Results 201 to 210 of about 59,107 (312)

Seismic characterization of inland and coastal sabkhas using V_P, V_S, seismic anisotropy, and attenuation. [PDF]

Sci Rep
Eleslambouly A, Ali MY, Bouchaala F, El-Husseiny A, Al-Shuhail A, Hanafy SM, Matsushima J.   +6 more
europepmc   +1 more source

Human-environment relationships during the Late Glacial-Early Holocene transition: some examples from Campania, Calabria and Sicily

, 2009
Fabio Martini, André Carlo Colonese, Zelia Di Giuseppe, Massimiliano Ghinassi, Domenico Lo Vetro, Silvia Ricciardi   +5 more
openalex   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Diagnosing earth's tipping points: where we stand in the Anthropocene. [PDF]

Front Public Health
Rockström J.
europepmc   +1 more source

Recent Progress on Coral Reef Terrace Researches at Kikai Island, Southwestern Japan. Early Holocene Coral .DELTA.18O-based Sea Surface Temperature.

, 2000
Osamu Kiyama, Tsutomu Yamada, Toru Nakamori, Yasufumi Iryu   +3 more
openalex   +2 more sources

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

The Role of Summer Temperature on Aquatic Insect Diversity at Multi-Decadal Scales Within the Holocene. [PDF]

Glob Chang Biol
Abrook AM, Langdon PG, Inglis GN, Brauer A, Lincoln P, Mayfield R, Ojala AEK, Martin-Puertas C.   +7 more
europepmc   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Leveraging known Pacific colonisation times to test models for the ancestry of Southeast Asians. [PDF]

Sci Rep
Almeida M, Gandini F, Rito T, Foody MG, Brandão A, Oliveira M, Olivieri A, Fichera A, Oteo-Garcia G, Zainuddin Z, Eng KK, Pomat W, Bryk J, Pereira L, Farr H, Pala M, Oppenheimer SJ, Richards MB, Soares P.   +18 more
europepmc   +1 more source

Knowledge of Holocene hydro-climatic conditions in northern China from high temporal resolution stalagmites collected from Lianghua Cave

, 2018
Yi Wang, Dong Jinguo, Chuan‐Chou Shen, Xinggong Kong   +3 more
openalex