Results 131 to 140 of about 89,718 (313)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Natural and anthropogenic forest fires recorded in the Holocene pollen record from a Jinchuan peat bog, northeastern China

, 2008
Pollen and charcoal particles from a Jinchuan peat (northeastern China) were examined to investigate the fire origin and interaction between climate, vegetation, fire and human activity during the Holocene.
Jiang, W, Liu, J, Wang, L, Ogle, N, Chu, G, Leroy, SAG   +5 more
core  

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Reconstruction of holocene lake-level changes in lake Xinias, central Greece

, 2007
A study of past lake-level changes in Lake Xinias covering the last 40 000 years was presented in an earlier paper. In that paper.. changes during the Holocene were only briefly dealt with. because of poor sedimentary representation.
Olsson, S, Digerfeldt, Gunnar,, Sandgren, Per,, Lund University.   +3 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Terrestrial climate variability and seasonality changes in the Mediterranean region between 15 000 and 4000 years BP deduced from marine pollen records

, 2009
Pollen-based climate reconstructions were performed on two high-resolution pollen marines cores from the Alboran and Aegean Seas in order to unravel the climatic variability in the coastal settings of the Mediterranean region between 15 000 and 4000 ...
Combourieu-Nebout, Nathalie, Magny, Michel, M. Magny, Peyron, Oliver, N. Combourieu Nebout, O. Peyron, Pross, Jörg, Goring, Simon, U. Kotthoff, Peyron, Odile, Kotthoff, Ulrich, Dormoy, Isabelle, I. Dormoy, Pross, Joerg, S. Goring, J. Pross   +15 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Palaeoceanography of the holocene and late-glacial N.E. Atlantic: development and application of biomarker proxies of environmental change [PDF]

, 2003
The aim of this thesis is to develop and apply novel climate proxies to understand the palaeoceanographic evolution of the N.E. Atlantic during the late-Glacial and Holocene.
Bendle, James Alexander Paul
core  

Holocene land degradation and climatic change in northeastern Iceland

, 2002
The spatial and temporal pattern of land degradation in northeastern Iceland during the Holocene is analysed in relation to climatic fluctuations. Tephrochronology is used to date the infer-red terrestrial changes.
Olafsdottir, Rannveig,, Lund University., Guomundsson, HJ   +2 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source