Results 191 to 200 of about 59,107 (312)

Millennia of Metacommunity Diversification and Homogenization Captured by Sedimentary Ancient DNA. [PDF]

Ecol Lett
Rijal DP, Bråthen KA, Brown AG, Heintzman PD, Alsos IG, Yoccoz NG.   +5 more
europepmc   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Quaternary aminostratigraphies for the eastern North European Plain. [PDF]

Open Res Eur
Nelson E, White D, Wheeler L, Meng S, Szymanek M, Strahl J, Hein M, Alexandrowicz WP, Urban B, Greeves S, Stahlschmidt M, Kahlke RD, Lauer T, Tanner DC, Penkman KEH.   +14 more
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Bayesian analyses of radiocarbon dates suggest multiple origins of ceramic technology in Early Holocene Africa. [PDF]

Nat Commun
Rotunno R, Crema ER.
europepmc   +1 more source

Paleohydrology reconstruction and Holocene climate variability in the South Adriatic Sea

, 2012
Giuseppe Siani, Michel Magny, M. Paterne, Maxime Debret, Michel Fontugne   +4 more
openalex   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Major body size change in an extinct tropical island mammal associated with glacial-interglacial environmental shifts. [PDF]

iScience
Turvey ST, Lamb AL, Rye P, Vale Nieves A, Cooper JH, van Calsteren P.   +5 more
europepmc   +1 more source

Holocene

, 2016
openaire   +1 more source

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source