Results 191 to 200 of about 240,870 (365)

Bone health: Age-related changes in diaphyseal structural properties among European Holocene humans during the last 9000 years. [PDF]

Sci Adv
Sládek V, Hora M, Wall-Scheffler C, Struška M, Berner M.   +4 more
europepmc   +1 more source

Holocene marine terraces and tectonic uplift in the Waimarama coastal plain, eastern North Island, New Zealand [PDF]

, 1989
Takahiro Miyauchi, Yôko Ôta, Alan G. Hull   +2 more
openalex   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Modern sea-level rise breaks 4,000-year stability in southeastern China. [PDF]

Nature
Lin Y, Kopp RE, Xiong H, Hibbert FD, Zheng Z, Yu F, Kumar P, Dangendorf S, Yi H, Zhang Y.   +9 more
europepmc   +1 more source

Coring of holocene pond sediments at Cape Herschel, Ellesmere Island, Arctic Archipelago

, 1978
Weston Blake
openalex   +1 more source

Major-element analyses of latest Pleistocene-Holocene lava fields of the Snake River Plain, Idaho [PDF]

, 1985
Mel A. Kuntz, H.N. Elsheimer, L.F. Espos, P.R. Klock   +3 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

North American "warming holes" and European heat during abrupt Holocene cooling events in the Atlantic. [PDF]

Nat Commun
Shuman BN, Stefanescu IC.
europepmc   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

New Perspectives on European Wildcat (<i>Felis silvestris</i>, Schreber 1777) Habitat Suitability in Britain: Integrating Fossil Records to Improve Baselines for Reintroduction. [PDF]

Ecol Evol
Mills M, Hemmingham L, Schreve D.
europepmc   +1 more source