Results 201 to 210 of about 2,375 (233)

Homocysteine and holotranscobalamin and the risk of Alzheimer disease [PDF]

Neurology, 2010
To examine the relation between serum levels of homocysteine (tHcy) and holotranscobalamin (holoTC), the active fraction of vitamin B12, and risk of incident Alzheimer disease (AD) in a sample of Finnish community-dwelling elderly.A dementia-free sample of 271 subjects aged 65-79 years derived from the Cardiovascular Risk Factors, Aging, and Dementia ...
B. Hooshmand, A. Solomon, I. Kareholt, J. Leiviska, M. Rusanen, S. Ahtiluoto, B. Winblad, T. Laatikainen, H. Soininen, M. Kivipelto   +9 more
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Full title: Reference Intervals and Stability of Haptocorrin and Holotranscobalamin in Danish Children and Elderly.

Clinica Chimica Acta, 2023
Haptocorrin (HC) and holotranscobalamin (holoTC) carry vitamin B12 (B12) in the circulation and can be useful biomarkers for evaluating B12 status. The concentration of both proteins depends on age, but data on reference intervals for children and the elderly are sparse.
C. S. Knudsen, T. Parkner, Elke Hoffmann-Lücke, A. Abildgaard, Eva Greibe   +4 more
semanticscholar   +3 more sources

Biological variation of holotranscobalamin and cobalamin in healthy individuals

Scandinavian Journal of Clinical and Laboratory Investigation, 2017
Data on biological variation for cobalamin and holotranscobalamin (holoTC) are limited. The aim of this study was to determine within-subject (CVI) and between-subject (CVG) biological variations for these analytes in a healthy population. We collected blood samples from 15 healthy volunteers (12 women and three men, 22-66 years) on the same weekday ...
M. Brokner, H. Hager, M. Lindberg
semanticscholar   +3 more sources

Holotranscobalamin Levels in Children with Helicobacter Pylori Infection

Helicobacter, 2016
AbstractBackgroundThe purpose of this study was to evaluate the association between vitamin B12 levels and Helicobacter Pylori infection and to examine the clinical usefulness of holotranscobalamin (holoTC) measurement in children.Materials and MethodsThirty patients between 6 and 15 years of age, who were diagnosed as H.
Oğuz Afyoncu, Orhan Gursel, A. Atay, E. Kurekci, N. Balamtekin, A. Haşimi, Mehmet A. Ozguven, O. Ozcan   +7 more
semanticscholar   +3 more sources

Continuous reference intervals for holotranscobalamin, homocysteine and folate in a healthy paediatric cohort

Annals of Clinical Biochemistry: International Journal of Laboratory Medicine
Background The detection of deficiencies in B12 and folate children is important. However, despite the availability of various markers to assess B12 and folate metabolism, there are limited studies describing the reference intervals (RIs) and changes ...
Joel D Smith, V. Karlaftis, Stephen Hearps, C. Attard, Helen Savoia, Janine Campbell, Paul Monagle   +6 more
semanticscholar   +3 more sources

Holotranscobalamin — a sensitive marker of cobalamin malabsorption

European Journal of Clinical Investigation, 1999
BackgroundNo simple and reliable method of identifying patients with cobalamin malabsorption is available at present. The measurement of plasma holotranscobalamin, i.e. the metabolically active cobalamins bound to the transport protein transcobalamin, has been suggested as a means of fulfilling such criteria.DesignWe describe a method that directly ...
A, Lindgren, A, Kilander, E, Bagge, E, Nexø   +3 more
openaire   +2 more sources

Chemotherapy-induced suppression of serum holotranscobalamin

Journal of Clinical Oncology, 2009
e20639 Purpose: Chemotherapy-induced damage to the stomach and small intestine may inhibit the absorption of vitamin B12. To assess the risk of chemotherapy causing acute vitamin B12 deficiency, we primarily measured the active form of vitamin B12, holotranscobalamin, but also total serum B12, methylmalonic acid, and total homocysteine.
G. Tisman, S. J. Kutik, Y. A. Khan
openaire   +1 more source

Holotranscobalamin as a Predictor of Vitamin B12 Status

Clinical Chemistry and Laboratory Medicine, 2003
We report on the performance of a new test, holotranscobalamin, as compared to well established markers of vitamin B12 deficiency (plasma cobalamins, methylmalonic acid, and homocysteine). Holotranscobalamin was analyzed in 143 samples by a competitive radiobinding assay (Axis-Shield). Employing a cut-off value of 50 pmol/l, holotranscobalamin showed a
Hvas, A.-M., Nexø, E.
openaire   +3 more sources

Diagnostic performance of a holotranscobalamin reflex testing algorithm – A clinical audit

Pathology, 2018
Phoebe Stanford, Forough Bahadory, A. Horvath   +2 more
semanticscholar   +2 more sources