Results 231 to 240 of about 240,870 (365)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Monumental rock art illustrates that humans thrived in the Arabian Desert during the Pleistocene-Holocene transition. [PDF]

Nat Commun
Guagnin M, Shipton C, Al-Jibreen F, Losi G, Kalifi A, Armitage SJ, Stileman F, Stewart M, Al-Tamimi F, Breeze PS, van Buchem F, Drake N, Al-Shamry M, Al-Shammari A, Al-Wadani J, Alsharekh AM, Petraglia M.   +16 more
europepmc   +1 more source

Pleistocene(?) and Holocene fluvial history of Uphapee Creek, Macon County, Alabama [PDF]

, 1982
Helaine W. Markewich, Raymond A. Christopher   +1 more
openalex   +1 more source

Multi‐omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma

Molecular Oncology, EarlyView.
Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf, Daniel Ehinger, Hans Brunnström, Mats Jönsson, Frida Rosengren, Marija Kotevska, Anna Karlsson, Mattias Aine, Christian Frezza, Maria Planck, Elsa Arbajian   +10 more
wiley   +1 more source

Late Miocene to Holocene Planktonic Foraminifers from the Equatorial Atlantic, Leg 108

, 1989
P.P.E. Weaver, Maureen E. Raymo
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

How far are volcanologists from volcanoes? [PDF]

Bull Volcanol
Seropian G, Aubry TJ, Farquharson JI, Hickey J.   +3 more
europepmc   +1 more source

The Holocene evolution of Rheban Spit, Tasmania. 2. Soil development trends [PDF]

, 1987
GM Bowman
openalex   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Holocene climate change recorded of Milanggouwan and Dishaogouwan sedimentary profile in the Salawusu River Basin. [PDF]

Sci Rep
Sun Z, Zhang W, Liu L, Niu D, Li B, Gu S, Aketaqin G.   +6 more
europepmc   +1 more source