Results 211 to 220 of about 2,375 (233)

Performance Characteristics of the ARCHITECT Active-B12 (Holotranscobalamin) Assay

Clinical Laboratory, 2015
Vitamin B12 (cobalamin) is a necessary cofactor in methionine and succinyl-CoA metabolism. Studies estimate the deficiency prevalence as high as 30% in the elderly population. Ten to thirty percent of circulating cobalamin is bound to transcobalamin (holotranscobalamin, holoTC) which can readily enter cells and is therefore considered the bioactive ...
Stephen D, Merrigan, William E, Owen, Joely A, Straseski   +2 more
openaire   +2 more sources

A-356 Development of postpartum-specific reference intervals for serum vitamin B12 and holotranscobalamin for reliable assessment of vitamin B12 status

Clinical Chemistry
Maternal vitamin B12 levels fluctuate during pregnancy and postpartum due to dynamic changes in holotranscobalamin and holohaptocorrin driven by physiochemical shifts.
Soundravally Rajendiran, Devanatha Desikan, Pooja Dhiman, P. Veena, Balaji Bharadwaj, N. Premkumar   +5 more
semanticscholar   +1 more source

Holotranscobalamins in B12 and non B12 requiring prokaryotes and eukaryotes

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 1996
Transcobalamins, vitamin B12 binding proteins, deliver B12 to cell surface receptors which then permit B12 to cross cell membranes for metabolic use. There is little documentation concerning B12 binding proteins in bacteria and protists. We found that prokaryotes and eukaryotes requiring B12, as well as those protists synthesizing B12, also produce ...
H, Baker, B, de Angelis, M, Khalil, O, Frank, E R, Baker   +4 more
openaire   +2 more sources

Reference intervals for serum total vitamin B12 and holotranscobalamin concentrations and their change points with methylmalonic acid concentration to assess vitamin B12 status during early and mid-pregnancy

Clinical Chemistry and Laboratory Medicine, 2019
Background Maternal vitamin B12 (B-12) adequacy is important for maternal health and optimal fetal growth. However, pregnancy-specific cut-offs for B-12 biomarkers are lacking. Methods Reference intervals for serum total B-12, holotranscobalamin (holoTC)
Theresa H. Schroder, A. Tan, A. Mattman, G. Sinclair, S. Barr, H. Vallance, Y. Lamers   +6 more
semanticscholar   +1 more source

CLINICAL USEFULNESS OF HOLOTRANSCOBALAMIN MEASUREMENT

Clinical chemistry and laboratory medicine, 2008
The aim of this study was to assess clinical usefulness of holotranscobalamin measurement.
Mandić, Sanja, Horvat, Vesna, Mandić, Dario, Majetić-Cetina, Neda   +3 more
openaire   +2 more sources

Functional Vitamin B12 Deficiency and Determination of Holotranscobalamin in Populations at Risk

Clinical Chemistry and Laboratory Medicine, 2003
The prevalence of a sub-clinical functional vitamin B12 deficiency in the general population is higher than previously expected. Total serum vitamin B12 may not reliably indicate vitamin B12 status. To get more specificity and sensitivity in diagnosing vitamin B12 deficiency, the concept of measuring holotranscobalamin II (holoTC), a sub-fraction of ...
Wolfgang, Herrmann, Rima, Obeid, Heike, Schorr, Jürgen, Geisel   +3 more
openaire   +2 more sources

Frequency of Combined Deficiencies of Vitamin D and Holotranscobalamin in Cancer Patients

Nutrition and Cancer, 2004
Abstract Low serum levels of vitamin D are associated with a higher frequency of at least eleven different malignancies including breast, colon, and prostate cancer (Holick, M.F. Vitamin D: Millenium Perspective. Journal of Cellular Biochemistry. 2003. 88:296–307).
Ashley Serene, Plant, Glenn, Tisman
openaire   +2 more sources

COBALAMIN AND HOLOTRANSCOBALAMIN IN HUMAN SEMINAL FLUID

Clinical chemistry and laboratory medicine, 2009
Background: Some recent study supports the role of cobalamin in spermatogenesis and correlation with several sperm parameters. Cobalamin (vitamin B12) is bound to two proteins, transcobalamin and haptocorrin. Holotranscobalamin (also known as active B12 or holo-TC) is a metabolically active form of cobalamin, and this parameter showed promising results
Mandić, Sanja, Majetić-Cetina, Neda, Debeljak, Željko, Horvat, Vesna, Mandić, Dario   +4 more
openaire   +1 more source

Associations between holotranscobalamin, vitamin B12, homocysteine and depressive symptoms in community‐dwelling elders

International Journal of Geriatric Psychiatry, 2011
AbstractBackgroundVitamin B12 and homocysteine have been shown to be associated with depression or depressive symptoms, but the relationship has not been universal. Both vitamin B12 and homocysteine may exert an effect via vascular mechanisms; it is possible that other mechanisms apply.
D J, Robinson, C, O'Luanaigh, E, Tehee, H, O'Connell, F, Hamilton, A V, Chin, R, Coen, A M, Molloy, J, Scott, C J, Cunningham, B A, Lawlor   +10 more
openaire   +2 more sources

The relationship of leukocyte anisocytosis to holotranscobalamin, a marker of cobalamin deficiency

International Journal of Laboratory Hematology, 2011
SummaryIntroduction:  After measurement of the mean volumes of leukocyte subpopulations as well as the distribution widths (DW) of these volumes has become available, we investigated whether such morphometric leukocyte parameters are associated with a commonly used marker of cobalamin deficiency, i.e., holotranscobalamin (HoloTC).
C, Risch, P, Medina, U E, Nydegger, Z, Bahador, T, Brinkmann, P, Von Landenberg, M, Risch, L, Risch   +7 more
openaire   +2 more sources