Thibeault A, Usai D, Vanderesse N, Varadzin L, Whiting RJ, Crevecoeur I.   +26 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Postglacial ecosystem development of a hydrothermal landscape in Yellowstone National Park. [PDF]

Proc Natl Acad Sci U S A
Whitlock C, Schiller CM, Hostetler SW, Hurwitz S, Alt M, Brown SR, Harrison LN, Alder JR, Busch K, Shelly J, McWethy DB.   +10 more
europepmc   +1 more source