Results 71 to 80 of about 33,603 (213)

Targeted Anti‐IL‐1 Immunomodulatory Therapy in Pediatric Onset PPP1R13L‐Related Arrhythmogenic Cardiomyopathy

American Journal of Medical Genetics Part A, Volume 200, Issue 8, Page 1807-1813, August 2026.
ABSTRACT Autosomal recessive loss‐of‐function variants in PPP1R13L cause an ultra‐rare cardiocutaneous syndrome characterized by rapidly progressive arrhythmogenic cardiomyopathy (ACM). PPP1R13L encodes iASPP, which has two potentially overlapping mechanisms driving ACM as both a regulator of NFκB‐mediated inflammation and a binding partner within the ...
Aaron Renberg, Savannah Coppersmith, Owen Merritt, Amer Heider, Adam Helms, Thomas Michniacki, Jack Luxford, Sarah Josephi‐Taylor, Philip Roberts, Joshua Meisner   +9 more
wiley   +1 more source

A Comprehensive and Critical Evaluation of Autonomic Nervous System Impairment in Patients with Wilson Disease: A Cross‐Sectional Study

Brain and Behavior, Volume 16, Issue 8, August 2026.
ABSTRACT Background Wilson's disease (WD) is an autosomal recessive disorder of copper metabolism with heterogeneous hepatic and neurological manifestations. Autonomic nervous system (ANS) involvement in WD is poorly recognized and remains inadequately studied, despite its potential to cause significant morbidity if unrecognized.
Sabyasachi Pattanayak, Niraj Kumar Srivastava, Anand Kumar, Deepika Joshi, Atanu Roy, Sanjeev Kumar Singh, Rajniti Prasad, Suyash Tripathi, Ashish Verma, Ritu Ojha, Varun Kumar Singh, Abhishek Pathak, Rameshwar Nath Chaurasia, Vijaya Nath Mishra, Ibrahim Hussain   +14 more
wiley   +1 more source

A Concealed Typical AVNRT: U Wave Contribution in Simulating Long RP Supraventricular Tachycardia

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Accurate identification of P waves on electrocardiogram (ECG) is essential in supraventricular tachycardias because U waves may resemble retrograde P waves, producing a pseudo–long RP interval and hiding typical atrioventricular nodal reentrant tachycardia (AVNRT).
Gabriela‐Elena Marascu, Alexandru Deaconu, Viviana Alexandra Gondos, Radu‐Gabriel Vatasescu   +3 more
wiley   +1 more source

Evidence‐Based Nursing Management During Mavacamten Therapy in an 89‐Year‐Old Patient With Symptomatic Hypertrophic Obstructive Cardiomyopathy: A Case Report

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT In older patients receiving mavacamten, a reduction in NT‐proBNP levels may coexist with persistent severe LVOTO. Nurses should interpret this biomarker–echocardiography discordance as a safety signal and maintain structured cardiovascular surveillance rather than assuming treatment success based solely on biomarker improvement.
Feifei Wang
wiley   +1 more source

Atypical Autonomic‐Predominant Guillain‐Barré Syndrome With Pandysautonomia Mimicking Parkinsonism and Recurrent Syncope: A Case Report

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Guillain‐Barré syndrome with pandysautonomia can mimic neurodegenerative and cardiogenic conditions, particularly in elderly patients presenting with autonomic symptoms and parkinsonian features. Timely neurologic evaluation and ganglioside antibody testing—especially anti‐GM2—are essential for accurate diagnosis and the initiation of ...
Rua Alsaeed, Nabel Rajab Basha, Sangharsha Thapa, Jin Li   +3 more
wiley   +1 more source

What shall we do with the Canaanites? An Ethical Perspective on Genesis 12:6

Old Testament Essays, 2017
Colonial biblical interpretation—such as for example Moritz Merker’s study of the Maasai (1904/1910), where he claims that they are historically related to the ancient Israelites—tend to see both “Israelites” and their counterparts, the “Canaanites,” in ...
Knut Holter
doaj  

Safety, Tolerability, Pharmacokinetics, Food Effect of Ribitol, and Its Effect on QTcF in Healthy Adults: First‐in‐Human, Randomized, Double‐Blind (Sponsor Unblinded), Placebo‐Controlled Studies

Clinical Pharmacology in Drug Development, Volume 15, Issue 8, August 2026.
Abstract Limb‐girdle muscle dystrophy Type R9 (LGMDR9), also known as LGMD Type 2I, is a rare genetic disease caused by partial loss of function of fukutin‐related protein (FKRP) enzyme which glycosylates alpha‐dystroglycan, thereby stabilizing myocytes during contraction.
Daniel D. Gretler, Athiwat Hutchaleelaha, Uma Sinha, Kristen Rickert, Doug Sproule   +4 more
wiley   +1 more source

Safety, Pharmacokinetics, Food effect, and Pharmacodynamics of AJM347, a Selective α4β7 Integrin Antagonist: A First‐in‐Human Single‐ and Multiple‐Ascending Dose Study in Healthy Male Volunteers

The Journal of Clinical Pharmacology, Volume 66, Issue 8, August 2026.
Abstract This first‐in‐human study evaluated the safety, pharmacokinetics (PK), food effect, and pharmacodynamics (PD) of AJM347, a novel orally active, selective α4β7 integrin antagonist, in healthy Caucasian and Japanese adult males. The study consisted of three parts.
Tetsuya Koyama, Tatsunori Seki
wiley   +1 more source

Methodological Considerations on Pre‐Sport Cardiac Evaluation in Children: Detection of Risks Other Than Sudden Cardiac Death

Annals of Noninvasive Electrocardiology, Volume 31, Issue 5, September 2026.
Abdullah Aman, Ahmed Raza, Shahzadi Gulfishan   +2 more
wiley   +1 more source

Documented Obstructive Sleep Apnea, Cardiometabolic Phenotype, and Rhythm‐Related Outcomes After Atrial Fibrillation Ablation: An Observational Cohort Study

Journal of Arrhythmia, Volume 42, Issue 4, August 2026.
Documented OSAS identified a higher‐risk cardiometabolic phenotype in patients undergoing AF ablation, including greater obesity, hypertension, diabetes, persistent AF, and adverse lipid markers. However, it did not independently predict post‐ablation rhythm‐related outcomes in either the registry cohort or the actively followed cohort.
Yazan Mohsen, Iryna Novikov, Shreeram Sabareesan, Kensuke Sakata, Moritz Knitter, Henning Horlitz, Lucas Steffens, Marc Horlitz, Ibrahim Antoun, Florian Stöckigt   +9 more
wiley   +1 more source