Results 131 to 140 of about 123,040 (288)

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Accretionary pedogenesis and Holocene climate evolution in black soil region of northeast China: Evidence from a sedimentary profile. [PDF]

PLoS One
Chen Y, Yang K, He F, Yu J, Yang Z, Qiao S, Wang J, Wang X, Liu J, Liu X, Wang C.   +10 more
europepmc   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Dental Microwear Evidence of Holocene Dietary Variability in the Argentinian Pampas and Paraná Delta. [PDF]

Am J Biol Anthropol
Carvalho MRG, Messineo PG, van Raap MAR, Flensborg G, Martínez G, Scheifler NA, Gonzalez ME, Álvarez MC, Kaufmann CA, Bonomo M, Scabuzzo C, Politis GG, El Zaatari S, Harvati K.   +13 more
europepmc   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

In the Holocene [PDF]

Critique d’art, 2014
openaire   +1 more source

Cenozoic losses of tree diversity constrain climatic adaptation of Western and Central European forests. [PDF]

Nat Commun
Wilkens V, Walentowitz A, Teichert S, Hülsmann L, Nürk N, Vetaas OR, Beierkuhnlein C.   +6 more
europepmc   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Diatom-based indications of an environmental regime shift and droughts associated with seasonal monsoons during the Holocene in Biển Hồ maar lake, the Central Highlands, Vietnam

The interactions of the different monsoon systems across Southeast Asia create extreme climate phenomena. Central Vietnam, located near the centre of this transitional region, has encountered numerous effects.
Unkel I., Nguyen Thuy, Duong, Nguyễn-Văn H., Fukumoto Y., Dinh Xuan, Thanh, Đào-Trung H., Nguyen Dinh, Thai   +6 more
core   +1 more source