Results 131 to 140 of about 207,500 (310)

Southern Arabia Population Patterns and Intensity of Cultural Exchanges Across the Holocene Humid Period

Open Quaternary
The Early and Middle Holocene (10,000–3,000 BCE) in Southern Arabia witnessed significant climate change and variation in material culture across space and time.
Maria Pia Maiorano, Eugenio Bortolini
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Human Subsistence Before and After the 8.2 ka cal BP Event in Northern Iberia: Archaeozoology and Proteomic Data From the Macromammal Assemblage of El Mazo Rock Shelter

PaleoAnthropology
El Mazo rock shelter (Asturias, Spain) contains a long and well-dated Mesolithic sequence that shows an extended human presence between 9 and 7.4 ka cal BP, including the climatic 8.2 ka event.
Elene Arenas-Sorriqueta, Ana B. Marín-Arroyo, Igor Gutiérrez-Zugasti, David Cuenca-Solana, Fei Yang, Tamsin O'Connell   +5 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Corrigendum: 14,000-Year Carbon Accumulation Dynamics in a Siberian Lake Reveal Catchment and Lake Productivity

Frontiers in Earth Science, 2022
Lara Hughes-Allen, Lara Hughes-Allen, Frédéric Bouchard, Frédéric Bouchard, Christine Hatté, Hanno Meyer, Lyudmila A. Pestryakova, Bernhard Diekmann, Dmitry A. Subetto, Dmitry A. Subetto, Boris K. Biskaborn   +10 more
doaj   +1 more source

The new and reinstated genera of agglutinated foraminifera published between 1986 and 1996 [PDF]

, 2001
In the 10 years following the publication of "Foraminiferal Genera and their Classification" by Loeblich & Tappan (1987), some 91 new genera of agglutinated foraminifera have been proposed by various authors.
Kaminski, M.A.
core  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Mollusc-based paleoecological investigations of the Late Copper — Early Bronze Age earth mounds (kurgans) on the Great Hungarian Plain

Open Geosciences, 2013
Szilágyi Gábor, Sümegi Pál, Molnár Dávid, Sávai Szilvia   +3 more
doaj   +1 more source